Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients

Nephron ◽  
2018 ◽  
Vol 141 (3) ◽  
pp. 156-165 ◽  
Author(s):  
Christian Albert ◽  
Johanna Kube ◽  
Annemarie Albert ◽  
Denny Schanze ◽  
Martin Zenker ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Nucleotide Polymorphism ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Flip Flop ◽  
Metalloproteinase 9 ◽  
Type 2 Diabetic

scholarly journals Prevalence of Early B-Cell Factor 1 Gene rs4704963 Single Nucleotide Polymorphism (T>C) in a Population of Type 2 Diabetic Patients with Obesity

2018 ◽  
Vol 86 (5) ◽  
pp. 310-316
Author(s):  
Mario B. Principato ◽  
Rocío Castilla ◽  
Alejandra Duarte ◽  
Julio C. Bragagnolo ◽  
Graciela Ortensi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
B Cell ◽  
Diabetic Patients ◽  
Nucleotide Polymorphism ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Early B Cell Factor ◽  
Type 2 Diabetic

Evaluation of urinary TNF-α and KIM-1 biomarkers in T2DM in Upper Egypt

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy EL Sharkawy ◽  
Samir K Abdul-Hamid ◽  
Tarek T Elmelegy ◽  
Mohammed F Adawy
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Clinical Syndrome ◽  
Diabetic Patients ◽  
University Hospitals ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Tnf Α ◽  
Type 2 Diabetic

Abstract Background Diabetes mellitus (DM) is the most frequent cause of chronic kidney failure in both developed and developing countries. Diabetic nephropathy, is a clinical syndrome characterized by albuminuria (>300 mg/day) with permanent and irreversible decrease in glomerular filtration rate (GFR). Aim of the Work To study the role of urinary TNF-α and urine KIM-1 in type 2 diabetic patients as predictors of DN comparative with albuminuria. Patients and Methods This is a cross-sectional study which include 90 type-2 diabetic patients and 30 controls selected from the outpatient clinic of Assiut University hospitals. All patients gave an informed consent and approval for the study was obtained from the IRB committee of the Assiut Medical Faculty. The recruited patients were divided into three groups: Normo-albuminuria Group (A) (n = 30): UACR less than 30 mg/gm, Microalbuminuria Group (B) (n = 30): UACR between 30-299 mg/gm and Macro-albuminuria Group (C) (n = 30): UACR equal or more than 300 mg/gm. Assess Urinary TNF-α and urine KIM-1 in comparision with albuminuria. Results Urinary KIM-1 and urinary TNF-α are statically significant with albuminuria in patients in the early stage of diabetic nephropathy (eGFR _60 mL/min/1.73 m2).Also there are statically significance between patients with macroalbuminuria than microalbuminuria. Conclusion The results of this study recommend the use of KIM-1 and TNF-α as good predictors of early detection of development of diabetic nephropathy.

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