scholarly journals Alcoholic Cirrhosis with Zinc and Copper Co-Deficiency

2019 ◽  
Vol 2 (1-3) ◽  
pp. 8-15
Author(s):  
Chanita Unhapipatpong ◽  
Daruneewan Warodomwichit ◽  
Kumutnart Chanprapaph
Keyword(s):  
Alcohol Consumption ◽  
Zinc Deficiency ◽  
Copper Deficiency ◽  
Zinc Supplementation ◽  
Alcoholic Cirrhosis ◽  
Oral Antibiotics ◽  
Excessive Alcohol Consumption ◽  
History Of ◽  
Excessive Alcohol

A 54-year-old Thai female with known alcoholic cirrhosis presented with chronic scaly eczematous patches and plaque for over 1 month. Initially, she was treated with oral antibiotics, but the lesions did not improve. The dermatologic examination and history of alcoholic cirrhosis were compatible with zinc deficiency. Moreover, copper deficiency was found together with zinc deficiency. Excessive alcohol consumption can cause zinc and copper co-deficiency. To avoid aggravated copper deficiency after zinc supplementation, copper and zinc were supplemented together in appropriate proportions. On the 2-week follow-up examination, her clinical outcome improved.

scholarly journals Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 39
Author(s):  
Akihiko Shibamoto ◽  
Tadashi Namisaki ◽  
Junya Suzuki ◽  
Takahiro Kubo ◽  
Satoshi Iwai ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Biological Markers ◽  
Prediction Accuracy ◽  
Total Bilirubin ◽  
Alcoholic Cirrhosis ◽  
Serum Total Bilirubin ◽  
Excessive Alcohol Consumption ◽  
Significant Difference ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol

: Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

Characteristics, management and outcomes of patients with hepatocarcinoma in a low-income country.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16166-e16166
Author(s):  
Jennifer Dominguez ◽  
Bonnie Macario ◽  
Rixci Ramirez ◽  
Mario Daniel Castro
Keyword(s):  
Alcohol Consumption ◽  
Liver Cancer ◽  
Low Income ◽  
Cox Regression ◽  
Target Therapy ◽  
Income Country ◽  
Rank Test ◽  
Excessive Alcohol Consumption ◽  
History Of ◽  
Excessive Alcohol

e16166 Background: Worldwide, every year, there are nearly 905,000 patients diagnosed with liver cancer; it is the sixth most common malignancy and the third most lethal malignancy. Almost three quarters of new patients live in areas with low and medium-income country. Guatemala has the highest mortality and incidence of liver cancer. Objectives: Describe the clinical characteristics, main risk factors, treatment and outcomes of patients with hepatocarcinoma (HCC) in Guatemala. Methods: A retrospective review was performed among patients with HCC from January 2002 to December 2019 in the Instituto Guatemalteco de Seguridad Social (IGSS). Kaplan Meier curves, Cox regression and log-rank test were used to calculate overall survival (OS) and mortality. Results: 140 patients with HCC were analyzed, 114 women and 26 men with a median age of 60 years (20 - 99), 102 patients (73%) have history of excessive alcohol consumption and 11 (8%) has history of chronic hepatitis B or C virus infection. All of the patients have liver cirrhosis, Child-Pugh A 100 patients (71%), B 34 (24%) and C 6 (5%). 10 patients (7%) have HCC BCLC A, 0 (0%) BCLC B, 121 (81%) BCLC C and 9 (6%) BCLC D. All patients with HCC BCLC A received surgical treatment with a median OS of 123 months (95% CI 89 - 156 p < 0.001). 122 patients (89%) received target therapy with Sorafenib with a median OS of 17 months (95% CI 12 - 21 p < 0.001) and 8 patients (6%) underwent to chemoembolization with a median OS of 32 months (95% CI 12 - 52 p < 0.001). At this time, 111 patients (79%) died from the disease, 11 (8%) are alive with the disease and 8 (6%) are alive without disease. Conclusions: The most frequent risk factor for HCC is the excessive alcohol consumption, survival of patients with HCC are associated with treatment at the beginning of the disease.

scholarly journals Association of MAFLD with diabetes, chronic kidney disease, and cardiovascular disease: a 4.6-year cohort study in China

2021 ◽  
Author(s):  
Yebei Liang ◽  
Hongli Chen ◽  
Yuexing Liu ◽  
Xuhong Hou ◽  
Li Wei ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Alcohol Consumption ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hbv Infection ◽  
Incident Diabetes ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

