scholarly journals Choroidal Nevus and Melanoma in Patients with Oculocutaneous Albinism

2019 ◽  
Vol 6 (1) ◽  
pp. 31-34
Author(s):  
Pukhraj Rishi ◽  
Mihir Trivedi ◽  
Kummamuri Sreelakshmi
Keyword(s):  
Histopathological Examination ◽  
Choroidal Melanoma ◽  
Case Series ◽  
Oculocutaneous Albinism ◽  
Large Tumor ◽  
Mixed Cell ◽  
Asian Patients ◽  
Melanocytic Lesions ◽  
Choroidal Nevus ◽  
The Right

Background: There are limited reports of uveal “melanocytic” lesions in patients with oculocutaneous albinism, with no reports from Asia. Objectives: In this study, we report 3 eyes with uveal “melanocytic” lesions in Asian patients with oculocutaneous albinism. Methods: Retrospective small case series. Three eyes of 2 Asian patients with oculocutaneous albinism were included. Case 1 was a 54-year-old female who presented with juxtapapillary choroidal melanoma and underwent enucleation. Case 2 was a 39-year-old male with pigmented choroidal nevus in the right eye and suspicious nevus/choroidal variegation in the left eye. Results: For case 1, metastatic workup including ultrasound of the abdomen, liver function test, and chest X-ray was unremarkable. Magnetic resonance imaging of the cranium ruled out extraocular extension. The left eye was enucleated due to the large tumor size and poor visual potential, and histopathological examination confirmed the diagnosis of choroidal melanoma with mixed cell type. At the last follow-up 6 months after enucleation, there was no evidence of metastasis. Case 2 was observed. Conclusion: Pigmented choroidal nevus and melanoma are rarely observed in patients with oculocutaneous albinism.

scholarly journals Spontaneous Necrosis of a Large Choroidal Melanoma: Unusual Presentation in a 49-Year-Old Male

2019 ◽  
Vol 6 (3) ◽  
pp. 174-179
Author(s):  
Carmen Baumann ◽  
Danilo Iannetta ◽  
Sarah E. Coupland ◽  
Carl Groenewald ◽  
Mandagere Vishwanath ◽  
...  
Keyword(s):  
Choroidal Melanoma ◽  
Vitreous Haemorrhage ◽  
Tumour Mass ◽  
Mixed Cell ◽  
Ocular Tissues ◽  
Complete Lysis ◽  
Pars Plana ◽  
The Right ◽  
Good Vision ◽  
Viable Tumour

Purpose: To demonstrate a case of massive vitreous haemorrhage obscuring the underlying diagnosis of a large mixed-cell choroidal melanoma which had undergone spontaneous necrosis. Case Report: A 49-year-old man in good general health suddenly lost vision in his right eye due to an extensive vitreous haemorrhage 1 day after a workout at the gym. He reported good vision prior to that without any symptoms of flashes, floaters, or shadows. He was referred to the vitreoretinal department of a tertiary eye hospital, where he presented with a drop in vision to light perception only in the right phakic eye. Pars plana vitrectomy was performed in the right eye, which revealed intraoperatively massive retinal ischemia and choroidal haemorrhage, but no obvious tumour mass that could have been biopsied. The vitrectomy cassette specimen was sent for histopathology, where “ghost-like” melanoma cells were identified. The eye was subsequently enucleated, revealing an extensively necrotic and haemorrhagic choroidal melanoma of mixed cell type with only small viable tumour foci at the base and almost complete lysis of the detached retina. Conclusion: Some uveal melanomas (UMs) undergo spontaneous necrosis due to rapid growth, with the centre of the tumour outstripping its established blood supply in the “watershed area” of the eye, and becoming hypoxic with associated necrosis of intraocular structures. Such UMs are often associated with haemorrhage and/or inflammation and usually cause significant destruction of ocular tissues, resulting in enucleation as the only treatment option.

Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series

Dermatology ◽  
2013 ◽  
Vol 226 (4) ◽  
pp. 358-361 ◽  
Author(s):  
Giacomo Caldarola ◽  
Luca Fania ◽  
Barbara Fossati ◽  
Anna Zampetti ◽  
Paolo Broganelli ◽  
...  
Keyword(s):  
Case Series ◽  
Oculocutaneous Albinism ◽  
Melanocytic Lesions

scholarly journals Bilateral Diffuse Uveal Melanocytic Proliferation Presenting as Small Choroidal Melanoma

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
J. N. Ulrich ◽  
S. Garg ◽  
G. K. Escaravage ◽  
T. M. Meredith
Keyword(s):  
Visual Acuity ◽  
Clinical Picture ◽  
Clinical Case ◽  
Radioactive Iodine ◽  
Palliative Chemotherapy ◽  
Choroidal Melanoma ◽  
Orange Pigment ◽  
History Of ◽  
Choroidal Nevus ◽  
The Right

Purpose. To describe a patient with Bilateral Diffuse Uveal Proliferation who presented initially with a clinical picture consistent with choroidal melanoma.Methods. Presentation of a clinical case with fundus photos, fluorescein angiography, and optical coherence tomography.Results. A 70-year-old Caucasian male with history of esophageal cancer presented with an asymptomatic pigmented choroidal lesion in his left eye initially diagnosed as choroidal nevus. This lesion enlarged over the course of a year and developed orange pigment and increased thickness. A metastatic workup was negative, and a radioactive iodine plaque was placed on the left eye. Over the next six months, the visual acuity in his left eye decreased. His clinical picture was consistent with unilateral Diffuse Uveal Proliferation. A recurrence of his esophageal carcinoma with metastasis was discovered and palliative chemotherapy was initiated. Although his visual acuity improved in the left eye, similar pigmentary changes developed in the right fundus. His visual acuity in both eyes gradually decreased to 20/200 until his death a year later.Conclusion. BDUMP should always be considered in the differential diagnosis of patients with pigmented fundus lesions and a history of nonocular tumors.

scholarly journals Choroidal Melanoma: Our Experience

2019 ◽  
Vol 11 (1) ◽  
pp. 64-73
Author(s):  
Diwa Hamal ◽  
Ben Limbu ◽  
Purnima Rajkarnikar Sthapit ◽  
Eli Pradhan ◽  
Reshmi Shrestha ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Histopathological Examination ◽  
External Beam Radiotherapy ◽  
Choroidal Melanoma ◽  
Case Series ◽  
Vitreous Hemorrhage ◽  
Lesion Size ◽  
Epitheloid Cell ◽  
Prospective Case Series ◽  
Brachy Therapy

Background: Choroidal melanomas are diagnosed in approximately 6 out of one million Americans per year, and although their incidence is low, they are the most common primary intraocular tumor in adults. Methods: Choroidal melanoma is rare tumors and till date no such reports with sclera involvement has been reported from Nepal. It is a prospective case series. The aim of this study is for awareness of the severity of the Choroidal melanoma and it’s management. Besides, it is also to study the demography, presentation, histopathological variations and management of cases of choroidal melanoma. All the consecutive cases of Choroidal melanoma presenting between Jan 2017 to May 2018 and those who were within the inclusion criteria were included in this study. Results: There were eight patients, five male and three female, within age range of 18-73, median age was 47. All patients presented with decreased vision ranging from 6/24 to PL of less then three months to 2 years duration. Fund us showed choroidal mass associated with Vitreous hemorrhage (VH), and retinal detachment (RD). Two patients were managed with enucleation with External beam radiotherapy (EBRT). Four underwent only enucleation. One patient with lesion size less then 10mm under went plaque brachy therapy. One patient underwent initially Plaque brachy therapy but later had to undergo Enucleation. Histopathological examination (HPE) of enucleated patient revealed epitheloid cell melanoma grade three in four and Spindle cell melanoma in three patients. Each one patient of epitheloid cell melanoma and spindle cell melanomahad scleral involvement. Indication for radiotherapy was scleral involvement. Conclusion: With 8 cases of Choroidal melanoma in a single year in a single hospitalgives us a clue that there may be much more undiagnosed cases of Choroidal melanomain Nepal that should be taken seriously. Going for annual eye examination with routine dilated fund us exams can help in prevention and early diagnosis of this life and sight threatening condition and to reduce the mortality rate.

