scholarly journals Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options

2018 ◽  
Vol 9 (1) ◽  
pp. 8-21 ◽  
Author(s):  
Luca Di Lullo ◽  
Claudio Ronco ◽  
Antonio Granata ◽  
Ernesto Paoletti ◽  
Vincenzo Barbera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Medical Condition ◽  
Treatment Options ◽  
Correct Diagnosis ◽  
New Treatment ◽  
Poor Outcomes ◽  
Careful Management

Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. The following review will focus on the main risk factors for developing HK and also aims to provide a guide for a correct diagnosis and present new approaches to therapy.

O210 Risk factors for congestive heart failure in patients with chronic kidney disease: the CRIC study

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e58
Author(s):  
Jiang He ◽  
Wei Yang ◽  
Amanda Anderson ◽  
Harold Feldman ◽  
John Kusek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Congestive Heart Failure ◽  
Kidney Disease

Chronic Kidney Disease and End-Stage Renal Disease Are Risk Factors for Poor Outcomes of Clostridium difficile Infection: A Meta-analysis

2015 ◽  
Vol 110 ◽  
pp. S919-S920
Author(s):  
Parkpoom Phatharacharukul ◽  
Charat Thongprayoon ◽  
Wisit Cheungpasitporn ◽  
Peter J. Edmonds ◽  
Quanhathai Kaewpoowat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clostridium Difficile ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Meta Analysis ◽  
Poor Outcomes ◽  
Stage Renal Disease ◽  
End Stage

Anaemia in chronic kidney disease- new treatment options

2018 ◽  
Vol 8 (2) ◽  
pp. 210-214
Author(s):  
M. Żórawski ◽  
B. Musiałowska ◽  
M. Rudzińska ◽  
E. Koc-Żórawska ◽  
J.S. Małyszko
Keyword(s):  
Chronic Kidney Disease ◽  
Bone Marrow ◽  
Kidney Disease ◽  
Treatment Options ◽  
Nutritional Deficiencies ◽  
Renal Anaemia ◽  
Disease Pathogenesis ◽  
Multiple Factors ◽  
Erythrocyte Survival ◽  
New Treatment

In recent years anaemia has been recognized as one of the most specific and evident manifestations of chronic renal failure. In the majority of cases, renal anaemia is normocytic and normochromic with normal cellularity of bone marrow. Multiple factors contribute to the molecular origins of the anaemia of chronic kidney disease. Within those factors, the disturbances in the production of erythropoietin have the greatest impact on the disease pathogenesis. However, other components such as shortened erythrocyte survival, blood loss, iron or other nutritional deficiencies, hemolysis, the presence of uremic inhibitors of erythropoiesis among others can also significantly contribute to the occurrence of anaemia.

scholarly journals Stroke risk factors in patients with end-stage kidney disease: current status of the problem

2020 ◽  
Vol 101 (6) ◽  
pp. 825-833
Author(s):  
I T Murkamilov ◽  
K A Aitbaev ◽  
V V Fomin ◽  
Zh A Murkamilova ◽  
F A Yusupov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Hypertension ◽  
Bone Mineral ◽  
End Stage Kidney Disease ◽  
Common Risk Factors ◽  
End Stage

Chronic kidney disease and its complications are one of the leading causes of morbidity, disability and mortality in the world population, due to both the widespread prevalence of arterial hypertension, diabetes mellitus and coronary heart disease, and the increase in life expectancy. In the terminal stage of chronic kidney disease, mortality from cardiovascular events increases significantly. This review examines the most common risk factors for stroke in end-stage kidney disease. The role of arterial hypertension, diabetes mellitus, chronic heart failure is discussed, taking into account common risk factors, hyperactivation of the renin-angiotensin-aldosterone system, the development of oxidative stress, volume overload with an increase in the size of the left atrium and a subsequent increase in the risk of thrombosis and stroke in patients with end-stage kidney disease on programmed hemodialysis. In addition, data are presented in the study of the contribution of bone mineral disorders to the occurrence of cerebral complications in this category of patients. Timely diagnosis of cardiovascular diseases and secondary prevention of stroke, including adequate antihypertensive, hypoglycemic therapy and correction of heart failure with blockers of the renin-angiotensin-aldosterone system, as well as the elimination of bone mineral disorders are currently a very popular approach to improving the quality of life and increased survival in the discussed category of patients. Understanding the pathogenetic mechanism of stroke in patients with end-stage kidney disease on programmed hemodialysis, with the study of risk factors in the development of an acute cerebrovascular accident, will help to develop a strategy for their management.

scholarly journals Anemia and chronic kidney disease are associated with poor outcomes in heart failure patients

2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Jean-Christophe Luthi ◽  
W Dana Flanders ◽  
Michel Burnier ◽  
Bernard Burnand ◽  
William M McClellan
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Heart Failure Patients ◽  
Poor Outcomes

scholarly journals Individual heterogeneity in the probability of hospitalization, skilled nursing facility admission and mortality

2020 ◽  
Author(s):  
Gail J McAvay ◽  
Brent Vander Wyk ◽  
Heather Allore
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Conditions ◽  
Skilled Nursing Facility ◽  
Joint Modeling ◽  
Sociodemographic Factors ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Poor Outcomes

Abstract Background Multimorbidity is common in adults aged 65 and older, and associated with healthcare utilization, mortality, but most methods ignore the interrelationship among concurrent outcome nor provide person-specific probabilities. Methods A longitudinal cohort of 5,300 older Americans from the 2011-2015 rounds of the National Health and Aging Study was linked to Center for Medicare and Medicaid Services claims. Odds ratios for 15 chronic conditions adjusted for sociodemographic factors were estimated using a joint model of hospitalization, SNF admission and mortality. Additionally, we estimated the person-specific probability of an outcome while currently at risk for other outcomes for different chronic disease combinations demonstrating the heterogeneity across persons with identical chronic conditions. Results During the four-year follow-up period, 2,867 (54.1%) individuals were hospitalized, 1,029 (19.4%) were admitted to a SNF and 1,237 (23.3%) died. Chronic kidney disease, dementia, heart failure and chronic obstructive pulmonary disease had significant increased odds for all three outcomes. By incorporating a person-specific random intercept, there was considerable range of person-specific probabilities for individuals with hypertension, diabetes and depression with dementia, (hospitalization: 0.14-0.61; SNF admission: 0.04-0.28) and without dementia (hospitalization: 0.07-0.44; SNF admission: 0.02-0.15). Such heterogeneity was found among individuals with heart failure, ischemic heart disease, chronic kidney disease, hypertension, hyperlipemia and osteoarthritis with and without Medicare. Conclusions This approach of joint modeling of interrelated concurrent healthcare and mortality outcomes not only provides a cohort-level odds and probabilities but addresses the heterogeneity among otherwise similarly characterized persons identifying those with above average probability of poor outcomes.

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