scholarly journals Pulse Granulomas in Interval Appendectomy Specimens: Histochemical Identification of Cellulose Matter

2018 ◽  
Vol 12 (3) ◽  
pp. 765-772 ◽  
Author(s):  
Shinichi Ban ◽  
Akiko Fujii ◽  
Toshiro Takimoto ◽  
Kenta Kikuchi ◽  
Woodea Kang ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Foreign Bodies ◽  
Polarized Light ◽  
Amyloid Deposition ◽  
Vascular Lesions ◽  
Interval Appendectomy ◽  
Foreign Materials ◽  
Histopathologic Findings ◽  
Histochemical Identification ◽  
Sirius Red

Pulse granuloma is a rare pathologic condition considered to be a benign inflammatory reaction to foreign materials originated from ingested legume matter. As for pulse granulomas of the gastrointestinal tract, association with diverticular diseases is relatively common, but only a few pulse granuloma cases associated with appendicitis have been reported. This report presents histopathologic findings of pulse granuloma lesions observed in two appendectomy cases, with some histochemical examinations of cellulose matter which is reportedly a major component to provoke pulse granuloma reaction. Our patients in both cases were girls in their teens, and they underwent interval appendectomy for acute appendicitis. Both appendectomy specimens revealed ruptured walls with inflammatory granulation tissue with marked foreign body reaction including characteristic collections of ring-like, curled ribbon-like, and/or lobulated nephrosclerosis-like hyaline structures and various foreign bodies, in which microorganisms or amyloid deposition were not identified. The presence of cellulose matter was suggested by Sirius red stain, the IKI (iodine potassium iodide)-H2SO4 method, and birefringence by polarized light. Appendectomy materials due to acute appendicitis would include pulse granuloma reaction provoked by ingested materials with cellulose. Pathologists should be familiar with the concept and histopathologic features of pulse granulomas to avoid misinterpreting them as vascular lesions and/or amyloid deposition, or any infectious organisms.

scholarly journals Antibiotics in acute appendicitis. When and how? A general review

2019 ◽  
Vol 6 (1) ◽  
pp. 30-33
Author(s):  
L. Alecu ◽  
C. Niţipir ◽  
Iulian Slavu ◽  
V. Braga ◽  
D. Mihăilă ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Antibiotic Treatment ◽  
Complication Rate ◽  
Acquired Resistance ◽  
Perforated Appendicitis ◽  
Interval Appendectomy ◽  
Bacterial Proliferation ◽  
Long Period ◽  
Clinical Surveillance ◽  
Relapse Rates

Introduction: An increasing interest exits towards the use of antibiotics in the treatment of uncomplicated acute appendicitis.Discussion: For a long period of time, surgery was the only treatment for acute appendicitis. Due to recent research in the etiology of acute appendicitis which seems to be driven by intraluminal bacterial proliferation, new data suggests that for non-perforated appendicitis confirmed with the help of CT, antibiotics may play a central role in the treatment. As relapse rates amount in some cases to only 5% after antibiotic treament, a discussion is required regarding the risks of interval appendectomy and its use. The debate regarding the optimal antibiotic course is on-going as some surgeons advocate for amoxicillin/clavulanic while others, due to acquired resistance recommend Ertapenem.Conclusion:  Selective antibiotic treatment for selected forms of acute appendicitis, uncomplicated without perforation is safe and has a relatively low complication rate. However, certain mentions must be made:  surgery must not be delayed if failure of antibiotics exists as it can lead to higher rates of peritonitis. Close clinical surveillance is of utmost importance

scholarly journals Pyogenic Granuloma: A Case Report

1970 ◽  
Vol 8 (3) ◽  
pp. 196-198 ◽  
Author(s):  
Md T Rizwanulla ◽  
Bandana Koirala ◽  
Shivalal Sharma ◽  
Lalita Adhikari ◽  
Anju Pradhan
Keyword(s):  
Case Report ◽  
Inflammatory Response ◽  
Pyogenic Granuloma ◽  
Capillary Hemangioma ◽  
Definitive Diagnosis ◽  
Vascular Lesions ◽  
Minor Trauma ◽  
Lobular Capillary Hemangioma ◽  
Dental Restorations ◽  
Foreign Materials

