scholarly journals Breakfast, Glycemic Index, and Cognitive Function in School Children: Evidence, Methods, and Mechanisms

Author(s):  
Sandra I. Sünram-Lea
Parasitology ◽  
1992 ◽  
Vol 104 (3) ◽  
pp. 539-547 ◽  
Author(s):  
C. Nokes ◽  
S. M. Grantham-McGregor ◽  
A. W. Sawyer ◽  
E. S. Cooper ◽  
B. A. Robinson ◽  
...  

A double-blind placebo trial was conducted to determine the effect of moderate to high loads ofTrichuris trichiura(whipworm) infection on the cognitive functions of 159 school children (age 9–12 years) in Jamaica. Infected children were randomly assigned to Treatment or Placebo groups. A third group of randomly selected uninfected children were assigned to a Control for comparative purposes. The improvement in cognitive function was evaluated using a stepwise multiple linear regression, designed to control for any confounding variables. The expulsion of worms led to a significant improvement in tests of auditory short-term memory (P< 0.02;P< 0.01), and a highly significant improvement in the scanning and retrieval of long-term memory (P< 0.001). After 9 weeks, treated children were no longer significantly different from an uninfected Control group in these three tests of cognitive function. The removal ofT. trichiurawas more important thanAscaris lumbricoidesin determining this improvement. The results suggest that whipworm infection has an adverse effect on certain cognitive functions which is reversible by therapy.


Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4246
Author(s):  
Sandra I. Sünram-Lea ◽  
Gertrude Gentile-Rapinett ◽  
Katherine Macé ◽  
Andreas Rytz

Reduced Glycemic Index (GI) of breakfast has been linked to improved cognitive performance in both children and adult populations across the morning. However, few studies have profiled the post-prandial glycemic response (PPGR) in younger children. The aim of this study was to assess PPGR to breakfast interventions differing in GI in healthy children aged 5–7 years. Eleven subjects completed an open-label, randomized, cross-over trial, receiving three equicaloric test beverages (260 kcal) consisting of 125 mL semi-skimmed milk and 50 g sugar (either glucose, sucrose, or isomaltulose). On a fourth occasion, the sucrose beverage was delivered as intermittent supply. PPGR was measured over 180 min using Continuous Glucose Monitoring (CGM). The incremental area under the curve (3h-iAUC) was highest for the glucose beverage, followed by intermittent sucrose (−21%, p = 0.288), sucrose (−27%, p = 0.139), and isomaltulose (−48%, p = 0.018). The isomaltulose beverage induced the smallest Cmax (7.8 mmol/L vs. >9.2 mmol/L for others) and the longest duration with moderate glucose level, between baseline value and 7.8 mmol/L (150 vs. <115 min for others). These results confirm that substituting mid-high GI sugars (e.g., sucrose and glucose) with low GI sugars (e.g., isomaltulose) during breakfast are a viable strategy for sustained energy release and glycemic response during the morning even in younger children.


2003 ◽  
Vol 133 (11) ◽  
pp. 3941S-3949S ◽  
Author(s):  
Charlotte G. Neumann ◽  
Nimrod O. Bwibo ◽  
Suzanne P. Murphy ◽  
Marian Sigman ◽  
Shannon Whaley ◽  
...  

2008 ◽  
Vol 101 (09) ◽  
pp. 1378 ◽  
Author(s):  
Constance A. Gewa ◽  
Robert E. Weiss ◽  
Nimrod O. Bwibo ◽  
Shannon Whaley ◽  
Marian Sigman ◽  
...  

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Chhavi Raj Bhatt ◽  
Geza Benke ◽  
Catherine L. Smith ◽  
Mary Redmayne ◽  
Christina Dimitriadis ◽  
...  

1996 ◽  
Vol 90 (1) ◽  
pp. 55-63 ◽  
Author(s):  
J. Meeks Gardner ◽  
S. Grantham-Mcgregor ◽  
A. Baddeley

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