scholarly journals Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris

2019 ◽  
Vol 11 (1) ◽  
pp. 82-85 ◽  
Author(s):  
Makiko Yajima ◽  
Tomoko Akeda ◽  
Makoto Kondo ◽  
Koji Habe ◽  
Keiichi Yamanaka
Keyword(s):  
Hair Follicle ◽  
Psoriasis Vulgaris ◽  
Skin Diseases ◽  
Interleukin 17 ◽  
Th1 Cells ◽  
T Helper ◽  
Immune Mediated ◽  
Th 17 ◽  
Chronic Skin ◽  
Chronic Skin Diseases

We report two cases of alopecia diffusa during the treatment of psoriasis vulgaris with interleukin (IL)-17 inhibitors. Psoriasis is one of the most common immune-mediated chronic skin diseases, strongly associated with IL-17A. Clinically, the monoclonal antibodies to IL-17A or its receptor, IL-17R, show a dramatic effect against psoriasis. Alopecia is also an IL-17-mediated autoimmune disease, and IL-17 inhibitors have been expected to be the gold standard for the treatment of alopecia; therefore, the complication of alopecia while using IL-17 may be regarded as an unexpected “paradoxical reaction.” T helper (Th)17 cells are not cytotoxic enough by themselves to undermine the hair follicle under normal circumstances, they need the coexistence of CD8+ cytotoxic Th1 cells. Th17 cells may be the initiator of the damage of the hair follicle, but CD8 T cells or more powerful Th1 cells are required as followers. The Th17/Th1 axis might convert into a Th1-dominant immune status using IL-17 inhibitors, and the destruction of the hair follicle might result in alopecia. An accumulation of cases is to be expected.

The Constructive Thinking Inventory: Factorial Structure in Healthy Individuals and Patients with Chronic Skin Diseases

1998 ◽  
Vol 14 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Jürgen Hoyer ◽  
Mechthild Averbeck ◽  
Thomas Heidenreich ◽  
Ulrich Stangier ◽  
Karin Pöhlmann ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Principal Component ◽  
Initial Study ◽  
Statistical Independence ◽  
Constructive Thinking ◽  
Global Factor ◽  
Emotional Coping ◽  
Factor Congruence ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Epstein's “Constructive Thinking Inventory” (CTI) was developed to measure the construct of experiential intelligence, which is based on his cognitive-experiential self-theory. Inventory items were generated by sampling naturally occurring automatic cognitions. Using principal component analysis, the findings showed a global factor of coping ability as well as six main factors: Emotional Coping, Behavioral Coping, Categorical Thinking, Personal Superstitious Thinking, Esoteric Thinking, and Naive Optimism. We tested the replicability of this factor structure and the amount of statistical independence (nonredundancy) between these factors in an initial study of German students (Study 1, N = 439) and in a second study of patients with chronic skin disorders (Study 2, N = 187). Factor congruence with the original (American) data was determined using a formula proposed by Schneewind and Cattell (1970) . Our findings show satisfactory factor congruence and statistical independence for Emotional Coping and Esoteric Thinking in both studies, while full replicability or independence could not be found in both for the other factors. Implications for the use and further development of the CTI are discussed.

167 Influence of Chronic Skin Diseases on Male Sexual Function in Upper Egypt

2017 ◽  
Vol 14 (2) ◽  
pp. e69
Author(s):  
H. Abdel Hafez ◽  
A.A. Abdel-Motaleb ◽  
H.D. Gaber ◽  
G.S.T. Al-Attar
Keyword(s):  
Sexual Function ◽  
Skin Diseases ◽  
Upper Egypt ◽  
Male Sexual Function ◽  
Chronic Skin ◽  
Chronic Skin Diseases

scholarly journals Influência de fatores emocionais nas doenças crônicas de pele: O estresse como gatilho para o desenvolvimento, reincidência ou agravamento da psoríase / Influence of emotional factors on chronic skin diseases: Stress as a trigger for development, recurrence or worsening of psoriasis

2019 ◽  
Vol 13 (46) ◽  
pp. 584-608
Author(s):  
Manuela Sobral Bentes de Melo ◽  
Nara Freire Leão Rocha ◽  
Stéfany Silva Magalhães ◽  
Lais Landim Sousa
Keyword(s):  
Skin Diseases ◽  
Emotional Factors ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Diversos estudos têm revelado a existência de uma relação entre aspectos psicossociais e o desenvolvimento ou agravamento de dermatoses crônicas, dentre as quais se encontra a psoríase. Fatores psicológicos, stress e outros eventos da vida são capazes de agravar de 40 e 80% dos casos. O estudo objetivou analisar a forma como esses aspectos podem ensejar o surgimento, a reincidência ou a acentuação do quadro clínico. Metodologia: Estudo de casos concretos com pacientes portadores da psoríase, além de uma vasta literatura bibliográfica acerca da temática. Conclusão: Ficou demonstrada a importância do tratamento psíquico e fisiológico, bem como a necessidade do desenvolvimento de estratégias de coping para enfretamento das situações sociais envolvidas.   