Anju Pradhan was added as an author of this paper on 04/03/2011Pyogenic granulomas (PG) are common benign vascular lesions of the skin and mucosa. They are neither infective, purulent nor granulomatous as the name might suggest-rather a reactive enlargement that is an inflammatory response to local irritation such as calculus, fractured tooth, minor trauma, rough dental restorations and foreign materials. Here, we report a case of 13 year old patient with PG and in addition to the knowledge, the importance of biopsy findings in establishing definitive diagnosis has been emphasized. Keywords: pyogenic granuloma; inflammatory hyperplasia; lobular capillary hemangioma. DOI: 10.3126/hren.v8i3.4215Health Renaissance, September-December 2010; Vol 8 (No.3);196-198

Acute appendicitis caused by foreign bodies

1932 ◽  
Vol 17 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Karl A. Meyer ◽  
Peter A. Rosi
Keyword(s):  
Acute Appendicitis ◽  
Foreign Bodies

scholarly journals Analysis of Colorectal Carcinogenesis Paradigm between Cold Constitution and Heat Constitution: Earlier ECM Collagen Deposition

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Feifei Nong ◽  
Yuqi Liang ◽  
Shangping Xing ◽  
Huixuan Li ◽  
Xizheng Lin ◽  
...  
Keyword(s):  
Lysyl Oxidase ◽  
Critical Role ◽  
Polarized Light ◽  
Malignant Progression ◽  
Colorectal Carcinogenesis ◽  
Mrna Levels ◽  
Collagen Deposition ◽  
Colon Tissue ◽  
Qrt Pcr ◽  
Sirius Red

Colorectal cancer (CRC) is a common malignant tumor around the world. Studying the unique constitution of CRC patients is conducive to the application of personalized medical treatment for CRC. The most common types of constitution in CRC are cold and heat constitution. A previous study has suggested that the malignant progression in cold and heat constitution CRC are different; however, the mechanism remains unclear. The tumor microenvironment (TME) is likely to vary with each individual constitution, which may affect the tumor growth in different constitutions. The extracellular matrix (ECM), the most important component of TME, plays a critical role in disease progression and outcome in patients with CRC. Moreover, collagen, the major component of the ECM, determines the main functional characteristics of ECM and tissue fibrosis caused by collagen deposition, which is one of the signs of CRC malignant progression. This study aimed to explore the mechanisms leading to different colorectal carcinogenesis paradigms between the cold constitution and heat constitution within the context of ECM collagen deposition. We established the CRC rat models and enrolled 30 CRC patients with cold and heat constitution. The collagen-related parameters were detected by using Sirius red staining combined with polarized light microscope, and expressions of collagen (COL I and COL III) and lysyl oxidase (LOX and LOXL2) were determined using immunohistochemistry, while the mRNA levels of COL1A1, COL3A1, LOX, and LOXL2 were measured by qRT-PCR. We found that a higher degree of collagen deposition in the cold-constitution group. The results suggest cold and heat constitution may affect the colorectal carcinogenesis paradigm by influencing the early collagen deposition in colon tissue. The study may provide an effective idea for clinicians to improve the prognosis of CRC patients with different constitutions.

scholarly journals Amyloid Deposition Within a Large Pelvic Chronic Expanding Hematoma

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S66-S66
Author(s):  
D M Montoya-Cerrillo ◽  
J A Diaz-Perez ◽  
A E Rosenberg
Keyword(s):  
Past History ◽  
Rare Complication ◽  
Polarized Light ◽  
Outlet Obstruction ◽  
Amyloid Deposition ◽  
Systemic Amyloidosis ◽  
Pelvic Cavity ◽  
Amyloid Protein ◽  
Soft Tissue Neoplasm ◽  
Chronic Expanding Hematoma

