Circulating Iron Levels Interaction with Central Obesity on the Risk of Nonalcoholic Fatty Liver Disease: A Case–Control Study in Southeast China

2019 ◽  
Vol 74 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Xinting Pan ◽  
Bingbing Chen ◽  
Wenjuan Liu ◽  
Yangfan Li ◽  
Zhijian Hu ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Central Obesity ◽  
Case Control Study ◽  
Elevated Serum ◽  
Case Control ◽  
Nonalcoholic Fatty Liver ◽  
Serum Hepcidin ◽  
Control Study

Objectives: We aimed to evaluate the associations between body iron stores and the risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese population and explore whether this effect may be modified by other factors. Methods: A 1: 1 frequency-matched case–control study was conducted, including 482 NAFLD cases and 490 gender- and age-matched controls. Serum levels of ferritin, hepcidin, and C-reactive protein were measured. Results: Multivariate logistic regression analysis showed that hepcidin was not associated with NAFLD risk; however, elevated serum ferritin was significantly associated with increased risk of NAFLD (adjusted OR 1.619, 95% CI 1.158–2.267), and hepcidin:ferritin ratio was significantly associated with decreased risk of NAFLD ­(OR­adjusted 0.702, 95% CI 0.501–0.984). When stratified by gender, a significant association was found between elevated serum ferritin and hepcidin:ferritin ratio and NAFLD only for women (ORadjusted 2.131, 95% CI 1.151–3.944 and ORadjusted 0.414, 95% CI 0.219–0.781, respectively). A significant multiplicative interaction between central obesity and elevated serum hepcidin was observed (p < 0.05). Conclusions: Elevated serum ferritin and hepcidin:ferritin ratio are associated with NAFLD in a Chinese population. Although serum hepcidin is not associated with NAFLD, it may augment the risk effect of central obesity on NAFLD.

scholarly journals Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study

2011 ◽  
Vol 164 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Chloe Y Y Cheung ◽  
Annette W K Tso ◽  
Bernard M Y Cheung ◽  
Aimin Xu ◽  
K L Ong ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Genetic Risk ◽  
Chinese Population ◽  
Central Obesity ◽  
Case Control Study ◽  
Case Control ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Control Study

ObjectiveCentral obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort.Design and methodsWe genotyped these SNPs in i) 354 subjects with and 994 subjects without central obesity at both baseline and a 12-year follow-up, ii) 2214 subjects (816 cases and 1398 controls) in an MetS cross-sectional case–control study and iii) 225 subjects with and 1221 subjects without MetS at both baseline and the 12-year follow-up.ResultsBoth FTO rs8050136 (Page, sex-adjusted=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (Page, sex-adjusted=3×10−3; OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity. GNPDA2 rs10938397 was also significantly associated with MetS (Page, sex-adjusted=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case–control study. However, none of these SNPs showed an individual association with persistent MetS. In the combined genetic risk analyses for persistent central obesity and persistent MetS, the combined genetic risk score of the three SNPs showed an OR of 1.25 (95% CI: 1.10, 1.42; Page, sex-adjusted=4.92×10−3) and 1.19 (95% CI: 1.03, 1.38; Page, sex-adjusted=0.019) for each additional risk allele respectively.ConclusionThis study demonstrated that FTO and GNPDA2 variants predicted persistent central obesity in the Chinese population, further supporting their importance as obesity-susceptible genes.

scholarly journals Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yvonne N. Flores ◽  
Aryana T. Amoon ◽  
Baolong Su ◽  
Rafael Velazquez-Cruz ◽  
Paula Ramírez-Palacios ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver Disease ◽  
Serum Lipids ◽  
Case Control Study ◽  
Case Control ◽  
Ultrasound Elastography ◽  
Healthy Controls ◽  
Nonalcoholic Fatty Liver ◽  
Liver Ultrasound ◽  
Control Study

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, and diabetes. The aim of this study was to better understand differences in the lipid composition of individuals with NAFLD compared to controls, by performing direct infusion lipidomics on serum biospecimens from a cohort study of adults in Mexico. Methods A nested case-control study was conducted with a sample of 98 NAFLD cases and 100 healthy controls who are participating in an on-going, longitudinal study in Mexico. NAFLD cases were clinically confirmed using elevated liver enzyme tests and liver ultrasound or liver ultrasound elastography, after excluding alcohol abuse, and 100 controls were identified as having at least two consecutive normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (< 40 U/L) results in a 6-month period, and a normal liver ultrasound elastography result in January 2018. Samples were analyzed on the Sciex Lipidyzer Platform and quantified with normalization to serum volume. As many as 1100 lipid species can be identified using the Lipidyzer targeted multiple-reaction monitoring list. The association between serum lipids and NAFLD was investigated using analysis of covariance, random forest analysis, and by generating receiver operator characteristic (ROC) curves. Results NAFLD cases had differences in total amounts of serum cholesterol esters, lysophosphatidylcholines, sphingomyelins, and triacylglycerols (TAGs), however, other lipid subclasses were similar to controls. Analysis of individual TAG species revealed increased incorporation of saturated fatty acyl tails in serum of NAFLD cases. After adjusting for age, sex, body mass index, and PNPLA3 genotype, a combined panel of ten lipids predicted case or control status better than an area under the ROC curve of 0.83. Conclusions These preliminary results indicate that the serum lipidome differs in patients with NAFLD, compared to healthy controls, and suggest that assessing the desaturation state of TAGs or a specific lipid panel may be useful clinical tools for the diagnosis of NAFLD.

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