Abstract Context In 2020, the terminology of metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace non-alcoholic fatty liver disease (NAFLD). Objectives: To investigate the prevalence and incidence of MAFLD and evaluate its impacts on incident extrahepatic diseases. Methods A total of 6,873 subjects, with a 4.6-year follow-up, were included into this study. Associations of MAFLD and NAFLD with diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD) were examined using logistic regression and Cox proportional hazards models. Results The prevalence of NAFLD and MAFLD was 40.3% (95% confidence interval [CI] 39.2-41.5) and 46.7% (95% CI 45.6-47.9), respectively. Additionally, 321 (4.7%) and 156 (2.3%) subjects had MAFLD with excessive alcohol consumption and hepatitis B virus (HBV) infection. During the follow-up period, the incidence of NAFLD and MAFLD was 22.7% (95% CI 21.3-24.0) and 27.0% (95% CI 25.5-28.4). MAFLD was associated with higher risks of incident diabetes (risk ratio [RR] 2.08, 95% CI 1.72-2.52), CKD (RR 1.64, 95% CI 1.39-1.94), and CVD (hazard ratio 1.44, 95% CI 1.15-1.81). Similar associations for NAFLD were observed. Furthermore, the MAFLD subgroups with excessive alcohol consumption (RR 2.49, 95% CI 1.64-3.78) and HBV infection (RR 1.98, 95% CI 1.11-3.52) were associated with higher risks of incident diabetes. Conclusions The change from NAFLD to MAFLD did not affect the associations with diabetes, CKD, and CVD much. MAFLD further identified those patients of metabolically fatty liver combined with excessive alcohol consumption and HBV infection, who had increased risks of incident diabetes compared with those of non-fatty liver.

Hyperregenerative macrocytic anaemia: the role of copper and zinc

2021 ◽  
Vol 14 (4) ◽  
pp. e241028
Author(s):  
Patrick Hofmann ◽  
Claudia Buetikofer ◽  
Esther Bächli
Keyword(s):  
Bariatric Surgery ◽  
Copper Deficiency ◽  
Zinc Supplementation ◽  
Corpuscular Volume ◽  
Copper Uptake ◽  
Macrocytic Anaemia ◽  
Short Bowel ◽  
History Of

In a patient with a history of bariatric surgery, severe copper deficiency presenting with macrocytic hyperregenerative anaemia was diagnosed. Besides the impaired intestinal absorption due to a short bowel syndrome, the enteral zinc supplementation competitively decreased the intestinal copper uptake. Once the zinc supplementation was stopped, enteral copper replacement ensued and normalised haemoglobin levels with decreasing median corpuscular volume were observed during follow-up visits.

scholarly journals Alcohol consumption as a risk factor for anxiety and depression

2005 ◽  
Vol 187 (6) ◽  
pp. 544-551 ◽  
Author(s):  
Jonathan C. Haynes ◽  
Michael Farrell ◽  
Nicola Singleton ◽  
Howard Meltzer ◽  
Ricardo Araya ◽  
...  
Keyword(s):  
Risk Factor ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Binge Drinking ◽  
Psychiatric Morbidity ◽  
Anxiety And Depression ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
New Onset

BackgroundLongitudinal studies have been inconclusive in identifying alcohol as a risk factor for anxiety and depression.AimsTo examine whether excessive alcohol consumption is a risk factor for anxiety and depression in the general population, and whether anxiety and depression are risk factors for excessive alcohol consumption.MethodData were analysed from the 18-month follow-up of the Psychiatric Morbidity Among Adults Living in Private Households, 2000 survey.ResultsHazardous and dependent drinking were not associated with onset of anxiety and depression at follow-up. Binge-drinking was non-significantly associated with incident anxiety and depression (adjusted OR= 1.36, 95% CI 0.74–2.50). Abstainers were less likely to have new-onset anxiety and depression at follow-up. Anxiety and depression or sub-threshold symptoms at baseline were not associated with incident hazardous or binge-drinking at follow-up, but there was weak evidence linking sub-threshold symptoms with onset of alcohol dependence (adjusted OR=2.04, 95% CI 0.84–4.97).ConclusionsExcessive alcohol consumption was not associated with the onset of anxiety and depression but abstinence was associated with a lower risk. Sub-threshold symptoms were weakly associated with new-onset alcohol dependence.

scholarly journals A case of stricture-type ischemic colitis from excessive alcohol consumption, with follow-up to rule out colon cancer

2020 ◽  
Vol 66 (1) ◽  
pp. 60-65
Author(s):  
Yu Watahiki ◽  
Keietsu Saito ◽  
Yuto Ishizaki ◽  
Kuniyoshi Yamanobe ◽  
Keiichi Sagawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Alcohol Consumption ◽  
Ischemic Colitis ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
Rule Out

scholarly journals Risk factors and clinical features of recurrent stroke in the Tyva Republic