Abstract Introduction/Objective Chronic expanding hematoma (CEH) is a relatively rare complication of trauma that is usually mistaken for a soft tissue neoplasm. The identification of amyloid protein is of paramount clinical importance to exclude serious conditions causing systemic amyloidosis. Methods The case was retrieved from the pathology files at the University of Miami Hospital (UMH). Morphology and special stains were reviewed. The study was approved by the Institutional Review Board at UMH. Results A 44-year-old man with past history of a stab wound in the left buttock in the 1990s, was admitted with worsening abdominal pain, constipation, urinary obstruction and acute kidney injury. CT-scan showed a large mass involving the left gluteal area and pelvic cavity involving urinary bladder causing outlet obstruction and bilateral hydroureteronephrosis. Multiple radiology-guided biopsies were taken all identifying only fibrin, blood cells, and necrotic inflammatory cells. Excision of the gluteal mass and drainage of the pelvic component was performed confirming the diagnosis of CEH. Amyloid deposition with congo red stain birefringence under polarized light was identified. The patient’s symptoms and renal function improved and have been under follow-up for 1 month. Conclusion We have identified amyloid protein deposition whiting a CEH. This is an unusual finding with no previous description found in our search. The identification of amyloid whiting tumor-like lesions is relevant to exclude causes of systemic amyloidosis.

Clinical Outcomes for Interval Appendectomy in the Treatment of Acute Appendicitis With an Appendiceal Abscess or Mass

2015 ◽  
Vol 110 ◽  
pp. S560
Author(s):  
Hiromitsu Kinoshita ◽  
Masato Kondo ◽  
Shoichi Kitano ◽  
Yukiko Kumata ◽  
Ryosuke Kita ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Clinical Outcomes ◽  
Interval Appendectomy ◽  
Appendiceal Abscess

scholarly journals Impression Material Mass Retained in the Mucobuccal Fold

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
N. Karam Genno ◽  
A. Assaf
Keyword(s):  
Foreign Body ◽  
Oral Cavity ◽  
Case History ◽  
Foreign Bodies ◽  
Dental Materials ◽  
Spectrometric Analysis ◽  
Mucosal Tissue ◽  
Impression Material ◽  
Foreign Materials ◽  
Tissue Reactions

Trapped foreign bodies and tissue reactions to foreign materials are commonly encountered in the oral cavity. Traumatically introduced dental materials, instruments, or needles are the most common materials referred to in the dental literature. This paper describes an iatrogenic foreign body encapsulation in the oral mucosa, clinically appearing as5×10 mm tumor-like swelling with an intact overlying epithelium and diagnosed as a polymeric impression material. Detailed case history and, clinical and radiographic examinations including CBCT and spectrometric analysis of the retrieved sample were necessary to determine accurately the nature, size, and location of the foreign body. It is suggested that the origin of the material relates to an impression made 2 years ago, leaving a mass trapped in a traumatized mucosal tissue.

scholarly journals Fatal pulmonary hemorrhage associated with vascular amyloid deposition in a cat

2018 ◽  
Vol 4 (2) ◽  
pp. 205511691881799
Author(s):  
Dianne I Mawby ◽  
Jacqueline C Whittemore ◽  
Robert L Donnell
Keyword(s):  
Complete Blood Count ◽  
Polarized Light ◽  
Pulmonary Hemorrhage ◽  
Coagulation Factor ◽  
Amyloid Deposition ◽  
Pulmonary Vasculature ◽  
Lymphoid Tissues ◽  
Initial Onset ◽  
Congo Red Staining ◽  
Pulmonary Amyloidosis

