scholarly journals Combination Cancer Immunotherapy with Molecular Targeted Agents/Anti-CTLA-4 Antibody for Hepatocellular Carcinoma

Liver Cancer ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Masatoshi Kudo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Immunotherapy ◽  
Targeted Agents ◽  
Molecular Targeted Agents

scholarly journals MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Bin Yang ◽  
Chunping Wang ◽  
Hui Xie ◽  
Yiwu Wang ◽  
Jiagan Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Notch Signaling Pathway ◽  
Advanced Hepatocellular Carcinoma ◽  
Targeted Agents ◽  
Mesenchymal Transition ◽  
Molecular Targeted Agents ◽  
Hcc Cells

Abstract Molecular targeted agents, such as sorafenib, remain the only choice of an antitumor drug for the treatment of advanced hepatocellular carcinoma (HCC). The Notch signaling pathway plays central roles in regulating the cellular injury/stress response, anti-apoptosis, or epithelial–mesenchymal transition process in HCC cells, and is a promising target for enhancing the sensitivity of HCC cells to antitumor agents. The ADAM metalloprotease domain-17 (ADAM-17) mediates the cleavage and activation of Notch protein. In the present study, microRNA-3163 (miR-3163), which binds to the 3′-untranslated region of ADAM-17, was screened using online methods. miRDB and pre-miR-3163 sequences were prepared into lentivirus particles to infect HCC cells. miR-3163 targeted ADAM-17 and inhibited the activation of the Notch signaling pathway. Infection of HCC cells with miR-3163 enhanced their sensitivity to molecular targeted agents, such as sorafenib. Therefore, miR-3163 may contribute to the development of more effective strategies for the treatment of advanced HCC.

scholarly journals Molecular targeted agents as second-line treatment for hepatocellular carcinoma: a meta-analysis and review

Oncotarget ◽  
2017 ◽  
Vol 8 (60) ◽  
pp. 102321-102327 ◽  
Author(s):  
Jung Han Kim ◽  
Bum Jun Kim ◽  
Hyun Joo Jang ◽  
Jin Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Meta Analysis ◽  
Line Treatment ◽  
Second Line ◽  
Targeted Agents ◽  
Molecular Targeted Agents

scholarly journals Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma

In Vivo ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 1185-1189
Author(s):  
NORITAKA MATSUDA ◽  
NORIHIRO IMAI ◽  
TEIJI KUZUYA ◽  
KENTA YAMAMOTO ◽  
TAKANORI ITO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Targeted Agents ◽  
Molecular Targeted Agents

scholarly journals Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α

2021 ◽  
Vol 11 ◽  
Author(s):  
Juan Liu ◽  
Chao Yang ◽  
Xiao-Mei Huang ◽  
Pan-Pan Lv ◽  
Ya-Kun Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Warburg Effect ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Targeted Agents ◽  
Related Factors ◽  
Mesenchymal Transition ◽  
Molecular Targeted Agents ◽  
Hcc Cells ◽  
The Warburg Effect

The transcription suppressor factor FBI-1 (the factor that binds to inducer of short transcripts-1) is an important regulator of hepatocellular carcinoma (HCC). In this work, the results showed that FBI-1 promoted the Warburg effect and enhances the resistance of hepatocellular carcinoma cells to molecular targeted agents. Knockdown of FBI-1 via its small-interfering RNA (siRNA) inhibited the ATP level, lactate productions, glucose uptake or lactate dehydrogenase (LDH) activation of HCC cells. Transfection of siFBI-1 also decreased the expression of the Warburg-effect-related factors: hypoxia-inducible factor-1 alpha (HIF-1α), lactate dehydrogenase A (LDHA), or GLUT1, and the epithelial–mesenchymal transition-related factors, Vimentin or N-cadherin. The positive correlation between the expression of FBI-1 with HIF-1α, LDHA, or GLUT1 was confirmed in HCC tissues. Mechanistically, the miR-30c repressed the expression of HIF-1α by binding to the 3′-untranslated region (3′-UTR) of HIF-1α in a sequence-specific manner, and FBI-1 enhanced the expression of HIF-1α and HIF-1α pathway’s activation by repressing the expression of miR. By modulating the miR-30c/HIF-1α, FBI-1 promoted the Warburg effect or the epithelial–mesenchymal transition of HCC cells and promoted the resistance of HCC cells to molecular targeted agents.

Abstract 1469: Radiosensitization of hepatocellular carcinoma using rationally combined molecular-targeted agents

2012 ◽  
Author(s):  
Aaron T. Wild ◽  
Amy Hacker-Prietz ◽  
Hubert D. Daniel ◽  
Anirban Maitra ◽  
Michael S. Torbenson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Agents ◽  
Molecular Targeted Agents
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