Are Simple Magnetic Resonance Imaging Biomarkers Predictive of Neurodevelopmental Outcome at Two Years in Very Preterm Infants?

Neonatology ◽  
2019 ◽  
Vol 116 (4) ◽  
pp. 331-340 ◽  
Author(s):  
Monia Vanessa Dewan ◽  
Ralf Herrmann ◽  
Bernd Schweiger ◽  
Selma Sirin ◽  
Hanna Müller ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals Routine Magnetic Resonance Imaging at Term-Equivalent Age Detects Brain Injury in 25% of a Contemporary Cohort of Very Preterm Infants

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169442 ◽  
Author(s):  
Vera Neubauer ◽  
Tanja Djurdjevic ◽  
Elke Griesmaier ◽  
Marlene Biermayr ◽  
Elke Ruth Gizewski ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Injury ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Resonance Imaging ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Routine Magnetic Resonance Imaging

Magnetic Resonance Imaging of the Brain in Very Preterm Infants: Visualization of the Germinal Matrix, Early Myelination, and Cortical Folding

PEDIATRICS ◽  
1998 ◽  
Vol 101 (6) ◽  
pp. 957-962 ◽  
Author(s):  
M. R. Battin ◽  
E. F. Maalouf ◽  
S. J. Counsell ◽  
A. H. Herlihy ◽  
M. A. Rutherford ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Cortical Folding ◽  
Resonance Imaging ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
The Brain

scholarly journals Multiparametric Analysis of Cerebral Development in Preterm Infants Using Magnetic Resonance Imaging

2021 ◽  
Vol 15 ◽  
Author(s):  
Marine Dubois ◽  
Antoine Legouhy ◽  
Isabelle Corouge ◽  
Olivier Commowick ◽  
Baptiste Morel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Gestational Age ◽  
Brain Maturation ◽  
Resonance Imaging ◽  
Equivalent Age ◽  
Very Preterm ◽  
Extremely Preterm ◽  
The Impact

ObjectivesThe severity of neurocognitive impairment increases with prematurity. However, its mechanisms remain poorly understood. Our aim was firstly to identify multiparametric magnetic resonance imaging (MRI) markers that differ according to the degree of prematurity, and secondly to evaluate the impact of clinical complications on these markers.Materials and MethodsWe prospectively enrolled preterm infants who were divided into two groups according to their degree of prematurity: extremely preterm (<28 weeks’ gestational age) and very preterm (28–32 weeks’ gestational age). They underwent a multiparametric brain MRI scan at term-equivalent age including morphological, diffusion tensor and arterial spin labeling (ASL) perfusion sequences. We quantified overall and regional volumes, diffusion parameters, and cerebral blood flow (CBF). We then compared the parameters for the two groups. We also assessed the effects of clinical data and potential MRI morphological abnormalities on those parameters.ResultsThirty-four preterm infants were included. Extremely preterm infants (n = 13) had significantly higher frontal relative volumes (p = 0.04), frontal GM relative volumes (p = 0.03), and regional CBF than very preterm infants, but they had lower brainstem and insular relative volumes (respectively p = 0.008 and 0.04). Preterm infants with WM lesions on MRI had significantly lower overall GM CBF (13.3 ± 2 ml/100 g/min versus 17.7 ± 2.5, < ml/100 g/min p = 0.03).ConclusionMagnetic resonance imaging brain scans performed at term-equivalent age in preterm infants provide quantitative imaging parameters that differ with respect to the degree of prematurity, related to brain maturation.

Head Growth in Preterm Infants: Correlation With Magnetic Resonance Imaging and Neurodevelopmental Outcome

PEDIATRICS ◽  
2008 ◽  
Vol 121 (6) ◽  
pp. e1534-e1540 ◽  
Author(s):  
J. L. Y. Cheong ◽  
R. W. Hunt ◽  
P. J. Anderson ◽  
K. Howard ◽  
D. K. Thompson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Resonance Imaging ◽  
Head Growth

Value of Cranial Ultrasound and Magnetic Resonance Imaging in Predicting Neurodevelopmental Outcome in Preterm Infants

PEDIATRICS ◽  
1992 ◽  
Vol 90 (2) ◽  
pp. 196-199
Author(s):  
Margot van de Bor ◽  
Lya den Ouden ◽  
Gerard L. Guit
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Predictive Factor ◽  
Intraventricular Hemorrhage ◽  
Periventricular Leukomalacia ◽  
Neurodevelopmental Outcome ◽  
Cranial Ultrasound ◽  
Resonance Imaging ◽  
Postmenstrual Age

In this prospective study, cranial ultrasound was performed to detect periventricular-intraventricular hemorrhage and periventricular leukomalacia in 33 preterm infants of less than 32 weeks' gestation. At 44 weeks postmenstrual age magnetic resonance imaging was performed to detect the stage of myelination. Neurodevelopmental outcome was assessed at 3 years of age in 31 children (2 children died in the first year of life). Significant correlations were found between neurodevelopmental outcome and ultrasound findings (χ2 = 32.8; P < .0001) and stage of myelination (χ2 = 20.5; P < .0005). To establish the criterion with the best predictive factor, multiple regression analysis was performed with outcome as dependent variable and periventricular-intraventricular hemorrhage, periventricular leukomalacia, and stage of myelination as independent variables. It appeared that the detection of periventricular leukomalacia with ultrasound showed the best predictive factor for neurodevelopmental outcome. Routine magnetic resonance imaging at 44 weeks postmenstrual age should not be performed just for the purpose of predicting neurodevelopmental outcome more reliably.

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