Prenatal Imaging Features and Postnatal Factors Associated with Gastrointestinal Morbidity in Congenital Diaphragmatic Hernia

2019 ◽  
Vol 47 (4) ◽  
pp. 252-260 ◽  
Author(s):  
Mariatu A. Verla ◽  
Candace C. Style ◽  
Amy R. Mehollin-Ray ◽  
Sara C. Fallon ◽  
Adam M. Vogel ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Imaging Features ◽  
Factors Associated ◽  
Prenatal Imaging ◽  
Postnatal Factors

Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia

2018 ◽  
Vol 48 (6) ◽  
pp. 2112-2121 ◽  
Author(s):  
Enrico Danzer ◽  
Casey Hoffman ◽  
Jo Ann D’Agostino ◽  
Judith S. Miller ◽  
Lindsay N. Waqar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Factors Associated

Congenital Diaphragmatic Hernia Repair

2018 ◽  
Author(s):  
Jagroop Mavi ◽  
Anne C. Boat ◽  
Senthilkumar Sadhasivam ◽  
Catherine P. Seipel
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Pleural Cavity ◽  
Pulmonary Vasculature ◽  
Fetal Magnetic Resonance Imaging ◽  
Fetal Ultrasound ◽  
Ventilatory Parameters ◽  
Anesthetic Considerations ◽  
Prenatal Imaging ◽  
Medical Stabilization

Congenital diaphragmatic hernia is an embryologic defect in diaphragm formation that allows abdominal contents to enter into the fetal pleural cavity, resulting in ipsilateral lung compression, pulmonary hypoplasia, and abnormal pulmonary vasculature. Though diagnosis is frequently made on prenatal imaging, the diagnosis should be considered in any newborn with respiratory distress. Prenatal predictors of defect severity include evaluation of observed-to-expected lung volumes on fetal magnetic resonance imaging and lung-to-head ratio on fetal ultrasound. Treatment focuses on medical stabilization, including optimization of oxygenation and ventilation, followed by surgical repair. Anesthetic considerations for these patients include management of coexisting cardiac disease and ventilatory parameters, in addition to standard neonatal anesthetic considerations.

scholarly journals Prenatal Factors Associated with Postnatal Brain Injury in Infants with Congenital Diaphragmatic Hernia

2017 ◽  
Vol 39 (3) ◽  
pp. 558-562 ◽  
Author(s):  
R. Radhakrishnan ◽  
S.L. Merhar ◽  
W. Su ◽  
B. Zhang ◽  
P. Burns ◽  
...  
Keyword(s):  
Brain Injury ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Postnatal Brain ◽  
Factors Associated ◽  
Prenatal Factors

scholarly journals Outcome of Congenital Diaphragmatic Hernia: A Single Center Experience

2020 ◽  
Vol 8 (4) ◽  
pp. 29
Author(s):  
Jayasree Chandramati ◽  
Lakshmi S Nair ◽  
Smriti M Menon ◽  
Ashwin Prabhu ◽  
Mohan Abraham ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Retrospective Cohort ◽  
Prognostic Markers ◽  
Fetal Lung ◽  
Left Ventricular ◽  
Management Guidelines ◽  
Factors Associated ◽  
Remarkable Improvement ◽  
Single Center Experience

Background: Congenital diaphragmatic hernia (CDH) is a complex malformation with a challenging perioperative care. The outcome is still not very impressive in developing countries despite its remarkable improvement in developed countries.Methods: We analyzed outcomes, and factors associated with morbidity and mortality of 120 newborns with CDH, managed at our institution.Results: The overall survival was 73.4%. Chromosomal aberrations, pneumothorax within 24 hours, left ventricular hypoplasia, biventricular dysfunction, fetal lung to head ratio (LHR)Conclusion: This is the largest series of a retrospective cohort study of CDH reported in India. We have briefly reviewed the topic and the management guidelines along with prognostic markers derived from this study.