scholarly journals IL-17C and IL-17RE Promote Wound Closure in a Staphylococcus aureus-Based Murine Wound Infection Model

2021 ◽  
Vol 9 (9) ◽  
pp. 1821
Author(s):  
Linda Pätzold ◽  
Alexandra Stark ◽  
Felix Ritzmann ◽  
Carola Meier ◽  
Thomas Tschernig ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Wound Closure ◽  
Skin Diseases ◽  
Infection Model ◽  
Interleukin 17 ◽  
Immune Mediated ◽  
Significant Difference ◽  
Infected Skin

The epithelial cytokine interleukin-17C (IL-17C) mediates inflammation through the interleukin 17 receptor E (IL-17RE). Prior studies showed a detrimental role of IL-17C in the pathogenesis of immune-mediated skin diseases (e.g., psoriasis). Here, we examined the role of IL-17C/IL-17RE in wound closure in a Staphylococcus aureus wound infection model. We demonstrate that wound closure is significantly delayed in IL-17RE (Il-17re−/−)- and 17C (Il-17c−/−)-deficient mice. There was no significant difference between WT, Il-17re−/−, and Il-17c−/− mice in the absence of infection. Deficiency for IL-17RE and IL-17C did not significantly affect the elimination of bacteria. IL-17C expression was increased in the epidermis of human S. aureus-infected skin. Our results indicate that the IL-17C/IL-17RE axis contributes to the closure of infected wounds but does not contribute to the elimination of S. aureus.

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

Lupus ◽  
2018 ◽  
Vol 27 (7) ◽  
pp. 1202-1206 ◽  
Author(s):  
Y Satoh ◽  
K Nakano ◽  
H Yoshinari ◽  
S Nakayamada ◽  
S Iwata ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Psoriasis Vulgaris ◽  
Tissue Sample ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Biopsy Tissue ◽  
Interleukin 17A

It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated. After starting secukinumab the clinical and biological features were improved.

Comparison of Personality Traits among Patients with Psoriasis, Atopic Dermatitis, and Stress: A Pilot Study

Dermatology ◽  
2020 ◽  
Vol 236 (4) ◽  
pp. 324-328 ◽  
Author(s):  
Lynda Grine ◽  
Giulia Tochtermann ◽  
Hilde Lapeere ◽  
Nele Maes ◽  
Günther F.L. Hofbauer ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Personality Traits ◽  
Skin Diseases ◽  
Work Related Stress ◽  
Work Related ◽  
Chronic Skin ◽  
Related Stress ◽  
Chronic Skin Diseases ◽  
The Impact

Background: Psoriasis and atopic dermatitis are chronic skin diseases that greatly affect the quality of life. Both diseases can be triggered or exacerbated by stress. Objective: We aimed to differentiate personality traits between patients with chronic skin conditions and people treated for stress in a pilot study. Methods: Patients participating voluntarily in educational programs in Belgium and Switzerland were recruited to complete personality trait questionnaires, including the Temperament and Character Inventory (TCI) and the Tridimensional Personality Questionnaire (TPQ). A comparison was made with patients treated for work-related stress. Results: A total of 48 and 91 patients suffering from skin diseases and work-related stress, respectively, were included in the study. Based on the questionnaires, we found that dermatology patients were less persistent and impulsive than those with work-related stress. Dermatology patients also exhibited more rigidness and less focus on performance. Finally, patients with work-related stress seem more likely to change in response to health-promoting programs than patients with chronic dermatoses. Conclusion: Patients with chronic skin diseases may perceive and cope with stress differently in comparison to patients with work-related stress due to inherent personality traits. Therefore, stress coping mechanisms may differ among different diseases. More research is needed into the design of educational interventions and the impact of personality traits in disease-specific groups.

Biopolymeric films as delivery vehicles for controlled release of hydrocortisone: Promising devices to treat chronic skin diseases

2020 ◽  
Vol 114 ◽  
pp. 111074
Author(s):  
Guilherme T. Voss ◽  
Matheus S. Gularte ◽  
Renata L. de Oliveira ◽  
Cristiane Luchese ◽  
André R. Fajardo ◽  
...  
Keyword(s):  
Controlled Release ◽  
Skin Diseases ◽  
Delivery Vehicles ◽  
Chronic Skin ◽  
Chronic Skin Diseases
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