Inspiratory and Expiratory Flow Changes, Voice Symptoms and Laryngeal Findings during Histamine Challenge Tests

2019 ◽  
Vol 72 (1) ◽  
pp. 29-35
Author(s):  
Maaria Ansaranta ◽  
Paula Kauppi ◽  
Leo Pekka Malmberg ◽  
Erkki Vilkman ◽  
Ahmed Geneid
Keyword(s):  
Challenge Tests ◽  
Flow Changes ◽  
Expiratory Flow ◽  
Voice Symptoms ◽  
Histamine Challenge

Forced expiration: a test for airflow obstruction in horses

2000 ◽  
Vol 88 (5) ◽  
pp. 1870-1879 ◽  
Author(s):  
Laurent L. Couëtil ◽  
Frank S. Rosenthal ◽  
Chris M. Simpson
Keyword(s):  
Airway Obstruction ◽  
Airflow Obstruction ◽  
Lung Mechanics ◽  
Normal Lung ◽  
Chronic Obstructive ◽  
Forced Expiration ◽  
Obstructive Pulmonary Disease ◽  
Forced Expiratory Flow ◽  
Expiratory Flow ◽  
Histamine Challenge

The purpose of this study was to assess whether our method of inducing forced expiration detects small airway obstruction in horses. Parameters derived from forced expiratory flow-volume (FEFV) curves were compared with lung mechanics data obtained during spontaneous breathing in nine healthy horses, in three after histamine challenge, and in two with chronic obstructive pulmonary disease (COPD) pre- and posttherapy with prednisone. Parameters measured in the healthy horses included forced vital capacity (FVC = 41.6 ± 5.8 liters; means ± SD) and forced expiratory flow (FEF) at various percentages of FVC (range of 20.4–29.7 l/s). Histamine challenge induced a dose-dependent decrease in FVC and FEF at low lung volume. After therapy, lung function of the two COPD horses improved to a point where one horse had normal lung mechanics during tidal breathing; however, FEF at 95% of FVC (4.9 l/s) was still decreased. We concluded that FEFV curve analysis allowed the detection of induced or naturally occurring airway obstruction.

Maximum expiratory flow changes induced by longitudinal tension on trachea in normal subjects

1977 ◽  
Vol 43 (3) ◽  
pp. 537-544 ◽  
Author(s):  
C. G. Melissinos ◽  
J. Mead
Keyword(s):  
Normal Subjects ◽  
Lung Volumes ◽  
Maximal Expiratory Flow ◽  
Maximum Expiratory Flow ◽  
Flow Changes ◽  
Longitudinal Tension ◽  
Expiratory Flow ◽  
Young Subjects ◽  
Tube Wave ◽  
Configuration Changes

Maximal expiratory flow (Vmax) was noticed to increase in some subjects during neck hypertension. Maximal expiratory flow volume (MEFV) curves were obtained in 15 normal young subjects at regular and hyperextended neck posture. Eleven of the subjects had consistently higher Vmax during neck hyperextension at high lung volumes, accompanied by MEFV configuration changes in the form of the obliteration of a concavity towards the volume axis that existed in the curve at regular neck posture. Effort independency was documented at lung volumes where the changes occurred. Radiographic studies indicate tracheal elongation with a relatively fixed carina during neck hyperextension. We propose that at high lung volumes in normal young subjects, the flow-limiting mechanism resides in the trachea and that the increased Vmax with neck hyperextension. We propose that at high lung volumes in normal young subjects, the flow-limiting mechanism resides in the trachea and that the increased Vmax with neck hyperextension reflects the effect of tracheal elongation which stiffens the trachea under dynamic conditions and increases its tube-wave speed. This concept was confirmed by MEFV curves obtained from anesthetized tracheostomized dogs when increased tracheal longitudinal tension resulted in an increase of Vmax.

Refractoriness for ultrasonically nebulized distilled water and histamine after histamine challenge

1991 ◽  
Vol 70 (3) ◽  
pp. 1011-1015 ◽  
Author(s):  
C. Groot ◽  
J. W. Lammers ◽  
J. Festen ◽  
C. van Herwaarden
Keyword(s):  
Cumulative Dose ◽  
Bronchial Hyperresponsiveness ◽  
Distilled Water ◽  
Asthmatic Patients ◽  
Challenge Tests ◽  
The Mean ◽  
Bronchial Provocation ◽  
Histamine Challenge

