Higher in vivo Cortical Intracellular Volume Fraction Associated with Lithium Therapy in Bipolar Disorder: A Multicenter NODDI Study

2019 ◽  
Vol 88 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Samuel Sarrazin ◽  
Cyril Poupon ◽  
Achille Teillac ◽  
Jean-François Mangin ◽  
Mircea Polosan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Volume Fraction ◽  
Lithium Therapy ◽  
Intracellular Volume

Lithium therapy in bipolar disorder is associated with higher in-vivo cortical neurite density

2019 ◽  
Vol 29 ◽  
pp. S38-S39
Author(s):  
S. Sarrazin ◽  
C. Poupon ◽  
A. Teillac ◽  
J.F. Mangin ◽  
M. Polosan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Lithium Therapy ◽  
Neurite Density

Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts

1990 ◽  
Vol 259 (4) ◽  
pp. H1086-H1096 ◽  
Author(s):  
J. M. Capasso ◽  
T. Palackal ◽  
G. Olivetti ◽  
P. Anversa
Keyword(s):  
Ventricular Remodeling ◽  
Volume Fraction ◽  
Diastolic Pressure ◽  
Structural Characteristics ◽  
Myocardial Dysfunction ◽  
Pressure Rise ◽  
Wall Stress ◽  
Left Ventricular ◽  
Cross Sectional

To determine if aging engenders alterations in the functional properties of the myocardium and ventricular remodeling, the hemodynamic performance and structural characteristics of the left ventricle of male Fischer 344 rats at 4, 12, 20, and 29 mo of age were studied by quantitative physiology and morphology. In vivo assessment of cardiac pump function showed no change up to 20 mo, whereas left ventricular end-diastolic pressure was increased at 29 mo. Moreover, peak rates of pressure rise and decay, stroke volume, ejection fraction, and cardiac output were depressed at the later age interval, demonstrating the presence of ventricular failure at this time. The measurements of chamber size and wall thickness showed that ventricular end-diastolic and end-systolic volumes progressively increased with age with the greatest change occurring at 20-29 mo. Aging was also accompanied by a marked augmentation in the volume fraction of fibrotic areas in the ventricular myocardium that was due to an increase in their number and cross-sectional area with time. These architectural rearrangements, in combination with the abnormalities in ventricular function, resulted in an elevation in the volume of wall stress throughout the cardiac cycle. Wall stress increased by 64, 44, and 50% from 4 to 12, 12 to 20, and 20 to 29 mo of age. In conclusion, aging leads to a continuous rise in wall stress that is not normalized by ventricular remodeling. These two independent processes appear to be responsible for the onset of heart failure in the senescent rat.

scholarly journals In vivo evaluation of cortical thickness with magnetic resonance imaging in patients with bipolar disorder

2009 ◽  
Vol 2 (2) ◽  
Author(s):  
Thomas Martin Doring ◽  
Tadeu Takao Almodovar Kubo ◽  
Juliana Rodrigues Doring ◽  
Jiosef Fainberg ◽  
Mario Juruena ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bipolar Disorder ◽  
Magnetic Resonance ◽  
Cortical Thickness ◽  
Resonance Imaging ◽  
In Vivo Evaluation

In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

2007 ◽  
Vol 116 (6) ◽  
pp. 467-472 ◽  
Author(s):  
A. Fornito ◽  
G. S. Malhi ◽  
J. Lagopoulos ◽  
B. Ivanovski ◽  
S. J. Wood ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization

2020 ◽  
Author(s):  
Estêvão Scotti-Muzzi ◽  
Thais Chile ◽  
Ricardo Moreno ◽  
Bruno Fraccini Pastorello ◽  
Cláudia da Costa Leite ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mood Stabilization

Three-Dimensional Characterization of the Microstructure of Bioglass/Polyethylene Composite by X-Ray Microtomography

2007 ◽  
Vol 330-332 ◽  
pp. 503-506
Author(s):  
Xiao Wei Fu ◽  
Jie Huang ◽  
E.S. Thian ◽  
Serena Best ◽  
William Bonfield
Keyword(s):  
Spatial Distribution ◽  
Volume Fraction ◽  
Three Dimensional ◽  
X Ray ◽  
Polyethylene Composite ◽  
Bioactive Properties ◽  
Recent Developments ◽  
3D Information

A Bioglass® reinforced polyethylene (Bioglass®/polyethylene) composite has been prepared, which combines the high bioactivity of Bioglass® and the toughness of polyethylene. The spatial distribution of Bioglass® particles within the composite is important for the performance of composites in-vivo. Recent developments in X-ray microtomography (XμT) have made it possible to visualize internal and microstructural details with different X-ray absorbencies, nondestructively, and to acquire 3D information at high spatial resolution. In this study, the volume fraction and 3D spatial distribution of Bioglass® particles has been acquired quantitatively by XμT. The information obtained provides a foundation for understanding the mechanical and bioactive properties of the Bioglass®/polyethylene composites.

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