scholarly journals Pediatric giant cell glioblastoma: a rare entity

2017 ◽  
Vol 4 (3) ◽  
pp. 1098
Author(s):  
Poornima Vijayan ◽  
Zuhara Shemin ◽  
Sharmina Saleem ◽  
Anupama Ponniah
Keyword(s):  
Giant Cell ◽  
Histopathological Examination ◽  
Case Reports ◽  
Case Series ◽  
High Grade Glioma ◽  
Molecular Characteristics ◽  
Recent Onset ◽  
Pediatric Age Group ◽  
The Right ◽  
Giant Cell Glioblastoma

Giant cell glioblastoma (GCG) is a rare subtype of glioblastoma multiforme (GBM) which represents 0.8% of all brain tumors and 5% of glioblastomas. This entity is all the more rarer in the pediatric age group. And, due to the limited number of case reports and case series in literature, its epidemiology, natural history and follow up are not well documented. We present this case for its rarity. A 14-year-old girl presented with history of recent onset headache and vomiting from last 10 days. Magnetic resonance imaging (MRI) brain revealed a mass lesion in the right temporo-parietal region, suggestive of a high-grade glioma. Histopathological examination revealed features typical of giant cell glioblastoma. Giant cell glioblastoma, is an extremely rare variant of gliobastoma multiforme, merits special mention because it has been hypothesized to be associated with a longer survival compared with GBM in both adults and children, possibly because of the younger age at presentation, certain histopathological and molecular characteristics of this entity.

scholarly journals A Case Series of Atrial Myxomas – A Tertiary Care Centre Experience

2021 ◽  
pp. 417-424
Author(s):  
Dhanya Menon ◽  
P. S. Muthusubramanian ◽  
Sonti Sulochana ◽  
S. Chitra ◽  
K. Meenakshi
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Recurrent Stroke ◽  
Tertiary Care ◽  
Cardiac Myxoma ◽  
Case Series ◽  
Tertiary Care Centre ◽  
Histopathological Correlation ◽  
One Year ◽  
The Right

Aim: The current study aims at highlighting the clinical presentation, echocardiographic profile and histopathological details of the four cases of cardiac myxoma which we had encountered in our institution within a period of one year and to identify a relationship between the clinical behaviour and the histopathological picture. Results: Among the four cases 2 were males and 2 were females and their ages ranged from 36 to 49 years. Two of the four patients presented with chest pain and palpitations , one with dyspnoea and the other case presented with recurrent stroke. Three of the cases were located in the left atrium while one case was in the right atrium. The histopathological examination of all the cases showed stellate , round and polygonal cells surrounded by abundant myxoid stroma. There was no histopathological correlation between the different clinical presentations or locations of the myxomas. Conclusion: Although histopathological examination is necessary along with echocardiography to make a diagnosis of cardiac myxoma , there is no correlation between the different clinical presentation , site and the histopathological examination.

Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Gruber-Szydlo ◽  
Poreba ◽  
Belowska-Bien ◽  
Derkacz ◽  
Badowski ◽  
...  
Keyword(s):  
Case Report ◽  
Magnetic Resonance Angiography ◽  
Popliteal Artery ◽  
Doppler Ultrasonography ◽  
Histopathological Examination ◽  
Previous History ◽  
Plain Radiography ◽  
Artery Thrombosis ◽  
History Of ◽  
The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Debarati Paul ◽  
Suman Saha ◽  
Neelam Singh ◽  
Jayansgu Sengupta ◽  
Santi M. Mandal
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Candida Albicans ◽  
Histopathological Examination ◽  
Specific Interaction ◽  
Major Threat ◽  
Effective Combination ◽  
Male Farmer ◽  
Successful Control ◽  
The Right ◽  
Corneal Button

Introduction: Nowadays, co-infection by interspecific organisms is major threat in infection control. To identify the effective combination of drugs to control the keratitis caused by Candida albicans with Pseudomonas aeruginosa are attributed in this study. Materilas and Methods: The patient of a 47 years old male farmer with infection in the right eye which showed redness and watering was treated with fortified cefazolin and fortified tobramycin before referral. No pigmentation or vascularisation was noted. The excised corneal button was also subjected to microbiological and histopathological examination. Results: A rare case of keratitis caused by co-infection of Candida albicans with Pseudomonas aeruginosa was identified. Results confirmed the inter-specific interaction of the two microorganisms. Conclusion: Cases of co-infection by Candida and Pseudomonas are not abundantly reported and difficult to treat. In this case, treatment involved Amphotercin-B and ciprofloxacin, effectively eradicated the infection. This therapy may be successfully implied for such cases of co-infection in future.

