scholarly journals Hyaluronic Acid as an Alternative to Autologous Human Serum Eye Drops: Initial Clinical Results with High-Molecular-Weight Hyaluronic Acid Eye Drops

2019 ◽  
Vol 10 (2) ◽  
pp. 244-255 ◽  
Author(s):  
Ria Beck ◽  
Oliver Stachs ◽  
Anita Koschmieder ◽  
Wolfgang G.K. Mueller-Lierheim ◽  
Sabine Peschel ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
High Molecular Weight ◽  
Dry Eye ◽  
Autologous Serum ◽  
Control Group ◽  
Eye Drops ◽  
Very High ◽  
Serum Eye Drops ◽  
Better Than

Introduction: Autologous serum eye drops (ASED) are used in the treatment of most severe stages of dry eye. Once introduced, it is currently considered impossible to return to other lubricating eye drops or other commercially available therapeutic regimen. Materials and Methods: In a randomized study, non-preserved high-molecular-weight hyaluronic acid eye drops were offered as an alternative to 11 patients using autologous serum treatment for at least 3 months. The control group (n = 5) continued their treatment with ASED. The verum group (n = 6) used very-high-molecular-weight hyaluronic eye drops (Comfort Shield®) instead of the ASED. Results: From four of initially six patients in the verum group that finished the study, 2 (50%) preferred to stay with the very-high-molecular-weight hyaluronic acid eye drops beyond the trial period, the other two returned to the earlier therapy with ASED. The control group continued their treatment as before and finished the study after 8 weeks. Conclusion: For the first time, artificial eye drops, i.e., high-molecular-weight hyaluronic acid eye drops, offered an acceptable alternative to ASED. Some patients perceived these drops as even better than the patient’s own serum. This is the first evidence that optimization of the molecular structure of hyaluronic acid can be used to create eye drops that are perceived to be better than other tested tear substitutes and even patients’ own serum. This offers a new treatment perspective for patients with very severe dry eye disease.

scholarly journals The Effects of High Molecular Weight Hyaluronic Acid Eye Drop Application in Environmental Dry Eye Stress Model Mice

2020 ◽  
Vol 21 (10) ◽  
pp. 3516 ◽  
Author(s):  
Takashi Kojima ◽  
Taeko Nagata ◽  
Haruka Kudo ◽  
Wolfgang G. K. Müller-Lierheim ◽  
Gysbert-Botho van Setten ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
High Molecular Weight ◽  
Dry Eye ◽  
Ophthalmic Solution ◽  
Low Molecular Weight ◽  
Eye Drops ◽  
Office Work ◽  
Lissamine Green ◽  
Inflammatory Effect

Hyaluronic acid (HA) ophthalmic solution is widely used in dry eye treatment worldwide. However, there are no reports comparing the dry eye treatment effects of high molecular weight HA with low molecular weight HA. Sixty eight-week-old C57BL/6 mice were assigned to the following 6 groups and exposed to environmental dry eye stress (EDES) that mimics office work environment: (1) 0.1% low molecular weight HA (LMWHA) eye drops, (2) 0.3% LMWHA eye drops, (3) 3% diquafosol sodium (DQ) eye drops, (4) 0.15% high molecular weight HA (HMWHA) eye drops, (5) no treatment with exposure to EDES (EDES+/Treatment−), and (6) no treatment without exposure to EDES (EDES−/Treatment−). After EDES, the HMWHA group had significantly longer break-up time (BUT) than the 0.1%, 0.3% LMWHA groups and the DQ group. After EDES, the HMWHA group had significantly lower lissamine green staining scores than the LMWHA and DQ groups. Subepithelial presumed dendritic cell density in the HMWHA group was significantly lower than the EDES+/Treatment− group. After EDES exposure, Conjunctival Muc5AC mRNA expression in the HMWHA group was significantly higher than the 0.1 and 0.3% LMWHA groups. Ophthalmic HMWHA solution may have a better dry eye treatment effect than LMWHA or DQ solution, owing to its anti-inflammatory effect.

scholarly journals The HYLAN M Study: Efficacy of 0.15% High Molecular Weight Hyaluronan Fluid in the Treatment of Severe Dry Eye Disease in a Multicenter Randomized Trial

2020 ◽  
Vol 9 (11) ◽  
pp. 3536 ◽  
Author(s):  
Gysbert-Botho van Setten ◽  
Christophe Baudouin ◽  
Jutta Horwath-Winter ◽  
Daniel Böhringer ◽  
Oliver Stachs ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
Eye Drops ◽  
Artificial Tears ◽  
Ocular Surface Disease Index

The aim of the HYLAN M study was to investigate if symptoms and/or signs of patients suffering from severe dry eye disease (DED) can be improved by substituting individually optimized artificial tear therapy by high molecular weight hyaluronan (HMWHA) eye drops. In this international, multicenter study, patients with symptoms of at least ocular surface disease index (OSDI) 33 and corneal fluorescein staining (CFS) of at least Oxford grade 3 were included. A total of 84 per-protocol patients were randomized in two study arms. The control group continued to use their individual optimum artificial tears over the study period of eight weeks; in the verum group, the artificial tears were substituted by eye drops containing 0.15% HMWHA. At the week 8 visit, the average OSDI of the verum group had improved by 13.5 as compared to the control group (p = 0.001). The best corrected visual acuity (BCVA) had improved by 0.04 logMAR (p = 0.033). CFS, tear film break-up time (TBUT), Schirmer I, lid wiper epitheliopathy (LWE), mucocutaneous junction (Yamaguchi score), and tear osmolarity were not significantly different between the verum and control groups (p > 0.050). We conclude that for most patients with severe DED, 0.15% HMWHA eye drops provide excellent improvement of symptoms without impairment of dry eye signs.

