Urinary Nephrin as a Biomarker of Glomerular Maturation and Injury Is Associated with Acute Kidney Injury and Mortality in Critically Ill Neonates

Neonatology ◽  
2019 ◽  
Vol 116 (1) ◽  
pp. 58-66
Author(s):  
Jiao Chen ◽  
Gen Li ◽  
Sanfeng Wang ◽  
Xiaohan Hu ◽  
Yunqing Sun ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Kidney Injury ◽  
Critically Ill Neonates

Plasma cystatin C versus renal resistive index as early predictors of acute kidney injury in critically ill neonates

2020 ◽  
Vol 16 (2) ◽  
pp. 206.e1-206.e8
Author(s):  
Akram E. El-sadek ◽  
Mohamed A. El-Gamasy ◽  
Eman G. Behiry ◽  
Ahmed A. Torky ◽  
Mohamed A. Fathy
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Cystatin C ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Resistive Index ◽  
Early Predictors ◽  
Critically Ill Neonates

Kidney injury molecule-1/creatinine as a urinary biomarker of acute kidney injury in critically ill neonates

2020 ◽  
Vol 16 (5) ◽  
pp. 688.e1-688.e9
Author(s):  
Akram E. ElSadek ◽  
Elham Abd El gafar ◽  
Eman G. Behiry ◽  
Siham A. Nazem ◽  
Omima M. Abdel haie
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Kidney Injury ◽  
Urinary Biomarker ◽  
Critically Ill Neonates ◽  
Kidney Injury Molecule 1

scholarly journals A novel urinary biomarker profile to identify acute kidney injury (AKI) in critically ill neonates: a pilot study

2013 ◽  
Vol 28 (11) ◽  
pp. 2179-2188 ◽  
Author(s):  
Suma Bhat Hoffman ◽  
An N. Massaro ◽  
Ángel A. Soler-García ◽  
Sofia Perazzo ◽  
Patricio E. Ray
Keyword(s):  
Acute Kidney Injury ◽  
Pilot Study ◽  
Critically Ill ◽  
Kidney Injury ◽  
Urinary Biomarker ◽  
Critically Ill Neonates

scholarly journals Incidence and risk factors of acute kidney injury among the critically ill neonates

2015 ◽  
Vol 26 (3) ◽  
pp. 549 ◽  
Author(s):  
Samuel Makar ◽  
Abdel-RahmanA Abdel-Razek ◽  
Dalia Abd Elaziz ◽  
AymanA El-Badawy
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Critically Ill ◽  
Kidney Injury ◽  
Critically Ill Neonates

scholarly journals Impact of Acute Kidney Injury on Critically Ill Children and Neonates

2021 ◽  
Vol 9 ◽  
Author(s):  
Bassil Leghrouz ◽  
Ahmad Kaddourah
Keyword(s):  
Acute Kidney Injury ◽  
Intensive Care ◽  
Critically Ill ◽  
Pediatric Patients ◽  
Kidney Injury ◽  
Pediatric Intensive Care ◽  
Clinical Syndrome ◽  
Morbidity And Mortality ◽  
Critically Ill Children ◽  
Critically Ill Neonates

Acute kidney injury (AKI) is a clinical syndrome that manifests as an abrupt impairment of kidney function. AKI is common in critically ill pediatric patients admitted to the pediatric intensive care units. AKI is a deleterious complication in critically ill children as it is associated with increased morbidity and mortality. This review provides an overview of the incidence, morbidity, and mortality of AKI in critically ill children in general and specific cohorts such as post-cardiac surgeries, sepsis, critically ill neonates, and post stem cell transplantation.

Acute Peritoneal Dialysis System for Neonates with Acute Kidney Injury Requiring Renal Replacement Therapy: A Case Series

2018 ◽  
Vol 38 (2_suppl) ◽  
pp. 45-52 ◽  
Author(s):  
Xiang Ao ◽  
Yong Zhong ◽  
Xiao-he Yu ◽  
Mark R. Marshall ◽  
Tao Feng ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Peritoneal Dialysis ◽  
Critically Ill ◽  
Case Series ◽  
Kidney Injury ◽  
Venous Catheter ◽  
Seldinger Technique ◽  
The Novel ◽  
Exit Site Infection ◽  
Critically Ill Neonates

