Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions

Digestion ◽  
2019 ◽  
Vol 101 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Ichiro Otani ◽  
Shiro Oka ◽  
Shinji Tanaka ◽  
Sumio Iio ◽  
Akiyoshi Tsuboi ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

scholarly journals Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2240
Author(s):  
Soo-Young Na ◽  
Yun-Jeong Lim
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Postoperative Recurrence ◽  
Treat To Target ◽  
Diagnostic Modality ◽  
Colon Capsule Endoscopy ◽  
Bowel Diseases ◽  
Colon Capsule ◽  
The Cost

Capsule endoscopy (CE) has proven to be a valuable diagnostic modality for small bowel diseases over the past 20 years, particularly Crohn’s disease (CD), which can affect the entire gastrointestinal tract from the mouth to the anus. CE is not only used for the diagnosis of patients with suspected small bowel CD, but can also be used to assess disease activity, treat-to-target, and postoperative recurrence in patients with established small bowel CD. As CE can detect even mildly non-specific small bowel lesions, a high diagnostic yield is not necessarily indicative of high diagnostic accuracy. Moreover, the cost effectiveness of CE as a third diagnostic test employed usually after ileocolonoscopy and MR or CT enterography is an important consideration. Recently, new developments in colon capsule endoscopy (CCE) have increased the utility of CE in patients with ulcerative colitis (UC) and pan-enteric CD. Although deflation of the colon during the examination and the inability to evaluate dysplasia-associated lesion or mass results in an inherent risk of overestimation or underestimation, the convenience of CCE examination and the risk of flare-up after colonoscopy suggest that CCE could be used more actively in patients with UC.

scholarly journals Colon Capsule Endoscopy vs. CT Colonography Following Incomplete Colonoscopy: A Systematic Review with Meta-Analysis

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3367
Author(s):  
Ulrik Deding ◽  
Lasse Kaalby ◽  
Henrik Bøggild ◽  
Eva Plantener ◽  
Mie Kruse Wollesen ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Meta Analysis ◽  
Rate Sensitivity ◽  
Completion Rate ◽  
Polyp Detection ◽  
Proximal Point ◽  
Incomplete Colonoscopy ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

Following incomplete colonoscopy (IC) patients often undergo computed tomography colonography (CTC), but colon capsule endoscopy (CCE) may be an alternative. We compared the completion rate, sensitivity and diagnostic yield for polyp detection from CCE and CTC following IC. A systematic literature search resulted in twenty-six studies. Extracted data included inter alia, complete/incomplete investigations and polyp findings. Pooled estimates of completion rates of CCE and CTC and complete colonic view rates (CCE reaching the most proximal point of IC) of CCE were calculated. Per patient diagnostic yields of CCE and CTC were calculated stratified by polyp sizes. CCE completion rate and complete colonic view rate were 76% (CI 95% 68–84%) and 90% (CI 95% 83–95%). CTC completion rate was 98% (CI 95% 96–100%). Diagnostic yields of CTC and CCE were 10% (CI 95% 7–15%) and 37% (CI 95% 30–43%) for any size, 13% (CI 95% 9–18%) and 21% (CI 95% 12–32%) for >5-mm and 4% (CI 95% 2–7%) and 9% (CI 95% 3–17%) for >9-mm polyps. No study performed a reference standard follow-up after CCE/CTC in individuals without findings, rendering sensitivity calculations unfeasible. The increased diagnostic yield of CCE could outweigh its slightly lower complete colonic view rate compared to the superior CTC completion rate. Hence, CCE following IC appears feasible for an introduction to clinical practice. Therefore, randomized studies investigating CCE and/or CTC following incomplete colonoscopy with a golden standard reference for the entire population enabling estimates for sensitivity and specificity are needed.

scholarly journals Diagnostic yield of colon capsule endoscopy for Crohn’s disease lesions in the whole gastrointestinal tract

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Keisaku Yamada ◽  
Masanao Nakamura ◽  
Takeshi Yamamura ◽  
Keiko Maeda ◽  
Tsunaki Sawada ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Large Bowel ◽  
Diagnostic Yield ◽  
Gi Tract ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule ◽  
Bowel Segments

Abstract Background Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown. Aim To elucidate the diagnostic yield of PCCE-2 in patients with CD. Methods Patients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard. Results Of the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively. Conclusion PCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.

scholarly journals Diagnostic Yield of Colon Capsule Endoscopy for Crohn’s Disease Lesions in the Whole Gastrointestinal Tract

2020 ◽  
Author(s):  
Keisaku Yamada ◽  
Masanao Nakamura ◽  
Takeshi Yamamura ◽  
Keiko Maeda ◽  
Tsunaki Sawada ◽  
...  
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Large Bowel ◽  
Diagnostic Yield ◽  
Clinical Settings ◽  
Gi Tract ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule ◽  
Bowel Segments ◽  
Upper Gastrointestinal

