scholarly journals Redesigning Skin Cancer Early Detection and Care Using a New Mobile Health Application: Protocol of the SKIN Research Project, a Randomised Controlled Trial

Dermatology ◽  
2018 ◽  
Vol 235 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Monika Janda ◽  
Caitlin Horsham ◽  
Uyen Koh ◽  
Nicole Gillespie ◽  
Lois J. Loescher ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Early Detection ◽  
Controlled Trial ◽  
Skin Lesions ◽  
Mobile Technologies ◽  
Whole Body ◽  
Naked Eye ◽  
Cancer Early Detection ◽  
Reported Data ◽  
Randomised Controlled

Patients often detect melanoma themselves; therefore, regular skin self-examinations (SSEs) play an important role in the early detection and prompt treatment of melanoma. Mobile teledermoscopy is a technology that may facilitate consumer SSEs and rapid communication with a dermatologist. This paper describes the planned randomised controlled trial of an intervention to determine whether mobile technologies can help improve the precision of SSE in consumers. A randomised controlled trial will be conducted to evaluate mobile teledermoscopy-enhanced SSE versus naked-eye SSE. Participants in each group will conduct three home whole-body SSEs at baseline, 1 and 2 months, then present for a clinical skin examination (CSE) by a doctor after the 2-month SSE. Specifically, participants will identify skin lesions that meet the AC (asymmetry and colour) rule for detecting a suspicious skin spot. The primary outcomes are sensitivity and specificity of the skin lesions selected by the participants as needing attention by a doctor, compared to the clinical diagnosis by the dermatologist that will serve as the reference standard for this analysis. For the mobile teledermoscopy-enhanced SSE group, researchers will assess the number, location and type of lesions (1) sent by the participant via mobile teledermoscopy, (2) found at CSE or (3) missed by the participant. For the naked-eye SSE group, researchers will assess the number, location and type of lesions (1) recorded on their body chart by the participant, (2) found at CSE or (3) missed by the participant. Secondary outcomes are based on participants’ self-reported data via online questionnaires.

scholarly journals The improvement of cognitive deficits after whole-body cryotherapy – A randomised controlled trial

2021 ◽  
Vol 146 ◽  
pp. 111237
Author(s):  
Joanna Rymaszewska ◽  
Katarzyna M. Lion ◽  
Bartłomiej Stańczykiewicz ◽  
Julia E. Rymaszewska ◽  
Elżbieta Trypka ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Cognitive Deficits ◽  
Controlled Trial ◽  
Whole Body ◽  
Randomised Controlled ◽  
Whole Body Cryotherapy

scholarly journals Protocol of a randomised controlled trial assessing the impact of physical activity on bone health in children with inflammatory bowel disease

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e036400
Author(s):  
Jérémy Vanhelst ◽  
Stéphanie Coopman ◽  
Julien Labreuche ◽  
Claire Dupont ◽  
Valérie Bertrand ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Randomised Controlled Trial ◽  
Bone Health ◽  
Bowel Disease ◽  
Controlled Trial ◽  
Whole Body ◽  
Paediatric Patients ◽  
Inflammatory Bowel ◽  
Randomised Controlled

IntroductionLow bone mineral density (BMD) is a frequent issue in children and adolescents with inflammatory bowel disease (IBD). Several studies in healthy populations have reported a positive impact of physical activity (PA) on bone health. Recently, an observational study in paediatric patients with IBD showed a significant positive relationship between daily PA and BMD. However, intervention studies investigating a causal relationship between PA and BMD are warranted to confirm these results. The aim of this randomised controlled trial will be to investigate the effect of a PA programme on BMD in paediatric patients with IBD.Methods and analysisThis trial is a multicentre (four centres), randomised, controlled, blinded end-point study. Eighty children with IBD will be randomly assigned in a 1:1 ratio to receive a programme with adapted physical exercises (intervention group) or usual PA (control group) during a 9-month period. The primary outcome is the change from baseline at 9 months (the end of the study) in whole-body BMD assessed by dual-energy X-ray absorptiometry. Secondary efficacy outcomes include the changes from baseline at 9 months in: BMD assessed in the lumbar spine and trochanter; daily PA (time spent in moderate-to-vigorous PA); body composition (fat mass and fat-free mass); fatigue resistance; quality of life and activity of IBD.Ethics and disseminationThe study was approved by the Research Ethics Committee in France (Comité de Protection des Personnes, Sud-Ouest and Outre-Mer III, Bordeaux, France, No 2018/27). All procedures will be performed according to the ethical standards of the Helsinki Declaration of 1975, as revised in 2008, and the European Union’s Guidelines for Good Clinical Practice. Written informed consent will be obtained from the parents or legal guardian and from the children. Research findings will be disseminated in peer-reviewed journals and scientific meetings.Trial registration numberNCT03774329.

Whole body FDG-PET in apparently-resectable NSCLC: Outline and design of the first randomised controlled trial of FDG-PET in NSCLC

Lung Cancer ◽  
2000 ◽  
Vol 29 (1) ◽  
pp. 253
Author(s):  
R Viney ◽  
M.J Fulham ◽  
B.C McCaughan ◽  
M.J Boyer ◽  
M King ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Fdg Pet ◽  
Controlled Trial ◽  
Whole Body ◽  
Randomised Controlled
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