scholarly journals Understanding the Radial Force of Stroke Thrombectomy Devices to Minimize Vessel Wall Injury: Mechanical Bench Testing of the Radial Force Generated by a Novel Braided Thrombectomy Assist Device Compared to Laser-Cut Stent Retrievers in Simulated MCA Vessel Diameters

2019 ◽  
Vol 8 (2-6) ◽  
pp. 206-214 ◽  
Author(s):  
Jeffrey M. Katz ◽  
Abdullah M. Hakoun ◽  
Amir R. Dehdashti ◽  
Alex B. Chebl ◽  
Vikram Janardhan ◽  
...  
Keyword(s):  
Vessel Wall ◽  
Testing Machine ◽  
Radial Force ◽  
Outer Diameter ◽  
Radial Compression ◽  
Assist Devices ◽  
Stent Retrievers ◽  
Wall Injury ◽  
Bench Testing ◽  
The Impact

Background: Recent reports have raised various concerns about the risk of vessel wall injury while withdrawing current laser-cut stent retrievers during active strut apposition to the vessel walls. The development of braided thrombectomy assist devices in conjunction with aspiration systems may be gentler on the fragile brain vessels and more optimized with regard to the radial force (RF) for vessel diameters of proximal (M1) and distal (M2) large vessel occlusions (LVOs). Methods: Mechanical bench testing of the RF was performed using a radial compression station mounted on a tensile testing machine. The total RF in newtons (N) generated in vessels with diameters ranging from 2.25 to 3 mm as seen in proximal LVOs (∼M1), and in vessel diameters ranging from 1.5 to 2.24 mm as seen in distal LVOs (∼M2), was measured. The outer diameter of each stent was recorded, and an RF ≤1 N was grouped as “low,” while an RF >1 N was grouped as “high” for this analysis. Results: The total RFs of all laser-cut stent retrievers were all higher in the simulated M2 vessels (>1 N) than in the M1 vessels (<1 N), whereas the total RFs of the braided thrombectomy assist devices were uniformly low in both the simulated M1 and the simulated M2 vessels. Conclusions: Novel braided thrombectomy assist devices in conjunction with aspiration systems have lower RFs than existing laser-cut stent retrievers in M1 and M2 vessel diameters. Further in vivo studies are needed to delineate the impact of lowering the RF on vessel wall integrity.

Active push deployment technique improves stent/vessel-wall interaction in endovascular treatment of acute stroke with stent retrievers

2016 ◽  
Vol 9 (3) ◽  
pp. 253-256 ◽  
Author(s):  
Martin Wiesmann ◽  
Marc-Alexander Brockmann ◽  
Sarah Heringer ◽  
Marguerite Müller ◽  
Arno Reich ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Clinical Experience ◽  
Vessel Wall ◽  
Radial Force ◽  
Vitro Experiment ◽  
In Vitro Experiment ◽  
Stent Retrievers ◽  
Wall Interaction ◽  
The Cost

BackgroundThe optimal interaction between stent struts and thrombus is crucial for successful revascularization in endovascular stroke therapy with stent retrievers. Deploying the stent retriever by actively pushing it into the thrombus increases the radial force with which the stent struts expand into the thrombus.ObjectiveTo examine the active push deployment (APD) technique in an in vitro model and present our clinical experience with this technique.MethodsIn an in vitro experiment we investigated the configuration of a Solitaire and a Trevo ProVue device (both 4×20 mm), depending on whether the devices were deployed using the APD technique or simple unsheathing. We retrospectively assessed the effectiveness and safety of this technique by analyzing 130 patients with large vessel occlusions (carotid T or M1 segment of the middle cerebral artery), who received endovascular treatment with a Trevo device (4×20 mm) that was deployed using the APD technique.ResultsIn vitro experiment: the APD technique improved apposition of the devices to the vessel wall. There was widening of 30% (Trevo) and 19% (Solitaire) at the cost of a shortening of 5% and 4%, respectively, when the devices were deployed in a carotid T model. Clinical study: the revascularization rate (Thrombolysis in Cerebral Infarction ≥2b) with the Trevo device was 90%. There were no retriever-associated dissections or perforations in 278 retrieval maneuvers.ConclusionsThe APD technique improves apposition of the tested devices to the vessel wall. The widening effect comes at the cost of minimal shortening of the devices. Our clinical experience shows that using the APD technique to deploy the Trevo device is effective and safe.

