Correlation of Vitamin D3 (Calcitriol) Serum Concentrations with Vitamin B12 and Folic Acid in Women Undergoing in vitro Fertilisation/Intracytoplasmatic Sperm Injection

2018 ◽  
Vol 84 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Nina Rogenhofer ◽  
Daniela Mischitz ◽  
Corinna Mann ◽  
Johanna Gluderer ◽  
Viktoria von Schönfeldt ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin D3 ◽  
In Vitro Fertilisation ◽  
Serum Concentrations ◽  
Intracytoplasmatic Sperm Injection

scholarly journals Congenital Familial Megaloblastic Anemia

Blood ◽  
1971 ◽  
Vol 37 (6) ◽  
pp. 615-623 ◽  
Author(s):  
BEATRICE C. LAMPKIN ◽  
ALLAN PYESMANY ◽  
CAROL B. HYMAN ◽  
DENMAN HAMMOND
Keyword(s):  
Bone Marrow ◽  
Folic Acid ◽  
Dna Synthesis ◽  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Vitamin Deficiency ◽  
Preliminary Step ◽  
Orotic Aciduria

Abstract Two sisters with a previously unreported megaloblastic anemia unassociated with a deficiency of either folic acid or vitamin B12 are described. Deficiencies of these vitamins were ruled out by standard studies. All other previously reported forms of megaloblastic anemia not secondary to a vitamin deficiency, such as orotic aciduria, were also excluded by appropriate studies. Optimal hemoglobin responses were obtained after the administration of large amounts of both vitamin B12 and folic acid. Because of this hemoglobin response, the conversion of deoxyuridine-5-monophosphate to deoxythymidine-5-monophosphate in vitro was examined in bone marrow samples from both patients using a modification of a method described by Killmann.18 This preliminary step in DNA synthesis was found to be normal. The results of this test and the optimal hemoglobin response after administration of both vitamins suggest that both folic acid and vitamin B12 may be necessary at some other preliminary step in DNA synthesis.

Assessment of Serum Vitamin D, Folic acid and Vitamin B12 in Congenital Heart Disease Patients in a Teritary Hospital

2021 ◽  
Vol 12 (1) ◽  
pp. 844-848
Author(s):  
Lally Hanna Luke ◽  
Anandhi D ◽  
Shiva Kumar K ◽  
Valli G ◽  
Revathi K ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin D3 ◽  
Congenital Heart ◽  
Heart Defects ◽  
Disease Patient ◽  
Serum Vitamin ◽  
Serum Vitamin D

Congenital heart disease patient suffers from malnutrition irrespective of the types of cardiac defects. These children are often admitted in hospitals owing to congenital heart defects. Corrective catherization, proper nutritional intake and counselling can improve the malnutrition. To assess the vitamin status in children with congenital heart disease patients admitted in paediatric general ward of tertiary hospital. The study was a prospective observational study, a total of 100 patients were evaluated for their nutritional deficiency such as serum vitamin D3, folic acid and Vitamin B12 by employing ELISA KITS.  The study observed a significant levels of vitamin D3 and folic acid depletion in congenital heart disease patients. There was no severe depletion of vitamin B12 in the current study. The study had made an insight into the malnutrition status of congenital heart disease patients and recommends consumption of micronutrients in congenital heart defect patients.

scholarly journals VITAMIN B12 AND FOLIC ACID IN RELATION TO METHIONINE SYNTHESIS FROM BETAINE IN VIVO AND IN VITRO

1957 ◽  
Vol 226 (1) ◽  
pp. 95-102
Author(s):  
Jakob A. Stekol ◽  
Sidney Weiss ◽  
Ethel I. Anderson ◽  
Peng Tung Hsu ◽  
Alice Watjen
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Methionine Synthesis

Influence of Folic Acid and Vitamin B12 on Formation of Creatine in vitro and in vivo

Nature ◽  
1951 ◽  
Vol 167 (4261) ◽  
pp. 1067-1068 ◽  
Author(s):  
PREMA FATTERPAKER ◽  
URMILA MARFATIA ◽  
A. SREENIVASAN
Keyword(s):  
Folic Acid ◽  
Vitamin B12

scholarly journals Preimplantation genetic testing for a chr14q32 microdeletion in a family with Kagami-Ogata syndrome and Temple syndrome