Refractoriness for bronchial provocation frequently occurs after different challenge tests used to assess bronchial hyperresponsiveness in asthmatic patients. We investigated whether histamine inhalation could cause refractoriness for bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) and whether histamine causes tachyphylaxis for a subsequent histamine challenge in nine stable asthmatic patients. Preinhalation of histamine induced a significant diminished bronchoconstrictor response to UNDW cumulative dose of inhaled UNDW causing a 20% fall in forced expired volume in 1 s. The mean increased from 3.5 +/- 0.8 to 11.8 +/- 2.6 (SE) ml after histamine challenge (P less than 0.01). However, repeated inhalation of histamine did not change the bronchoconstrictor response to histamine within 1 h after rechallenge (P greater than 0.5). The magnitude of refractoriness for UNDW inhalation after preinhalation of histamine was correlated to the bronchoconstrictor response to histamine (r = 0.73, P less than 0.05). We conclude that inhaled histamine can induce refractoriness for UNDW, which seems to be related to the degree of bronchial hyperresponsiveness.

scholarly journals Reproducibility of histamine challenge tests in asthmatic children.

Thorax ◽  
1983 ◽  
Vol 38 (4) ◽  
pp. 258-260 ◽  
Author(s):  
D Hariparsad ◽  
N Wilson ◽  
C Dixon ◽  
M Silverman
Keyword(s):  
Asthmatic Children ◽  
Challenge Tests ◽  
Histamine Challenge

Development of increased airway responsiveness in two nurses performing methacholine and histamine challenge tests

Allergy ◽  
1992 ◽  
Vol 47 (2) ◽  
pp. 188-189 ◽  
Author(s):  
R. Lundgren ◽  
M. Söderberg ◽  
L. Rosenhall ◽  
E. Norrman
Keyword(s):  
Airway Responsiveness ◽  
Challenge Tests ◽  
Histamine Challenge

scholarly journals Cross-shift peak expiratory flow changes are unassociated with respirable coal dust exposure among South African coal miners

2007 ◽  
Vol 50 (12) ◽  
pp. 992-998
Author(s):  
Rajen N. Naidoo ◽  
Thomas G. Robins ◽  
Margaret Becklake ◽  
Noah Seixas ◽  
Mary Lou Thompson
Keyword(s):  
South African ◽  
Peak Expiratory Flow ◽  
Coal Dust ◽  
Dust Exposure ◽  
Coal Miners ◽  
Flow Changes ◽  
Expiratory Flow

scholarly journals Peak expiratory flow changes during experimental rhinovirus infection

2000 ◽  
Vol 16 (5) ◽  
pp. 980-985 ◽  
Author(s):  
P.G. Bardin ◽  
D.J. Fraenkel ◽  
G. Sanderson ◽  
E.M. van Schalkwyk ◽  
S.T. Holgate ◽  
...  
Keyword(s):  
Peak Expiratory Flow ◽  
Rhinovirus Infection ◽  
Flow Changes ◽  
Expiratory Flow

No effect of artificial gravity on lung function with exercise training during head-down bed rest

2015 ◽  
pp. 1-7
Author(s):  
Longxiang Su ◽  
Yinghua Guo ◽  
Yajuan Wang ◽  
Delong Wang ◽  
Changting Liu
Keyword(s):  
Lung Function ◽  
Pulse Rate ◽  
Vital Capacity ◽  
Pulmonary Ventilation ◽  
Bed Rest ◽  
Forced Expiratory Volume ◽  
Observation Time ◽  
Artificial Gravity ◽  
Postural Changes ◽  
Expiratory Flow

AbstractTo explore the effectiveness of microgravity simulated by head-down bed rest (HDBR) and artificial gravity (AG) with exercise on lung function. Twenty-four volunteers were randomly divided into control and exercise countermeasure (CM) groups for 96 h of 6° HDBR. Comparisons of pulse rate, pulse oxygen saturation (SpO2) and lung function were made between these two groups at 0, 24, 48, 72, 96 h. Compared with the sitting position, inspiratory capacity and respiratory reserve volume were significantly higher than before HDBR (0° position) (P< 0.05). Vital capacity, expiratory reserve volume, forced vital capacity, forced expiratory volume in 1 s, forced inspiratory vital capacity, forced inspiratory volume in 1 s, forced expiratory flow at 25, 50 and 75%, maximal mid-expiratory flow and peak expiratory flow were all significantly lower than those before HDBR (P< 0.05). Neither control nor CM groups showed significant differences in the pulse rate, SpO2, pulmonary volume and pulmonary ventilation function over the HDBR observation time. Postural changes can lead to variation in lung volume and ventilation function, but a HDBR model induced no changes in pulmonary function and therefore should not be used to study AG CMs.

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