scholarly journals Experimental evaluation of stent retrievers’ mechanical properties and effectiveness

2016 ◽  
Vol 9 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Paolo Machi ◽  
Franck Jourdan ◽  
Dominique Ambard ◽  
Cedric Reynaud ◽  
Kyriakos Lobotesis ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Vessel Wall ◽  
Large Diameter ◽  
Mechanical Tests ◽  
Radial Force ◽  
Functional Tests ◽  
Clot Removal ◽  
Stent Retrievers ◽  
Thrombus Removal

BackgroundFive randomized controlled trials recently appeared in the literature demonstrating that early mechanical thrombectomy in patients with acute ischemic stroke is significantly related to an improved outcome. Stent retrievers are accepted as the most effective devices for intracranial thrombectomy.ObjectiveTo analyze the mechanical properties of stent retrievers, their behavior during retrieval, and interaction with different clots and to identify device features that might correlate with the effectiveness of thrombus removal.Materials and methodsAll stent retrievers available in France up to June 2015 were evaluated by mechanical and functional tests aimed at investigating the variation of their radial force and their behavior during retrieval. Devices were also tested during in vitro thrombectomies using white and red experimental thrombi produced with human blood. Functional tests and in vitro thrombectomies were conducted using a rigid 3D printed vascular model.ResultsMechanical tests showed a variation in radial force during retrieval for each stent. A constant radial force during retrieval was related to continuous cohesion over the vessel wall and a higher rate of clot removal efficacy. All stent retrievers failed when interacting with white large thrombi (diameter ≥6 mm).ConclusionsNone of the tested devices were effective in removing white clots of large diameter (≥6 mm). Constant radial force during retrieval allows constant cohesion to the vessel wall and pressure over the clot; such features allow for a higher rate of clot removal.

Gene Induction in Vessel Wall Injury

1993 ◽  
Vol 70 (01) ◽  
pp. 180-183 ◽  
Author(s):  
Mark B Taubman
Keyword(s):  
Vessel Wall ◽  
Gene Induction ◽  
Wall Injury

The Effects of Heparin and Annexin V on Fibrin Accretion after Injury in the Jugular Veins of Rabbits

1993 ◽  
Vol 69 (03) ◽  
pp. 227-230 ◽  
Author(s):  
J Van Ryn-McKenna ◽  
H Merk ◽  
T H Müller ◽  
M R Buchanan ◽  
W G Eisert
Keyword(s):  
Vessel Wall ◽  
Thrombin Generation ◽  
Antithrombin Iii ◽  
Specific Effect ◽  
Annexin V ◽  
Inhibitory Effect ◽  
Jugular Veins ◽  
Prothrombinase Complex ◽  
Wall Injury