2021 ◽  
pp. jmedgenet-2020-107433
Author(s):  
Joan Sabria-Back ◽  
Ana Monteagudo-Sánchez ◽  
Marta Sánchez-Delgado ◽  
Anne C Ferguson-Smith ◽  
Olga Gómez ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Multiple Displacement Amplification ◽  
In Vitro Fertilisation ◽  
Risk Haplotype ◽  
Single Family ◽  
Preimplantation Genetic Testing ◽  
Genome Wide ◽  
Intracytoplasmatic Sperm Injection ◽  
Temple Syndrome

IntroductionKagami-Ogata syndrome (KOS14) and Temple syndrome (TS14) are two disorders associated with reciprocal alterations within the chr14q32 imprinted domain. Here, we present a work-up strategy for preimplantation genetic testing (PGT) to avoid the transmission of a causative micro-deletion.MethodsWe analysed DNA from the KOS14 index case and parents using methylation-sensitive ligation-mediated probe amplification and methylation pyrosequencing. The extent of the deletion was mapped using SNP arrays. PGT was performed in trophectoderm samples in order to identify unaffected embryos. Samples were amplified using multiple displacement amplification, followed by genome-wide SNP genotyping to determine the at-risk haplotype and next-generation sequencing to determine aneuploidies.ResultsA fully methylated pattern at the normally paternally methylated IG-DMR and MEG3 DMR in the KOS14 proband, accompanied by an unmethylated profile in the TS14 mother was consistent with maternal and paternal transmission of a deletion, respectively. Further analysis revealed a 108 kb deletion in both cases. The inheritance of the deletion on different parental alleles was consistent with the opposing phenotypes. In vitro fertilisation with intracytoplasmatic sperm injection and PGT were used to screen for deletion status and to transfer an unaffected embryo in this couple. A single euploid-unaffected embryo was identified resulting in a healthy baby born.DiscussionWe identify a microdeletion responsible for multigeneration KOS14 and TS14 within a single family where carriers have a 50% risk of transmitting the deletion to their offspring. We show that PGT can successfully be offered to couples with IDs caused by genetic anomalies.

scholarly journals Folates, folic acid and preconception care – a review

JRSM Open ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 205427042098087
Author(s):  
Simon H House ◽  
John AA Nichols ◽  
Sarah Rae
Keyword(s):  
Folic Acid ◽  
Adverse Effects ◽  
Recurrent Miscarriage ◽  
Controlled Trial ◽  
Folic Acid Supplementation ◽  
In Vitro Fertilisation ◽  
Folic Acid Fortification ◽  
Beneficial Effects ◽  
Fertility Problems

Summary The link between folate deficiency and congenital spina bifida defects was first suggested in the 1960s. Although the prevention of these defects by preconception folic acid supplementation was confirmed in a large multi-centre controlled trial in 1991, its subsequent implementation as health education advice has made very little difference. North America’s policy of folic acid fortification of flour and bread has had a beneficial impact. No European country has implemented fortification due to concern over possible adverse effects on older subjects, but a recent review shows these to be largely hypothetical and far outweighed by beneficial effects. Recent research by Menezo et al. has, however, shown that folic acid is ineffective for some women with severe fertility problems including recurrent miscarriage and failed in vitro fertilisation. There is a genetically determined bottleneck (677TT) in their folate metabolism that can be successfully overridden by going straight to the next step in the metabolic pathway and taking 5-methylytetrahydrofolate, as a preconception supplement. Menezo suggests that all women with fertility problems should be tested for 677TT. If fortification of flour and bread is to be implemented in the UK, there should be monitoring for possible adverse effects including the incidence of colorectal cancers and cognitive decline. In conclusion, whilst there are concerns that fortification could have a detrimental effect on these conditions, there is sound evidence that it would have much greater beneficial effects.

Sign in / Sign up

Export Citation Format

Share Document