Predicting Full Enteral Feeding in the Postoperative Period in Infants with Congenital Diaphragmatic Hernia

2017 ◽  
Vol 27 (05) ◽  
pp. 431-436 ◽  
Author(s):  
Miryam Triana ◽  
Rosario Madero ◽  
Steven Abrams ◽  
Leopoldo Martinez ◽  
Maria Amesty ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Congenital Diaphragmatic Hernia ◽  
Hospital Discharge ◽  
Diaphragmatic Hernia ◽  
Enteral Feeding ◽  
Postoperative Period ◽  
Surgical Repair ◽  
Factors Associated ◽  
Enteral Feedings ◽  
Full Enteral Feeding

Introduction The objective of the study is to examine the factors associated with time to achieve full enteral feeding after repair of congenital diaphragmatic hernia. Materials and Methods Demographic, clinical, and therapeutic data were retrospectively assessed, and uni- and multivariate Cox regression were performed to examine factors predictive of achieving full enteral feeding that was defined as time to achieve120 mL/kg/d after surgical repair. Results Of 78 infants, 66 underwent intervention before hospital discharge. All infants who survived had reached full enteral feeding at the time of hospital discharge by a median of 22 days (range: 2–119 days) after surgery and 10 days (range: 1–91) after initiation of postoperative enteral feedings. Independent risk factors associated with a longer time to reach full enteral feeding achievement included gastroesophageal reflux and days of antibiotics in the postoperative period. Daily stool passage preoperatively predicted earlier enteral tolerance. Conclusion Infants who survive congenital diaphragmatic hernia generally are able to achieve full enteral feedings after surgical repair. A longer time to full feeding is needed in the most severe cases, but some specific characteristics can be used to help identify patients at higher risk. Although some of these characteristics are unavoidable, others including rational antibiotic usage and active gastroesophageal reflux prevention and treatment are feasible and may improve enteral tolerance.

scholarly journals Early population-based outcomes of infants born with congenital diaphragmatic hernia

2018 ◽  
Vol 103 (6) ◽  
pp. F517-F522 ◽  
Author(s):  
Anna-May Long ◽  
Kathryn J Bunch ◽  
Marian Knight ◽  
Jennifer J Kurinczuk ◽  
Paul D Losty
Keyword(s):  
Prognostic Factors ◽  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
International Studies ◽  
Factors Associated ◽  
Female Sex ◽  
Pulmonary Vasodilators ◽  
The Uk

PurposeThis study aims to describe short-term outcomes of live-born infants with congenital diaphragmatic hernia (CDH) and to identify prognostic factors associated with early mortality.DesignA prospective population cohort study was undertaken between April 2009 and September 2010, collecting data on live-born infants with CDH from all 28 paediatric surgical centres in the UK and Ireland using an established surgical surveillance system. Management and outcomes are described. Prognostic factors associated with death before surgery are explored.ResultsTwo hundred and nineteen live-born infants with CDH were reported within the data collection period. There were 1.5 times more boys than girls (n=133, 61%). Thirty-five infants (16%) died without an operation. This adverse outcome was associated with female sex (adjusted OR (aOR) 3.96, 95% CI 1.66 to 9.47), prenatal diagnosis (aOR 4.99, 95% CI 1.31 to 18.98), and the need for physiological support in the form of inotropes (aOR 9.96, 95% CI 1.19 to 83.25) or pulmonary vasodilators (aOR 4.09, 95% CI 1.53 to 10.93). Significant variation in practice existed among centres, and some therapies potentially detrimental to infant outcomes were used, including pulmonary surfactant in 45 antenatally diagnosed infants (34%). Utilisation of extracorporeal membrane oxygenation was very low compared with published international studies (n=9/219, 4%). Postoperative 30-day survival was 98% for 182 infants with CDH who were adequately physiologically stabilised and underwent surgery.ConclusionThis is the first British Isles population-based study reporting outcome metrics for infants born with CDH. 16% of babies did not survive to undergo surgery. Factors associated with poor outcome included female sex and prenatal diagnosis. Early postoperative survival in those who underwent surgical repair was excellent.

Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes

2019 ◽  
Vol 49 (5) ◽  
pp. 593-599 ◽  
Author(s):  
Edward R. Oliver ◽  
Suzanne E. DeBari ◽  
Samantha E. Adams ◽  
Ryne A. Didier ◽  
Steven C. Horii ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Prenatal Imaging
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