2014 ◽  
Vol 95 (2) ◽  
pp. 199-202
Author(s):  
Kh D Mongush ◽  
A B Ondar ◽  
R Ch Chylbak-ool ◽  
M B Balchir ◽  
Ch O Mongush
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Alcohol Consumption ◽  
Arterial Hypertension ◽  
Recurrent Stroke ◽  
Excessive Alcohol Consumption ◽  
Stroke Group ◽  
History Of ◽  
Excessive Alcohol ◽  
Male Patients

Aim. To determine risk factors and clinical features of the recurrent stroke. Methods. A prospective 3-year cohort study was conducted including 120 patients with stroke admitted to the neurological department of the Republican Hospital №1 of Kyzyl at 2010-2012, 60 of whom had recurrent stroke (group 1), and 60 had primary stroke (group 2). Results. Recurrent stroke was by 16.66% more common in men. The mean age of males having recurrent stroke was younger compared to females (р 0.05). Patients with family history of arterial hypertension in closest relatives were significantly more prevalent among those with recurrent stroke (70 versus 35%, p 0.05). The rate of excessive alcohol consumption was also significantly higher in patients with recurrent stroke (18.33 versus 6.67%, p 0.05). Mortality associated with the recurrent stroke was higher in males of all age groups, difference was statistically significant in male patients over 70 years of age (p 0.05). Combined first 28-day mortality was 26.67% (32 cases), and was higher in patients with primary stroke (p 0.05). Only 21.67% of patients took antihypertensives regularly prior to the primary stroke, among patients with recurrent stroke this share reached 70%. Antiplatelet drugs were taken by 5% of patients prior to the primary stroke, in patients who suffered the stroke the share was higher and reached 53.33%. Conclusion. Family history of arterial hypertension was the most important risk factor for recurrent stroke. Male patients had higher risks of recurrent stroke and fatal outcome, which may be associated with lower drug compliance (including antiplatelet drugs and anticoagulants, antihypertensives) and higher exposure to other risk factors (smoking, excessive alcohol consumption).

scholarly journals Copper deficiency caused by excessive alcohol consumption

2017 ◽  
pp. bcr-2017-220921 ◽  
Author(s):  
Shunichi Shibazaki ◽  
Shuhei Uchiyama ◽  
Katsuji Tsuda ◽  
Norihide Taniuchi
Keyword(s):  
Alcohol Consumption ◽  
Copper Deficiency ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

scholarly journals To the problem of excessive alcohol consumption in Russian families

2020 ◽  
Vol 26 (4) ◽  
pp. 142-160
Author(s):  
E. N. Novoselova
Keyword(s):  
Alcohol Consumption ◽  
Family Members ◽  
Alcoholic Beverages ◽  
World Health ◽  
Federal State ◽  
Excessive Alcohol Consumption ◽  
Working Age ◽  
History Of ◽  
Excessive Alcohol ◽  
Health Organization

The article is devoted to the analysis of alcoholism in Russian families. The author gives a brief excurse into the history of alcohol consumption, dispels the myth that the Russian people never controlled consumption of alcoholic beverages. The work, relying on the latest statistics, demonstrated that despite the emerging positive trends in this area, the level of alcohol consumption (especially strong alcohol) in Russia is still very high and significantly exceeds the conditionally safe norm indicated by the WHO experts. It negatively affects the life expectancy of the Russian population, especially among men of working age. However, if previously alcoholism was predominantly masculine, today this type of addiction is becoming gender-neutral and women drink on a par with men, which will inevitably lead to an increase in mortality from alcohol-related causes among them.Particular attention is paid to the problems of families facing the problem of alcoholism among one or several of their members. It is emphasized that children are the most vulnerable in this situation because of their dependence on adults — they are not able to change the situation and are forced to live in constant conflict, stress and ill-treatment. The author notes that the violence to which not only children, but also other family members are subjected to in alcoholic families, is far from rare and extremely dangerous.The paper addresses the issue of the influence of alcoholism of adult family members on children's health. Children of dependent parents are often born sick and lag behind in physical and mental development. This is further aggravated by upbringing in an atmosphere of alcoholism, which leads to the fact that the younger generation perceives excessive alcohol consumption as the norm, adopts the habits of parents and also become dependent. Children of drinking parents also experience many complexities of a personal and interpersonal nature and are prone to auto-aggressive behavior.In conclusion, the author addresses the problem of social orphanhood arising from alcohol abuse by parents, as well as its consequences.The empirical part of the work is based on data from the World Health Organization, the Federal State Statistics Service, the Public Opinion Foundation and the All-Russian Center for the Study of Public Opinion.The article will be of interest to specialists in the field of sociology of family and health, prevention of addictive behavior, rehabilitation of people with addictions, and students of relevant specialties.

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