Diverticulization Duodenal Distal Technique for Injury Angle Duodenojejunal

2016 ◽  
Vol 3 (1) ◽  
pp. 265-268
Author(s):  
Luis R. Martinez ◽  
Pablo Valsangiacomo ◽  
Gabriela Espinosa ◽  
Gabriela Wagner ◽  
Roberto Taruselli
Keyword(s):  
Case Series ◽  
Average Hospital ◽  
Single Anastomosis ◽  
Observational Technique ◽  
Mortality Case ◽  
Management Techniques ◽  
The Right ◽  
Serious Injuries ◽  
Suture Failure ◽  
Initial Results

Duodenojejunal injuries region at the angle of Treitz are rare, variable etiology and often associated with other serious injuries. In trauma situations with perforations and bleeding, his approach is often difficult. The primary suture, resection / anastomosis and duodenal exclusion are the usual for trauma management techniques in this region. The aim of this paper is to show the initial results of an alternative for injuries duodenojejunal angle (IDJA) by filling a retrospective, descriptive and observational technique, 12 patients operated were analyzed over a period of 15 years, carriers IDJA, age: 34, 11 gunshot wound. 92% of the cases had other associated visceral injuries. The average for the ISS was 29. In all cases located in duodenum duodenojejunoanastomosis II, via the right lateromesenterica upon closing section and duodenum level III was performed. 58% of cases were complicated. Mortality case series were 1 (8%) digestive suture failure colon. Average Hospital stay 26 days. Conclusion: A simple, safe and maintaining gut physiology is proposed technique; with a single anastomosis, located in well-vascularized area and away from bruising and contaminated areas. The complications were pancreatic fistula and digestive suture failure.

Biochemical and Histopathological Evaluation of the Radioprotective Effects of Melatonin Against Gamma Ray-Induced Skin Damage

2019 ◽  
Vol 12 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Dheyauldeen Shabeeb ◽  
Masoud Najafi ◽  
Ahmed Eleojo Musa ◽  
Mansoor Keshavarz ◽  
Alireza Shirazi ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Histopathological Examination ◽  
Radical Scavenging ◽  
Limiting Factor ◽  
Skin Damage ◽  
Exposed Skin ◽  
Male Wistar Rats ◽  
Time Periods ◽  
Skin Damages ◽  
The Right

Background:Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. To ameliorate this complication, we used melatonin as a radioprotective agent due to its antioxidant and anti-inflammatory effects, free radical scavenging, improving overall survival after irradiation as well as minimizing the degree of DNA damage and frequency of chromosomal abrasions.Methods:Sixty male Wistar rats were randomly assigned to 4 groups: control (C), melatonin (M), radiation (R) and melatonin + radiation (MR). A single dose of 30 Gy gamma radiation was exposed to the right hind legs of the rats while 40 mg/ml of melatonin was administered 30 minutes before irradiation and 2 mg/ml once daily in the afternoon for one month till the date of rat’s sacrifice. Five rats from each group were sacrificed 4, 12 and 20 weeks after irradiation. Afterwards, their exposed skin tissues were examined histologically and biochemically.Results:In biochemical analysis, we found that malondialdehyde (MDA) levels significantly increased in R group and decreased significantly in M and MR groups after 4, 12, and 20 weeks, whereas catalase (CAT) and superoxide dismutase (SOD) activities decreased in the R group and increased in M and MR groups during the same time periods compared with the C group (p<0.05). Histopathological examination found there were statistically significant differences between R group compared with the C and M groups for the three different time periods (p<0.005, p<0.004 and p<0.004) respectively, while R group differed significantly with MR group (p<0.013). No significant differences were observed between C and M compared with MR group (p>0.05) at 4 and 20 weeks except for inflammation and hair follicle atrophy, while there were significant effects at 12 weeks (p<0.05).Conclusion:Melatonin can be successfully used for the prevention and treatment of radiation-induced skin injury. We recommend the use of melatonin in optimal and safe doses. These doses should be administered over a long period of time for effective radioprotection and amelioration of skin damages as well as improving the therapeutic ratio of radiotherapy.

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