scholarly journals Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor κB Axis in Macrophages and Mice Lungs

Pathobiology ◽  
2019 ◽  
Vol 86 (5-6) ◽  
pp. 237-247 ◽  
Author(s):  
Nan Ma ◽  
Ting-Ting Deng ◽  
Qin Wang ◽  
Zhou-Ling Luo ◽  
Cai-Feng Zhu ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Nuclear Factor Κb ◽  
Mediator Release ◽  
Sirtuin 1 ◽  
Nuclear Factor ◽  
Proinflammatory Mediator

Activation of nuclear factor-κB and its proinflammatory mediator cascade in the infarcted rat heart

2004 ◽  
Vol 321 (4) ◽  
pp. 879-885 ◽  
Author(s):  
Li Lu ◽  
Sue S. Chen ◽  
John Q. Zhang ◽  
Felix J. Ramires ◽  
Yao Sun
Keyword(s):  
Rat Heart ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Proinflammatory Mediator

scholarly journals Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells

2015 ◽  
Vol 77 (12) ◽  
pp. 1681-1684 ◽  
Author(s):  
Shingo ISHIKAWA ◽  
Hiroshi TAKEMITSU ◽  
Makoto HABARA ◽  
Nobuko MORI ◽  
Ichiro YAMAMOTO ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Nuclear Factor Κb ◽  
Cytokine Expression ◽  
Sirtuin 1 ◽  
Fibroblast Cells ◽  
Nuclear Factor

Cigarette Smoke–Induced Damage-Associated Molecular Pattern Release from Necrotic Neutrophils Triggers Proinflammatory Mediator Release

2015 ◽  
Vol 52 (5) ◽  
pp. 554-562 ◽  
Author(s):  
Irene H. Heijink ◽  
Simon D. Pouwels ◽  
Carin Leijendekker ◽  
Harold G. de Bruin ◽  
G. Jan Zijlstra ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Mediator Release ◽  
Proinflammatory Mediator ◽  
Molecular Pattern

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging

2007 ◽  
Vol 292 (2) ◽  
pp. L567-L576 ◽  
Author(s):  
Se-Ran Yang ◽  
Jessica Wright ◽  
Mark Bauter ◽  
Kathryn Seweryniak ◽  
Aruna Kode ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Proinflammatory Cytokine ◽  
Inflammatory Cells ◽  
Mediator Release ◽  
Cytokine Release ◽  
Class Iii ◽  
Proinflammatory Mediator ◽  
Proinflammatory Mediators ◽  
Rat Lungs

The silent information regulator 2 (Sir2) family of proteins (sirtuins or SIRTs), which belong to class III histone/protein deacetylases, have been implicated in calorie restriction, aging, and inflammation. We hypothesized that cigarette smoke-mediated proinflammatory cytokine release is regulated by SIRT1 by its interaction with NF-κB in a monocyte-macrophage cell line (MonoMac6) and in inflammatory cells of rat lungs. Cigarette smoke extract (CSE) exposure to MonoMac6 cells caused dose- and time-dependent decreases in SIRT1 activity and levels, which was concomitant to increased NF-κB-dependent proinflammatory mediator release. Similar decrements in SIRT1 were also observed in inflammatory cells in the lungs of rats exposed to cigarette smoke as well as with increased levels of several NF-κB-dependent proinflammatory mediators in bronchoalveolar lavage fluid and in lungs. Sirtinol, an inhibitor of SIRT1, augmented, whereas resveratrol, an activator of SIRT1, inhibited CSE-mediated proinflammatory cytokine release. CSE-mediated inhibition of SIRT1 was associated with increased NF-κB levels. Furthermore, we showed that SIRT1 interacts with the RelA/p65 subunit of NF-κB, which was disrupted by cigarette smoke, leading to increased acetylation RelA/p65 in MonoMac6 cells. Thus our data show that SIRT1 regulates cigarette smoke-mediated proinflammatory mediator release via NF-κB, implicating a role of SIRT1 in sustained inflammation and aging of the lungs.

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