SummaryWe compared the relative abilities of unfractionated heparin and annexin V to prevent fibrin accretion onto injured jugular veins in vivo. Heparin was used to accelerate the inhibition of thrombin by antithrombin III, and annexin V was used to inhibit the assembly of the prothrombinase complex on phospholipid surfaces, thereby blocking thrombin generation. Rabbit jugular veins were isolated in situ, a 2 cm segment was injured by perfusing it with air, and then blood flow was re-established. Five minutes later, each rabbit was injected with heparin (20 U/kg) or annexin V (0.3 mg/kg) and then with 125I-fibrinogen. The amount of 125I-fibrin accumulation onto each injured vessel wall segment was measured 4 h later. Each injured vessel was completely deendothelialized as a result of the air perfusion as demonstrated by electron microscopy. 125I-fibrin accretion onto the injured jugular veins was enhanced 2.4-fold as compared to the uninjured veins in sham-operated animals. Heparin treatment did not reduce fibrin accretion, whereas, annexin V treatment decreased fibrin accretion by 60%, p <0.05. This latter effect was achieved without sustained circulating anticoagulation. Additional experiments confirmed that the inhibitory effect of annexin V on fibrin accretion was associated with a surface specific effect, since more annexin V bound to the injured jugular vein segments as compared to the non-injured jugular veins. We conclude that, i) mild vessel wall injury (selective de-endothelialization) in veins results in a thrombogenic vessel wall; ii) the thrombogenecity of which is not inhibited by prophylactic doses of heparin; but iii) is inhibited by annexin V, which binds to injured vessel wall surface, and inhibits thrombin generation independently of antithrombin III.

scholarly journals Effects of temperature and impactor nose diameter on the impact behavior of PA6 and PP thermoplastic composites

2018 ◽  
Vol 51 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Akar Dogan ◽  
Yusuf Arman
Keyword(s):  
Load Capacity ◽  
Testing Machine ◽  
Polyamide 6 ◽  
Impact Testing ◽  
Impact Behavior ◽  
Thermoplastic Composites ◽  
Test Machine ◽  
Effects Of Temperature ◽  
Impact Energies ◽  
The Impact

In this study, the effects of temperature and impactor nose diameter on the impact behavior of woven glass-reinforced polyamide 6 (PA6) and polypropylene (PP) thermoplastic composites were investigated experimentally. Impact energies are chosen as 10, 30, 50, 70, 90, 110, 130, and 170 J. The thickness of composite materials is 4 mm. Impact tests were performed using a drop weight impact testing machine, CEAST-Fractovis Plus, and the load capacity of test machine is 22 kN. Hemispherical impactor nose diameter of 12, 7, and 20 mm were used as an impactor. The tests are conducted at room temperature (20°C and 75°C). As a result, the PP composites of the same thickness absorbed more energy than PA6 composites. The amount of absorbed energy of PP and PA6 composites decreased with temperature.

Direct Outer Ring Cooling of a High Speed Jet Engine Mainshaft Ball Bearing: Experimental Investigation Results

2010 ◽  
Author(s):  
Peter Gloeckner ◽  
Klaus Dullenkopf ◽  
Michael Flouros
Keyword(s):  
Power Dissipation ◽  
High Speed ◽  
Ball Bearing ◽  
Operating Conditions ◽  
Outer Ring ◽  
Outer Diameter ◽  
Propulsion Systems ◽  
Jet Engine ◽  
Power Loss Reduction ◽  
The Impact

Operating conditions in high speed mainshaft ball bearings applied in new aircraft propulsion systems require enhanced bearing designs and materials. Rotational speeds, loads, demands on higher thrust capability, and reliability have increased continuously over the last years. A consequence of these increasing operating conditions are increased bearing temperatures. A state of the art jet engine high speed ball bearing has been modified with an oil channel in the outer diameter of the bearing. This oil channel provides direct cooling of the outer ring. Rig testing under typical flight conditions has been performed to investigate the cooling efficiency of the outer ring oil channel. In this paper the experimental results including bearing temperature distribution, power dissipation, bearing oil pumping and the impact on oil mass and parasitic power loss reduction are presented.

