scholarly journals Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis

2019 ◽  
Vol 180 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Phillip R. Purnell ◽  
Benjamin L. Addicks ◽  
Habib G. Zalzal ◽  
Scott Shapiro ◽  
Sijin Wen ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Chronic Rhinosinusitis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Chemosensory Pathway

Association of Single-Nucleotide Polymorphisms With Chronic Rhinosinusitis in a Southwestern Han Chinese Population: A Replication Study

2019 ◽  
Vol 34 (3) ◽  
pp. 352-360
Author(s):  
Yang Xu ◽  
Yongbo Zheng ◽  
Min Cao ◽  
Wen Yang ◽  
Jianjun Ren ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Chronic Rhinosinusitis ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Chinese Populations ◽  
Genotypic Association ◽  
Sinonasal Outcome Test

Background Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease. The role of genetic variations of related genes in the development of CRS and severity of symptoms is unknown in Southwestern Chinese populations. Objective We selected candidate CRS-related genetic polymorphisms and evaluated the associations that were different according to the presence of nasal polyp, asthma, and allergic rhinitis (AR) in a Southwestern Chinese population. Detailed phenotypes were compared among different genotypes. Methods In 452 CRS patients and 591 healthy controls, clinico-epidemiological information was collected and 23 previously reported CRS-related single-nucleotide polymorphisms (SNPs) were genotyped. Genotypes were determined using a Sequenom MassARRAY SNP genotyping system. Clinical disease measures including the sinonasal outcome test, visual analogue scale (VAS), and symptom severity VAS were evaluated for each patient. The association between CRS, genotypes, asthma, AR, and symptoms was analyzed. The effect of sex, age, body mass index, and status of smoking was considered. Results Statistically significant genotypic association with CRS was observed with an IL1RL1 genetic polymorphism (rs13431828; odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.06–1.99; P = .02). Similar association was observed with rs13431828 in subgroups of CRS with nasal polyps (OR = 1.53; 95% CI, 1.03–2.29; P = .04), asthma (OR = 2.08; 95% CI, 1.14–3.79; P = .02), and AR (OR = 1.59; 95% CI, 1.06–2.39; P = .02). No significant association with other SNPs was observed. The evaluated genetic polymorphisms were not associated with clinical symptom scores. Conclusion This study replicated rs13431828 as being associated with CRS in Southwestern Chinese. rs13431828 was also significantly associated with CRS patients who have concurrent allergic nasal diseases.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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