Abstract BACKGROUNDCrohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables to observe the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown. AIMTo elucidate the diagnostic yield of PCCE-2 in patients with CD.METHODSPatients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard.RESULTSOf the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively.CONCLUSIONPCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.

scholarly journals Diagnostic Yields and Clinical Impacts of Capsule Endoscopy

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1842
Author(s):  
Seung Min Hong ◽  
Sung Hoon Jung ◽  
Dong Hoon Baek
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Critical Role ◽  
Current Status ◽  
Entire Small Bowel ◽  
Colon Capsule Endoscopy ◽  
Bowel Diseases ◽  
Colon Capsule ◽  
Bowel Disorders

Observing the entire small bowel is difficult due to the presence of complex loops and a long length. Capsule endoscopy (CE) provides a noninvasive and patient-friendly method for visualizing the small bowel and colon. Small bowel capsule endoscopy (SBCE) has a critical role in the diagnosis of small bowel disorders through the direct observation of the entire small bowel mucosa and is becoming the primary diagnostic tool for small bowel diseases. Recently, colon capsule endoscopy (CCE) was also considered safe and feasible for obtaining sufficient colonic images in patients with incomplete colonoscopy, in the absence of bowel obstruction. This review article assesses the current status of CE in terms of the diagnostic yield and the clinical impact of SBCE in patients with obscure gastrointestinal bleeding, who have known or suspected Crohn’s disease, small bowel tumor and inherited polyposis syndrome, celiac disease, and those who have undergone CCE.

scholarly journals Evaluation of Performance in Colon Capsule Endoscopy Reading by Endoscopy Nurses

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yukiko Handa ◽  
Konosuke Nakaji ◽  
Kayo Hyogo ◽  
Makiko Kawakami ◽  
Tomomi Yamamoto ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Detection Rate ◽  
Reading Time ◽  
Diagnostic Yield ◽  
Detection Rates ◽  
Colon Capsule Endoscopy ◽  
Significant Difference ◽  
Novice Nurses ◽  
Colon Capsule ◽  
Clinically Significant

Background. Although there are papers reporting on the accuracy of colon capsule endoscopy (CCE) compared with colonoscopy (CS), there are few reports on the detection rates of significant lesions by endoscopy nurses. We previously reported no significant difference in the detection rates for small bowel capsule endoscopy (SBCE) images among two well-trained physicians and one expert nurse. Objective. To evaluate the reading time and detection rate of the significant lesions of CCE images among novice and trained expert endoscopy nurses and novice physicians. Methods. CCE videos of 20 consecutive patients who performed both CCE and CS with clinically significant localized lesions were selected. Two trained expert endoscopy nurses, untrained two novice physicians, and novice three endoscopy nurses reviewed CCE videos. The detection rate of the lesions and reading time were compared among the three groups and were evaluated by comparison between the first and the second 10 videos. Results. The median reading time was the shortest (19 min) in the trained expert endoscopy nurses and the longest (45 min) in the novice nurses. The number of thumbnails tended to be more in the trained expert endoscopy nurses in the first 10-video reading. Although the detection rates of small polyps (<5 mm) were significantly lower (46.5%, p = 0.025 ) in the novice nurses compared to the others, they were improved (35.2% to 63.5%, p = 0.015 ) in the second 10 videos. The detection rates of tumor lesions by either one of two trained expert endoscopy nurses were higher compared to those by each novice physician. Conclusions. The trained expert endoscopy nurses for CCE reading can reduce physician's time and improve the diagnostic yield.

scholarly journals Scoring Systems for Clinical Colon Capsule Endoscopy—All You Need to Know

2021 ◽  
Vol 10 (11) ◽  
pp. 2372
Author(s):  
Trevor Tabone ◽  
Anastasios Koulaouzidis ◽  
Pierre Ellul
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Colonic Polyps ◽  
Scoring Systems ◽  
Conventional Colonoscopy ◽  
Suitable Alternative ◽  
Specific Patient ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule ◽  
Event Rates

In the constantly developing era of minimal diagnostic invasiveness, the role of colon capsule endoscopy in colonic examination is being increasingly recognised, especially in the context of curtailed endoscopy services due to the COVID-19 pandemic. It is a safe diagnostic tool with low adverse event rates. As with other endoscopic modalities, various colon capsule endoscopy scores allow the standardisation of reporting and reproducibility. As bowel cleanliness affects CCE’s diagnostic yield, a few operator-dependent scores (Leighton–Rex and CC-CLEAR scores) and a computer-dependent score (CAC score) have been developed to grade bowel cleanliness objectively. CCE can be used to monitor IBD mucosal disease activity through the UCEIS and the panenteric CECDAIic score for UC and CD, respectively. CCE may also have a role in CRC screening, given similar sensitivity and specificity rates to conventional colonoscopy to detect colonic polyps ≥ 10 mm and CRC. Given CCE’s diagnostic yield and reproducible clinical scores with high inter-observer agreements, CCE is fast becoming a suitable alternative to conventional colonoscopy in specific patient populations.

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