Effect of Hydrogen Content on Impact Property of A357 Alloy

2011 ◽  
Vol 704-705 ◽  
pp. 1201-1204 ◽  
Author(s):  
Yang Li ◽  
Zheng Bing Xu ◽  
Jian Min Zeng
Keyword(s):  
Crack Propagation ◽  
Hydrogen Content ◽  
Impact Test ◽  
Testing Machine ◽  
Initial Crack ◽  
Impact Testing ◽  
Total Absorption ◽  
A357 Alloy ◽  
Absorption Energy ◽  
The Impact

The impact specimens with different hydrogen contents were solution treated at 540±3°C for 12h; water quenched at 60-100°C; and aged at 165±1°C for 6h. The impact test was carried out at Roell450 pendulum impact testing machine. The impact test results show that the impact energy has strong relation with the hydrogen content. The total absorption energy increases with the increasing of hydrogen content. The crack propagation energy Avp and present larger proportion than the initial crack energy Avi in the total absorption energy Av. The number of the pinholes increases and the pinholes turn from smaller irregular ones into sub-circular shape ones. The specimen with irregular sub-circular pinholes has larger KI, and has more crack propagation resistance.

scholarly journals Intracranial Arterial Dissection Related to HIV Infection

2005 ◽  
Vol 11 (4) ◽  
pp. 387-391 ◽  
Author(s):  
D. Lefeuvre ◽  
L. Liebenberg ◽  
A. Taylor
Keyword(s):  
Human Immunodeficiency Virus ◽  
Subarachnoid Haemorrhage ◽  
Vessel Wall ◽  
False Aneurysm ◽  
Hiv Positive ◽  
Pathological Study ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
The Right ◽  
Wall Injury

There are many reasons for patients infected with human immunodeficiency virus (HIV) to develop cerebrovascular disease. The HIV virus itself however may be a cause of vessel wall pathology. We present a clinical and pathological study of a patient who was HIV positive and presented with a subarachnoid haemorrhage. Cerebral angiography and later histology confirm that there was extensive vessel wall injury with dissection and a false aneurysm of the right middle cerebral artery.

scholarly journals The Impact of Chlorhexidine Mouth Rinse on the Bond Strength of Polycarbonate Orthodontic Brackets

2014 ◽  
Vol 15 (6) ◽  
pp. 688-692 ◽  
Author(s):  
Sukumaran Anil ◽  
Farouk Ahmed Hussein ◽  
Mohammed Ibrahim Hashem ◽  
Elna P Chalisserry
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Testing Machine ◽  
Test Group ◽  
Orthodontic Brackets ◽  
Control Group ◽  
Mouth Rinse ◽  
Significant Difference ◽  
Bond Strengths ◽  
The Impact

ABSTRACT Objective The purpose of the current in-vivo study was to assess the effect of using 0.12% chlorhexidine (CHX) mouth rinse, before bonding, on shear bond strength of polycarbonate brackets bonded with composite adhesive. Subjects and methods Eighteen orthodontic patients with a mean age 21.41 ± 1.2 years, who were scheduled to have 2 or more first premolars extracted, were included in this study. Patients were referred for an oral prophylaxis program which included, in part, the use of a mouth rinse. Patients were divided into 2 groups, a test group of 9 patients who used 0.12% CHX gluconate mouth rinse twice daily and a control group of 9 patients who used a mouth rinse without CHX, but with same color. After 1 week, polycarbonate brackets were bonded to first premolars with Transbond XT composite adhesive. Premolars were extracted after 28 days and tested for shear bond strength on a universal testing machine. Student's t-test was used to compare shear bond strengths of both groups. Results No statistically significant difference was found in bond strengths’ values between both groups. The test group (with CHX) has mean shear bond strength of 14.21 ± 2.42 MPa whereas the control group (without CHX) revealed a mean strength of 14.52 ± 2.31 MPa. Conclusion The use of 0.12% CHX mouth rinse, for one week before bonding, did not affect the shear bond strength of polycarbonate brackets bonded with Transbond composite. Furthermore, these brackets showed clinically acceptable bond strength. How to cite this article Hussein FA, Hashem MI, Chalisserry EP, Anil S. The Impact of Chlorhexidine Mouth Rinse on the Bond Strength of Polycarbonate Orthodontic Brackets. J Contemp Dent Pract 2014;15(6):688-692.

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