Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Dermatology ◽  
2019 ◽  
Vol 235 (3) ◽  
pp. 196-204 ◽  
Author(s):  
Juan Xiang ◽  
Hua Wang ◽  
Tingyu Li
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Vitamin A ◽  
Peripheral Blood ◽  
High Performance ◽  
Blood Eosinophil ◽  
Normal Children ◽  
Study Objective ◽  
Peripheral Blood Eosinophil ◽  
Eosinophil Counts

Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

Atopische Dermatitis: Die Frage nach dem Einfluss von Vitaminen bleibt weiter offen

2020 ◽  
Vol 8 (1) ◽  
pp. 19-20
Author(s):  
Regina Fölster-Holst
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
High Performance ◽  
Atopische Dermatitis ◽  
Serum Levels ◽  
Blood Eosinophil ◽  
Normal Children ◽  
Study Objective ◽  
Peripheral Blood Eosinophil ◽  
Eosinophil Counts

Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson's correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

scholarly journals The role of peripheral blood eosinophil counts in COVID‐19 patients

Allergy ◽  
2020 ◽  
Author(s):  
Guogang Xie ◽  
Fengming Ding ◽  
Lei Han ◽  
Dongning Yin ◽  
Hongzhou Lu ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Eosinophil Counts

Eosinophilia as a marker of resistance to Teladorsagia circumcincta in Scottish Blackface lambs

Parasitology ◽  
2002 ◽  
Vol 124 (5) ◽  
pp. 553-560 ◽  
Author(s):  
M. J. STEAR ◽  
N. G. HENDERSON ◽  
A. KERR ◽  
Q. A. MCKELLAR ◽  
S. MITCHELL ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Gastrointestinal Nematodes ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Teladorsagia Circumcincta ◽  
Peripheral Eosinophil ◽  
Faecal Egg Counts ◽  
Eosinophil Counts

Faecal egg counts and peripheral blood eosinophil counts were taken from Scottish Blackface lambs following natural, predominantly Teladorsagia circumcincta infection. Peripheral eosinophil concentrations were higher in animals with lower egg counts but only in lambs that were at least 3 months of age. The reduced egg counts were due to reduced fecundity of T. circumcincta; there was no association with the number of adult T. circumcincta. Associations with the number of parasites from other species of gastrointestinal nematodes appeared to be neutral or favourable. Estimated heritabilities for eosinophil concentrations in 4- and 5-month-old lambs were 0·48±0·16 and 0·43±0·17, respectively. Therefore, under defined circumstances, eosinophil concentrations may be a useful indicator of resistance to predominantly T. circumcincta infection.

Decreased Peripheral Blood Eosinophil Counts in Severe Psoriatic Patients Treated with Low-Dose Cyclosporine A

Dermatology ◽  
1992 ◽  
Vol 185 (3) ◽  
pp. 202-204 ◽  
Author(s):  
J.L. Shupack ◽  
C. Kenny ◽  
L. Jondreau ◽  
I. Eckman ◽  
C. Gropper ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Peripheral Blood ◽  
Low Dose ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Eosinophil Counts

scholarly journals Prevalence and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis: a single-center prospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haiyan Sheng ◽  
Xiujuan Yao ◽  
Xiangdong Wang ◽  
Yuhong Wang ◽  
Xiaofang Liu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Chronic Rhinosinusitis ◽  
Peripheral Blood ◽  
Scoring System ◽  
Severe Disease ◽  
Airflow Obstruction ◽  
Blood Eosinophil ◽  
Severe Exacerbation ◽  
Peripheral Blood Eosinophil ◽  
Eosinophil Counts

Abstract Background As a typical “united airway” disease, asthma-chronic rhinosinusitis (CRS) overlap has recently drawn more attention. Bronchiectasis is a heterogeneous disease related to a variety of diseases. Whether bronchiectasis exists and correlates with asthma-CRS patients has not been fully elucidated. The purpose of the study was to explore the presence and characteristics of bronchiectasis in patients with overlapping asthma and CRS. Methods This report describes a prospective study with consecutive asthma-CRS patients. The diagnosis and severity of bronchiectasis were obtained by thorax high-resolution computed tomography (HRCT), the Smith radiology scale and the Bhalla scoring system. CRS severity was evaluated by paranasal sinus CT and the Lund-Mackay (LM) scoring system. The correlations between bronchiectasis and clinical data, fraction of exhaled nitric oxide, peripheral blood eosinophil counts and lung function were analyzed. Results Seventy-two (40.91%) of 176 asthma-CRS patients were diagnosed with bronchiectasis. Asthma-CRS patients with overlapping bronchiectasis had a higher incidence rate of nasal polyps (NPs) (P = 0.004), higher LM scores (P = 0.044), higher proportion of ≥ 1 severe exacerbation of asthma in the last 12 months (P = 0.003), lower postbronchodilator forced expiratory volume in one second (FEV1) % predicted (P = 0.006), and elevated peripheral blood eosinophil counts (P = 0.022). Smith and Bhalla scores were shown to correlate positively with NPs and negatively with FEV1% predicted and body mass index. Cutoff values of FEV1% predicted ≤ 71.40%, peripheral blood eosinophil counts > 0.60 × 109/L, presence of NPs, and ≥ 1 severe exacerbation of asthma in the last 12 months were shown to differentiate bronchiectasis in asthma-CRS patients. Conclusions Bronchiectasis commonly overlaps in asthma-CRS patients. The coexistence of bronchiectasis predicts a more severe disease subset in terms of asthma and CRS. We suggest that asthma-CRS patients with NPs, severe airflow obstruction, eosinophilic inflammation, and poor asthma control should receive HRCT for the early diagnosis of bronchiectasis.

scholarly journals Coronavirus disease 2019 and peripheral blood eosinophil counts: a retrospective study

Infection ◽  
2021 ◽  
Author(s):  
Marjella Eijmael ◽  
Nicky Janssens ◽  
Saskia le Cessie ◽  
Yordi van Dooren ◽  
Ted Koster ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Medical Records ◽  
Clinical Severity ◽  
Blood Eosinophil ◽  
Chain Reaction ◽  
Peripheral Blood Eosinophil ◽  
Laboratory Results ◽  
The Mean ◽  
Polymerase Chain ◽  
Eosinophil Counts

Abstract Purpose Eosinopenia has been described in COVID-19. With this study, we aim to study the peripheral blood eosinophil counts in COVID-19 patients and to investigate whether there is an association between the peripheral blood eosinophil counts and disease severity of COVID-19. Methods We revised the electronical medical records of confirmed COVID-19 patients with polymerase chain reaction (PCR) assays in the Groene Hart Ziekenhuis, Gouda, The Netherlands. We divided patients in mild, moderate and severe groups based on clinical severity of COVID-19. Clinical severity was based on the therapy needed and the outcome of patients. We compared clinical characteristics, laboratory results and outcome between the three groups. Results Of the 230 patients included in this study, the mild, moderate and severe groups consisted of 16.5%, 45.7% and 37.8% of the included patients, respectively. The mean age was 68 years (IQR 57–78). 63% of patients were male. A significant decrease in the peripheral eosinophil counts was found corresponding to the increase of COVID-19 severity. In the mild, moderate and severe groups, the percentage of patients with eosinopenia was 73.7%, 86.7% and 94.3%, respectively (p value 0.002). Conclusion Eosinopenia is significantly more frequent present in patients with a severe COVID-19.

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