Case summary An adult female spayed Siamese-cross cat of unknown age was presented for bilateral hemorrhagic otorrhea. Nasopharyngeal polyps were diagnosed by CT and biopsy; bilateral ventral bulla osteotomies were performed. Episodic epistaxis, otic hemorrhage and hemoptysis with respiratory distress progressed over 18 months. Systolic blood pressure, complete blood count, plasma biochemistries, prothrombin time, partial thromboplastin time and coagulation factor 12, 9 and 8 activities were normal. Serial thoracic radiographs revealed patchy interstitial to alveolar patterns. Airway hemorrhage prevented diagnostic bronchoscopy. Respiratory hemorrhage was ultimately fatal. Amyloid deposition was identified in pulmonary vasculature, bronchial wall, lymphoid tissues, nasal-pharyngeal tissue and tympanic bullae based on microscopic examination and confirmed by Congo red staining with green birefringence under polarized light. Relevance and novel information Amyloidosis should be considered as a differential diagnosis in cats with spontaneous hemorrhage of the respiratory or otic tracts. Although systemic amyloidosis is associated with a grave prognosis, this case suggests that prolonged survival is possible after the initial onset of signs in cats with pulmonary amyloidosis.

scholarly journals Tu1575 Conservative Treatment and Interval Appendectomy for Acute Appendicitis

2014 ◽  
Vol 146 (5) ◽  
pp. S-1079
Author(s):  
Toshiyuki Moriya ◽  
Kenji Mase ◽  
Koichiro Ozawa ◽  
Shigeo Hasegawa ◽  
Masaomi Mizutani ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Acute Appendicitis ◽  
Interval Appendectomy

scholarly journals Routine Histopathologic Examination of Appendectomy Specimens: Retrospective Analysis of 1255 Patients

2013 ◽  
Vol 98 (4) ◽  
pp. 354-362 ◽  
Author(s):  
Arif Emre ◽  
Sami Akbulut ◽  
Zehra Bozdag ◽  
Mehmet Yilmaz ◽  
Murat Kanlioz ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Muscularis Propria ◽  
Parasite Infection ◽  
Initial Diagnosis ◽  
Carcinoid Tumors ◽  
Incidental Appendectomy ◽  
Histopathologic Analysis ◽  
Routine Histopathologic Examination ◽  
Age Range ◽  
Histopathologic Findings

Abstract The objective of this study was to analyze the clinical benefit of histopathologic analysis of appendectomy specimens from patients with an initial diagnosis of acute appendicitis. We retrospectively analyzed the demographic and histopathologic data of 1255 patients (712 males, 543 females; age range, 17–85 years) who underwent appendectomy to treat an initial diagnosis of acute appendicitis. Patients who underwent incidental appendectomy during other surgeries were excluded from the study. Histopathologic findings of the appendectomy specimens were used to confirm the initial diagnosis. Ninety-four percent of the appendectomy specimens were positive for appendicitis. Of those, 880 were phlegmonous appendicitis, 148 were gangrenous appendicitis with perforation, and the remaining 88 showed unusual histopathologic findings. In the 88 specimens with unusual pathology, fibrous obliteration was observed in 57 specimens, carcinoid tumor in 11, Encheliophis vermicularis parasite infection in 8, granulatomous inflammation in 6, appendiceal endometriosis in 2, and 1 specimen each showed mucocele, eosinophilic infiltration, Taenia saginata parasite infection, and appendicular diverticulitis. All carcinoid tumors were located in the distal appendix. Six of the 11 carcinoid tumors were defined by histopathology as involving tubular cells, and the other 5 as involving enterochromaffin cells. Six patients had muscularis propria invasion, 2 patients had submucosa invasion, 2 patients had mesoappendix invasion, and 1 patient had serosal invasion. All patients with tumors remained disease free during the follow-up (range, 1–27 months). We conclude that when the ratio of unusual pathologic findings for appendectomy specimens is considered, it is evident that all surgical specimens should be subjected to careful histologic examination.

Sign in / Sign up

Export Citation Format

Share Document