The Loss in Expectation of Life due to Early-Onset Mild Cognitive Impairment and Early-Onset Dementia in Norway

2019 ◽  
Vol 47 (4-6) ◽  
pp. 355-365 ◽  
Author(s):  
Bjørn Heine Strand ◽  
Anne-Brita Knapskog ◽  
Karin Persson ◽  
Trine Holt Edwin ◽  
Espen Bjertness ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Early Onset Dementia

scholarly journals Early onset dementia: Clinical utility of cerebrospinal fluid amyloidβ and tau measures in diagnosing mild cognitive impairment

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Akram A. Hosseini ◽  
Thomas Brown ◽  
Luca Mannino ◽  
Bruno Gran ◽  
Kehinde Junaid ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Clinical Utility ◽  
Early Onset Dementia

scholarly journals Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors

Geriatrics ◽  
2016 ◽  
Vol 1 (2) ◽  
pp. 11 ◽  
Author(s):  
Miguel Tábuas-Pereira ◽  
Inês Baldeiras ◽  
Diana Duro ◽  
Beatriz Santiago ◽  
Maria Ribeiro ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Late Onset ◽  
Conversion Rates

[P1-338]: SMELL IDENTIFICATION IMPAIRMENT IN EARLY ONSET ALZHEIMER's DIASEASE AND MILD COGNITIVE IMPAIRMENT

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P385-P386
Author(s):  
Latha Velayudhan ◽  
Frances Morkeh-Wilson ◽  
Emily Penny ◽  
Amy Gasper ◽  
Terry Brugha ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Smell Identification

scholarly journals Excessive Seizure Clusters in an Otherwise Well-Controlled Epilepsy as a Possible Hallmark of Untreated Vitamin B6-Responsive Epilepsy due to a Homozygous PLPBP Missense Variant

2019 ◽  
Vol 08 (04) ◽  
pp. 222-225
Author(s):  
Jessika Johannsen ◽  
Tatjana Bierhals ◽  
Philipp Deindl ◽  
Laura Hecher ◽  
Katharina Hermann ◽  
...  
Keyword(s):  
Learning Disabilities ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Vitamin B6 ◽  
Seizure Control ◽  
Missense Variant ◽  
Male Adolescent ◽  
Anxiety States ◽  
Good Seizure Control

AbstractRecently, mutations in the PLPBP gene were described as a novel cause for vitamin B6-responsive epilepsy. We report the outcome in case of a male adolescent with a novel homozygous missense variant in PLPBP who was never treated with pyridoxine until the age of 16 years. He presented with only mild cognitive impairment and an early-onset, well-controlled epilepsy. In our patient, excessive seizure clusters and anxiety states occurred intermittently, suggesting that the combination might be a hallmark in untreated patients. Thus, mutations in PLPBP should be addressed even in adolescent patients with only mild learning disabilities and relatively good seizure control over the years.

scholarly journals BIOFACE: A prospective study of risk factors, cognition and biomarkers in a cohort of individuals with early‐onset mild cognitive impairment at Fundació ACE

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Ester Esteban‐De Antonio ◽  
Alba Pérez‐Cordón ◽  
Silvia Gil ◽  
Amanda Cano ◽  
Adelina Orellana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Early Onset ◽  
A Prospective Study

scholarly journals Fluid intelligence and its neural correlates in early onset mild cognitive impairment

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Chiara Carbone ◽  
Elisa Bardi ◽  
Maria Giulia Corni ◽  
Luigi Fiondella ◽  
Simone Salemme ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Fluid Intelligence ◽  
Neural Correlates

scholarly journals Working towards inclusion: Creating technology for and with people living with mild cognitive impairment or dementia who are employed

Dementia ◽  
2021 ◽  
pp. 147130122110518
Author(s):  
Karan Shastri ◽  
Jennifer Boger ◽  
Sheida Marashi ◽  
Arlene Astell ◽  
Erica Dove ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lessons Learned ◽  
Early Onset Dementia ◽  
Workplace Experiences ◽  
Use Of Technology ◽  
People With Dementia ◽  
Care Partners ◽  
Dementia Research

Earlier diagnosis and longer working careers is resulting in more individuals being identified as having Mild Cognitive Impairment or Early Onset Dementia (MCI/EOD) when they are still in the workforce. While there is growing interest in the dementia research community and beyond to develop technologies to support people with dementia, the use of technology for and by people with MCI/EOD in the workplace has had very little attention. This paper presents a two-part study involving interviews and participatory sessions to begin to understand the workplace experiences and the role of technology among people living with MCI/EOD. We present our findings from working with seven people with MCI/EOD and two care partners to explore technology design. Our results indicate several similarities as well as a few differences between MCI/EOD and later-onset dementia with respect to challenges using technology and design considerations for supporting engagement and use of technology. Lessons learned through the process of working with people with MCI/EOD through participatory methods is presented along with recommendations to foster an inclusive, respectful, and empowering experience for participants with MCI/EOD.

scholarly journals BIOFACE: A Prospective Study of Risk Factors, Cognition, and Biomarkers in a Cohort of Individuals with Early-Onset Mild Cognitive Impairment. Study Rationale and Research Protocols

2021 ◽  
pp. 1-17
Author(s):  
Ester Esteban de Antonio ◽  
Alba Pérez-Cordón ◽  
Silvia Gil ◽  
Adelina Orellana ◽  
Amanda Cano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Brain Mri ◽  
Point Of View ◽  
Non Invasive ◽  
History Of ◽  
Multimodal Biomarkers ◽  
A Prospective Study

Background: Mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) diagnosis is based on cerebrospinal fluid (CSF) or neuroimaging biomarkers. Currently, non-invasive and inexpensive blood-based biomarkers are being investigated, such as neuronal-derived plasma exosomes (NPEs). Neuroinflammation and early vascular changes have been described in AD pathogenesis and can be traced in plasma and NPEs. However, they have not been studied in early onset MCI (EOMCI). Objective: To describe the rationale, design, and baseline characteristics of the participants from the BIOFACE cohort, a two-year observational study on EOMCI conducted at Fundació ACE. The study goal is to characterize the different phenotypes from a clinical, neuropsychological, and biomarker point of view and to investigate the CSF and plasma proteomics as well as the role of NPEs as early biomarkers of AD. Methods: Participants underwent extended neurological and neuropsychological batteries, multimodal biomarkers including brain MRI, blood, saliva, CSF, anthropometric, and neuro-ophthalmological examinations. Results: Ninety-seven patients with EOMCI were recruited. 59.8%were women. Mean age at symptom onset was 57 years; mean MMSE was 28. First degree and presenile family history of dementia was present in 60.8%and 15.5%, respectively. Depressive and anxiety disorders along with vascular risk factors were the most frequent comorbidities. 29%of participants were APOE ɛ4 carriers, and 67%showed a CSF normal ATN profile. Conclusion: BIOFACE is a two-year study of clinical, cognition, and biomarkers that will shed light on the physiopathology and the potential utility of plasma and NPEs as non-invasive early diagnostic and prognostic biomarkers in people younger than 65 years.

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