scholarly journals Secretion of Gut Hormones and Expression of Sweet Taste Receptors and Glucose Transporters in a Rat Model of Obesity

Obesity Facts ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Ri Lu Feng ◽  
Cheng Qian ◽  
Lian Yong Liu ◽  
Qian Jing Liu ◽  
Yun Qiu Jin ◽  
...  
Keyword(s):  
Rat Model ◽  
Gut Hormones ◽  
Glucose Transporters ◽  
Sweet Taste ◽  
Taste Receptors ◽  
Sweet Taste Receptors

Effects of Metformin and Sitagliptin Monotherapy on Expression of Intestinal and Renal Sweet Taste Receptors and Glucose Transporters in a Rat Model of Type 2 Diabetes

2020 ◽  
Vol 52 (05) ◽  
pp. 329-335
Author(s):  
Minchun Zhang ◽  
Rilu Feng ◽  
Jiang Yue ◽  
Cheng Qian ◽  
Mei Yang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Glucose Transporters ◽  
Sweet Taste ◽  
Glucose Absorption ◽  
Taste Receptors ◽  
Mrna Levels ◽  
Sweet Taste Receptors ◽  
Incretin Secretion ◽  
Zdf Rats

AbstractDisordered intestinal sweet taste receptors (STRs) are implicated in glucose homeostasis by involving in incretin secretion and glucose absorption. However, the effects of antidiabetic medications on STRs, downstream molecules, and glucose transporters expression are unknown. In our study, ZDF rats (n=24) were randomly treated by metformin (MET, 215.15 mg/kg), sitagliptin (SIT, 10.76 mg/kg), or saline for 4 weeks. Fasting blood glucose and insulin levels were measured, and HOMA-IR and QUICKI index were calculated. One week later, we detected relative mRNA expression of T1R2/T1R3, α-gustducin, TRPM5 and glucose transporters including SGLT1, SGLT2, and GLUT2 in the small intestine and kidney. We found that though both metformin and sitagliptin effectively decreased fasting blood glucose, only metformin improved HOMA-IR and QUICKI (p<0.05). MRNA levels of STRs and sweet taste molecules in duodenum and jejunum were not different among three groups, but those in ileum were dramatically upregulated after SIT (vs. MET p<0.05; vs. CON p<0.01). SGLT1 and GLUT2 in ileum were markedly increased after SIT (p<0.01). In the kidney, expression of SGLT2 and GLUT2 were downregulated in both SIT and MET group (p<0.05). In conclusion, metformin and sitagliptin exerted different effects on expression of STRs and glucose transporters in the gut and kidney. STRs, downstream molecules, and glucose transporters in distal small intestinal were sensitively increased in response to sitagliptin than metformin treatment. Renal glucose transporters were downregulated after metformin and sitagliptin treatment.

Low intake of digestible carbohydrates ameliorates the duodenal absorption of carbohydrates in mice with glucose metabolic disorders induced by sucralose

2018 ◽  
Vol 9 (12) ◽  
pp. 6236-6244 ◽  
Author(s):  
Qing Shi ◽  
Xuemei Zhu ◽  
Jue Zhou ◽  
Lianlian Chen
Keyword(s):  
Plasma Glucose ◽  
Metabolic Disorders ◽  
Glucose Transporters ◽  
Sweet Taste ◽  
Taste Receptors ◽  
Protective Effects ◽  
Fasting Insulin ◽  
Sweet Taste Receptors ◽  
Glucose Plasma

In the current study, the protective effects of diets with low digestible carbohydrates (LDCs) on plasma glucose, plasma fasting insulin, sweet taste receptors, glucose transporters and absorption of carbohydrates in mice that consume sucralose were evaluated.

495-P: Kidney May Regulate SGLT2-Dependent Glucose Reabsorption through Sweet Taste Receptors: Implications for Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 495-P
Author(s):  
LUPING ZHOU ◽  
WEI HUANG ◽  
NAN LIU ◽  
XIU M. MA ◽  
MAN GUO ◽  
...  
Keyword(s):  
Sweet Taste ◽  
Taste Receptors ◽  
Glucose Reabsorption ◽  
Sweet Taste Receptors

scholarly journals Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat

2013 ◽  
Vol 183 (2) ◽  
pp. 606-611 ◽  
Author(s):  
Rizwan M. Chaudhry ◽  
Alok Garg ◽  
Mohamed M. Abdelfatah ◽  
Judith A. Duenes ◽  
Michael G. Sarr
Keyword(s):  
Sweet Taste ◽  
Taste Receptors ◽  
Sweet Taste Receptors

scholarly journals Mammalian Sweet Taste Receptors

Cell ◽  
2001 ◽  
Vol 106 (3) ◽  
pp. 381-390 ◽  
Author(s):  
Greg Nelson ◽  
Mark A. Hoon ◽  
Jayaram Chandrashekar ◽  
Yifeng Zhang ◽  
Nicholas J.P. Ryba ◽  
...  
Keyword(s):  
Sweet Taste ◽  
Taste Receptors ◽  
Sweet Taste Receptors

scholarly journals Sugars, Sweet Taste Receptors, and Brain Responses

Nutrients ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 653 ◽  
Author(s):  
Allen Lee ◽  
Chung Owyang
Keyword(s):  
Sweet Taste ◽  
Taste Receptors ◽  
Brain Responses ◽  
Sweet Taste Receptors
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