The Role of Ancillary Techniques in Salivary Gland Cytopathology Specimens

2019 ◽  
Vol 64 (1-2) ◽  
pp. 92-102 ◽  
Author(s):  
Kimberly Point du Jour ◽  
Christopher C. Griffith
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Molecular Characteristics ◽  
Malignant Neoplasms ◽  
Benign Neoplasms ◽  
Gland Tumor ◽  
Aspiration Cytology ◽  
Preoperative Test ◽  
Neoplastic Lesions

Salivary gland tumor aspiration cytology is a useful preoperative test to guide the most appropriate clinical and surgical management for these patients. Although salivary gland cytology is often useful to distinguish between non-neoplastic lesions, benign neoplasms and malignant neoplasms, there remain many challenges in this area. Specifically, these tumors are uncommon and may have considerable morphologic overlap, especially in the setting of a malignant tumor. This article reviews some of the immunohistochemical and molecular characteristics of more common salivary gland neoplasms that pathologists and cytotechnologists may encounter. When used in combination with morphologic features, such ancillary testing can be useful to further refine the differential diagnosis, more strongly favor a particular entity, or in some instances confidently provide a specific diagnosis.

scholarly journals Basal cell adenoma of the parotid gland: A rare entity

2021 ◽  
pp. 014556132110455
Author(s):  
Nouha Ben Abdeljelil ◽  
Mohamed Masmoudi ◽  
Wadii Thabet ◽  
Ahlem Bellalah ◽  
Ezer Chebil ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Basal Cell ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Basal Cell Adenoma ◽  
Gland Tumor ◽  
Aspiration Cytology ◽  
Cell Adenoma ◽  
Needle Aspiration Cytology

Basal cell adenoma (BCA) is a rare benign salivary gland tumor accounting for only 1–2% of all salivary gland tumors. We report a case of a 50-year-old man presenting a BCA of the parotid gland. A pleomorphic adenoma was initially suspected based on radiological features and fine needle aspiration cytology findings (FNAC).

scholarly journals Salivary Gland Tumor Fine-Needle Aspiration Cytology

2015 ◽  
Vol 143 (6) ◽  
pp. 839-853 ◽  
Author(s):  
Christopher C. Griffith ◽  
Reetesh K. Pai ◽  
Frank Schneider ◽  
Umamaheswar Duvvuri ◽  
Robert L. Ferris ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Gland Tumor ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Epidemiological profile of salivary gland lesions diagnosed in a higher education institution: an observational and retrospective study of 381 cases

2020 ◽  
Vol 42 ◽  
pp. e51032
Author(s):  
Claudio Freire Sesenta Junior ◽  
Camila Camarini ◽  
Isadora Balan ◽  
Lilian Cristina Vessoni Iwaki ◽  
Mariliani Chicarelli da Silva ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Medical Records ◽  
Education Institution ◽  
Malignant Neoplasms ◽  
Anatomical Location ◽  
Benign Neoplasms ◽  
State University ◽  
Neoplastic Lesions ◽  
Epidemiological Profile ◽  
Microscopic Diagnosis

The aim of this retrospective and observational study was to report the prevalence and characteristics of salivary gland lesions (SGL) in patients treated at the State University of Maringa, between 1995 and 2018. Data from medical records of patients with neoplastic and non-neoplastic SGL concerning to age, sex, ethnicity, anatomical location, microscopic diagnosis and treatment were collected. All SGL with diagnosis confirmed by microscopic examination were considered. Of the 3,127 biopsied lesions, 381 (12.1%) SGL were identified. Caucasian (71%) women (51%) aging from 11 to 20 years (33%) were more affected. 88.5% (n= 337) were non-neoplastic lesions, 7% (n= 27) benign neoplasms and 4.5% (n= 17) malignant neoplasms. Mucocele was the most prevalent lesion (n= 269%), followed by pleomorphic adenoma (n= 25%). Recognition and appropriate management of these lesions is essential, especially because malignant neoplastic lesions of the salivary glands can be very aggressive.

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

scholarly journals N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Candace A. Frerich ◽  
Hailey N. Sedam ◽  
Huining Kang ◽  
Yoshitsugu Mitani ◽  
Adel K. El-Naggar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Transcriptional Activity ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Rna Seq ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Myb Proteins ◽  
Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

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