scholarly journals Autologous serum eye drops for dry eye

2013 ◽  
Author(s):  
Qing Pan ◽  
Adla Angelina ◽  
Andrea Zambrano ◽  
Michael Marrone ◽  
Walter J Stark ◽  
...  
Keyword(s):  
Dry Eye ◽  
Autologous Serum ◽  
Eye Drops ◽  
Serum Eye Drops

Autologous Serum Eye Drops for the Treatment of Dry Eye Diseases

Cornea ◽  
2008 ◽  
Vol 27 (Suppl 1) ◽  
pp. S25-S30 ◽  
Author(s):  
Takashi Kojima ◽  
Akihiro Higuchi ◽  
Eiki Goto ◽  
Yukihiro Matsumoto ◽  
Murat Dogru ◽  
...  
Keyword(s):  
Dry Eye ◽  
Eye Diseases ◽  
Autologous Serum ◽  
Eye Drops ◽  
Serum Eye Drops

scholarly journals Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

In Vivo ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 931-938 ◽  
Author(s):  
FRANCESCO SEMERARO ◽  
ELIANA FORBICE ◽  
GIUSEPPE NASCIMBENI ◽  
MARCO TAGLIETTI ◽  
VITO ROMANO ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Sjögren Syndrome ◽  
Autologous Serum ◽  
Sjogren Syndrome ◽  
Eye Drops ◽  
In Vivo Confocal Microscopy ◽  
Serum Eye Drops

Effectiveness of Autologous Serum Eye Drops Combined With Punctal Plugs for the Treatment of Sjögren Syndrome–Related Dry Eye

Cornea ◽  
2015 ◽  
Vol 34 (10) ◽  
pp. 1214-1220 ◽  
Author(s):  
Ying Liu ◽  
Masatoshi Hirayama ◽  
Xin Cui ◽  
Samuel Connell ◽  
Tetsuya Kawakita ◽  
...  
Keyword(s):  
Dry Eye ◽  
Sjögren Syndrome ◽  
Autologous Serum ◽  
Sjogren Syndrome ◽  
Eye Drops ◽  
Punctal Plugs ◽  
Serum Eye Drops

Efficacy of Single-dose Intra-articular Injection of High-molecular-weight Hyaluronic Acid in Patients suffering from Primary Osteoarthritis of Knee

2017 ◽  
Vol 28 (3) ◽  
pp. 89-94 ◽  
Author(s):  
N Romi Singh ◽  
Jotin S Yengkhom ◽  
MS Chongreilen Chiru ◽  
Kaustav B Thakur ◽  
Utpalendu Debnath
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Single Dose ◽  
High Molecular Weight ◽  
Control Group ◽  
Study Group ◽  
Osteoarthritis Of Knee ◽  
American College Of Rheumatology ◽  
Primary Osteoarthritis ◽  
Study Population

ABSTRACT Aim To find the effectiveness of single-dose intra-articular (IA) injection of high-molecular-weight hyaluronic acid (HMWHA) in patients suffering from primary osteoarthritis (OA) of knee. Study design A randomized control trial. Duration of the study One-and-a-half years, commencing from October 2014. Settings Physical Medicine and Rehabilitation (PMR) Department, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. Study population All patients suffering from OA knee, who fulfilled the American College of Rheumatology (ACR) criteria for classification of idiopathic OA knee and attending the department during the study period. Materials and methods Sixty-five patients were randomized to receive either visco-supplementation with single-dose IA injection of HMWHA (study group) or methylprednisolone (control group) and follow-up was done at 1, 3, and 6 months. Outcome measures were done with Western Ontario and McMaster University (WOMAC) and visual analog scale (VAS) for pain. Results Both the groups showed significant improvement in both WOMAC and VAS pain score at the end of 3 months. But at the end of 6 months, improvement in terms of WOMAC (p = 0.09) and VAS pain (p = 0.07) scores in control group was not significant, whereas the study group maintained statistically significant improvement. Conclusion A single dose of IA HMWHA is effective in reducing pain and disability in patients with primary OA of knee. How to cite this article Yengkhom JS, Nongmaithem RS, Chiru MSC, Thakur KB, Debnath U. Efficacy of Single-dose Intra-articular Injection of High-molecular-weight Hyaluronic Acid in Patients suffering from Primary Osteoarthritis of Knee. Indian J Phy Med Rehab 2017;28(3):89-94.

scholarly journals Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment

Micromachines ◽  
2016 ◽  
Vol 7 (7) ◽  
pp. 113 ◽  
Author(s):  
Takao Yasui ◽  
Jumpei Morikawa ◽  
Noritada Kaji ◽  
Manabu Tokeshi ◽  
Kazuo Tsubota ◽  
...  
Keyword(s):  
Dry Eye ◽  
Autologous Serum ◽  
Eye Drops ◽  
Serum Eye Drops
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