Background Acute kidney injury (AKI) is common in critically ill neonates, and peritoneal dialysis (PD) can be a lifesaving option. In China, however, much of the equipment for PD in neonates is not available. We describe results with a novel system for PD, which has been developed locally to improve access to therapy and care for critically ill neonates requiring PD in China. Methods The system comprises a 14-gauge single-lumen central venous catheter serving as a PD catheter, inserted by Seldinger technique, with an adapted twin bag PD system. Ten neonates with AKI were treated using the novel PD system. Results The 10 patients ranged in age from 1 day to 22 days, with bodyweights between 700 g and 3,300 g. Average time to renal function recovery was between 14 and 96 hours. Complications related to the novel PD system included leak ( n = 1), catheter displacement ( n = 1), and catheter obstruction ( n = 1). There were no complications related to insertion, no cases of peritonitis or exit-site infection, and no subsequent hernias. A comparison of costs indicated that the novel PD system is less expensive than conventional systems involving open insertion of Tenckhoff catheters. Conclusions Peritoneal dialysis using the novel PD system is simple, safe, and effective for suitable neonates with AKI in China.

scholarly journals Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study

Critical Care ◽  
2013 ◽  
Vol 17 (4) ◽  
pp. R151 ◽  
Author(s):  
Alexandra JM Zwiers ◽  
Saskia N de Wildt ◽  
Wim CJ Hop ◽  
Eiske M Dorresteijn ◽  
Saskia J Gischler ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cohort Study ◽  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Kidney Injury ◽  
Frequent Complication ◽  
Membrane Oxygenation ◽  
Critically Ill Neonates

scholarly journals Risk Factors for Acute Kidney Injury in Critically Ill Neonates: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Qian Hu ◽  
Shao-Jun Li ◽  
Qian-Ling Chen ◽  
Han Chen ◽  
Qiu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Acute Kidney Injury ◽  
Critically Ill ◽  
Apgar Score ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Cochrane Library ◽  
Increased Risk ◽  
Critically Ill Neonates

Background and Objective: Acute kidney injury (AKI) is recognized as an independent risk factor for mortality and long-term poor prognosis in neonates. The objective of the study was to identify the risk factors for AKI in critically ill neonates to provide an important basis for follow-up research studies and early prevention.Methods: The PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WanFang Med, SinoMed, and VIP Data were searched for studies of risk factors in critically ill neonates. Studies published from the initiation of the database to November 19, 2020, were included. The quality of studies was assessed by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality (AHRQ) checklist. The meta-analysis was conducted with Stata 15 and drafted according to the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement.Results: Seventeen studies (five cohort studies, ten case-control studies, and two cross-sectional studies) were included in meta-analysis, with 1,627 cases in the case group and 5,220 cases in the control group. The incidence of AKI fluctuated from 8.4 to 63.3%. Fifteen risk factors were included, nine of which were significantly associated with an increased risk of AKI in critically ill neonates: gestational age [standardized mean difference (SMD) = −0.31, 95%CI = (−0.51, −0.12), P = 0.002], birthweight [SMD = −0.37, 95%CI = (−0.67, −0.07), P = 0.015], 1-min Apgar score [SMD = −0.61, 95%CI = (−0.78, −0.43), P = 0.000], 5-min Apgar score [SMD = −0.71, 95%CI = (−1.00, −0.41), P = 0.000], congenital heart disease (CHD) [odds ratio (OR) = 2.94, 95%CI = (2.08, 4.15), P = 0.000], hyperbilirubinemia [OR = 2.26, 95%CI = (1.40, 3.65), P = 0.001], necrotizing enterocolitis (NEC) [OR = 6.32, 95%CI = (2.98, 13.42), P = 0.000], sepsis [OR = 2.21, 95%CI = (1.25, 3.89), P = 0.006], and mechanical ventilation [OR = 2.37, 95%CI = (1.50, 3.75), P = 0.000]. Six of them were not significantly associated with AKI in critically ill neonates: age [SMD = −0.25, 95%CI = (−0.54, 0.04), P = 0.095], male sex [OR = 1.10, 95%CI =(0.97, 1.24), P = 0.147], prematurity [OR = 0.90, 95%CI(0.52, 1.56), P = 0.716], cesarean section [OR = 1.52, 95%CI(0.77, 3.01), P = 0.234], prenatal hemorrhage [OR = 1.41, 95%CI = (0.86, 2.33), P = 0.171], and vancomycin [OR = 1.16, 95%CI = (0.71, 1.89), P = 0.555].Conclusions: This meta-analysis provides a preliminary exploration of risk factors in critically ill neonatal AKI, which may be useful for the prediction of AKI.Systematic Review Registration: PROSPERO (CRD42020188032).

scholarly journals Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.

GEGET ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 60-70
Author(s):  
Wesam Afifi ◽  
Taghreed Oneam ◽  
Osama Elfekky ◽  
Waleed Abdelhalim ◽  
Effat Assar
Keyword(s):  
Acute Kidney Injury ◽  
Body Weight ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Cystatin C ◽  
Kidney Injury ◽  
Early Prediction ◽  
Critically Ill Neonates
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