Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder

Anton Schulmann; Euijung Ryu; Vanessa Goncalves; Brandi Rollins; Michael Christiansen; Mark A. Frye; Joanna  Biernacka; Marquis P. Vawter

doi:10.1159/000495658

Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder

Molecular Neuropsychiatry ◽

10.1159/000495658 ◽

2019 ◽

Vol 5 (1) ◽

pp. 13-27 ◽

Cited By ~ 15

Author(s):

Anton Schulmann ◽

Euijung Ryu ◽

Vanessa Goncalves ◽

Brandi Rollins ◽

Michael Christiansen ◽

...

Keyword(s):

Bipolar Disorder ◽

Nuclear Dna ◽

Complex Interactions ◽

Novel Complex

Download Full-text

F90NOVEL COMPLEX INTERACTIONS BETWEEN MITOCHONDRIAL AND NUCLEAR DNA IN SCHIZOPHRENIA AND BIPOLAR DISORDER

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2018.08.170 ◽

2019 ◽

Vol 29 ◽

pp. S1158

Author(s):

Marquis Vawter ◽

Euijung Ryu ◽

Vanessa F. Goncalves ◽

Joanna Biernacka ◽

Mark Frye ◽

...

Keyword(s):

Bipolar Disorder ◽

Nuclear Dna ◽

Complex Interactions

Download Full-text

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

BioMed Research International ◽

10.1155/2014/560340 ◽

2014 ◽

Vol 2014 ◽

pp. 1-14 ◽

Cited By ~ 12

Author(s):

Paolo Garagnani ◽

Chiara Pirazzini ◽

Cristina Giuliani ◽

Marco Candela ◽

Patrizia Brigidi ◽

...

Keyword(s):

Mitochondrial Dna ◽

Nuclear Dna ◽

Complex Dynamics ◽

Nuclear Genome ◽

Holistic Approach ◽

Human Longevity ◽

Human Lifespan ◽

Complex Interactions ◽

Age Related

Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and number of genes encoded, plays a major role in the ageing process. The complex interplay between nDNA/mtDNA and the environment is most likely involved in phenomena such as ageing and longevity. To this scenario we have to add another level of complexity represented by the microbiota, that is, the whole set of bacteria present in the different part of our body with their whole set of genes. In particular, several studies investigated the role of gut microbiota (GM) modifications in ageing and longevity and an age-related GM signature was found. In this view, human being must be considered as “metaorganism” and a more holistic approach is necessary to grasp the complex dynamics of the interaction between the environment and nDNA-mtDNA-GM of the host during ageing. In this review, the relationship between the three genetics and human longevity is addressed to point out that a comprehensive view will allow the researchers to properly address the complex interactions that occur during human lifespan.

Download Full-text

Where’s the fat? Freeze-fracture analysis of ingredient interactions in food systems

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100146084 ◽

1993 ◽

Vol 51 ◽

pp. 48-49

Author(s):

Jean Fincher

Keyword(s):

Lipid Droplets ◽

Food Systems ◽

Food Industry ◽

Freeze Fracture ◽

Food Science ◽

Complex Interactions ◽

Fat Reduction ◽

Important Trend ◽

Conventional Foods ◽

Whipped Cream

An important trend in the food industry today is reduction in the amount of fat in manufactured foods. Often fat reduction is accomplished by replacing part of the natural fat with carbohydrates which serve to bind water and increase viscosity. It is in understanding the roles of these two major components of food, fats and carbohydrates, that freeze-fracture is so important. It is well known that conventional fixation procedures are inadequate for many food products, in particular, foods with carbohydrates as a predominant structural feature. For some food science applications the advantages of freeze-fracture preparation procedures include not only the avoidance of chemical fixatives, but also the opportunity to control the temperature of the sample just prior to rapid freezing.In conventional foods freeze-fracture has been used most successfully in analysis of milk and milk products. Milk gels depend on interactions between lipid droplets and proteins. Whipped emulsions, either whipped cream or ice cream, involve complex interactions between lipid, protein, air cell surfaces, and added emulsifiers.

Download Full-text