scholarly journals Prenatal Exposure to Persistent Organic Pollutants and Anogenital Distance in Children at 18 Months

2018 ◽  
Vol 90 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Miguel García-Villarino ◽  
Isolina Riaño-Galán ◽  
Ana Cristina Rodriguez-Dehli ◽  
Esther Vizcaíno ◽  
Joan O. Grimalt ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Regression Models ◽  
Reproductive Tract ◽  
In Utero Exposure ◽  
Linear Regression Models ◽  
Anogenital Distance ◽  
Genital Development ◽  
Males And Females

Background: Anogenital distance (AGD) is a measure of in utero exposure to hormonally active agents. The aim of the present study was to evaluate the association between prenatal exposure to persistent organic pollutants (POPs) and AGD. Methods: POP levels were measured in pregnant women, and the AGD was recorded in 43 offspring at 18 months. We used linear regression models to analyze the association between maternal POP exposure and offspring AGD. We defined the anogenital index (AGI) as AGD divided by weight at 18 months (AGI = AGD / weight at 18 months [mm/kg]) and included this variable in the regression models. Results: AGI measure was 2.35 (0.61) and 1.38 (0.45) in males and females, respectively. AGI was inversely associated with lipid-adjusted concentrations of PBDE-99 (β = −0.28, 95% confidence interval [CI]: −0.51, −0.04) and PBDE-153 (β = −0.61, 95% CI: −1.11, −0.11) in males. We did not find any statistically significant relationship between any POPs and AGI in females. Conclusions: Environmental exposure to POPs may affect genital development and result in reproductive tract alterations with potentially relevant health consequences in maturity.

scholarly journals Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children

2013 ◽  
Vol 461-462 ◽  
pp. 222-229 ◽  
Author(s):  
Eleni Papadopoulou ◽  
Marina Vafeiadi ◽  
Silvia Agramunt ◽  
Kleopatra Mathianaki ◽  
Polyxeni Karakosta ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Maternal Diet ◽  
Anogenital Distance

scholarly journals Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

2021 ◽  
Vol 151 ◽  
pp. 106469
Author(s):  
Nuria Güil-Oumrait ◽  
Damaskini Valvi ◽  
Raquel Garcia-Esteban ◽  
Monica Guxens ◽  
Jordi Sunyer ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Cardiometabolic Risk

Prenatal exposure to persistent organic pollutants as a risk factor of offspring metabolic syndrome development during childhood

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marlene Cervantes González
Keyword(s):  
Metabolic Syndrome ◽  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Animal Studies ◽  
Polychlorinated Biphenyl ◽  
Environmental Pollutants ◽  
Epidemiological Studies ◽  
Experimental Findings

Abstract Persistent Organic Pollutants (POPs) are exogenous, artificially made chemicals that can disrupt the biological system of individuals and animals. POPs encompass a variety of chemicals including, dioxins, organochlorines (OCs), polychlorinated biphenyl (PCBs), and perfluoroalkyl substances (PFASs) that contain a long half-life and highly resistant to biodegradation. These environmental pollutants accumulate over time in adipose tissues of living organisms and alter various insulin function-related genes. Childhood Metabolic Syndrome (MetS) consists of multiple cardiovascular risk factors, insulin function being one of them. Over the years, the incidence of the syndrome has increased dramatically. It is imperative to explore the role of persistent organic pollutants in the development of Childhood Metabolic Syndrome. Some epidemiological studies have reported an association between prenatal exposure to POPs and offspring MetS development throughout childhood. These findings have been replicated in animal studies in which these pollutants exercise negative health outcomes such as obesity and increased waist circumference. This review discusses the role of prenatal exposure to POPs among offspring who develop MetS in childhood, the latest research on the MetS concept, epidemiological and experimental findings on MetS, and the POPs modes of action. This literature review identified consistent research results on this topic. Even though the studies in this review had many strengths, one major weakness was the usage of different combinations of MetS criteria to measure the outcomes. These findings elucidate the urgent need to solidify the pediatric MetS definition. An accurate definition will permit scientists to measure the MetS as a health outcome properly and allow clinicians to diagnose pediatric MetS and provide individualized treatment appropriately.

scholarly journals Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Hilde B. Lauritzen ◽  
Tricia L. Larose ◽  
Torbjørn Øien ◽  
Torkjel M. Sandanger ◽  
Jon Ø. Odland ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Prospective Cohort Study ◽  
Persistent Organic Pollutants ◽  
Prospective Cohort ◽  
Child Overweight

scholarly journals Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy

Obesity ◽  
2013 ◽  
Vol 22 (2) ◽  
pp. 488-496 ◽  
Author(s):  
Damaskini Valvi ◽  
Michelle Ann Mendez ◽  
Raquel Garcia-Esteban ◽  
Ferran Ballester ◽  
Jesús Ibarluzea ◽  
...  
Keyword(s):  
Weight Gain ◽  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Rapid Weight Gain

scholarly journals Prenatal exposure to persistent organic pollutants and cognition and motor performance in adolescence

2018 ◽  
Vol 121 ◽  
pp. 13-22 ◽  
Author(s):  
Sietske A. Berghuis ◽  
Koenraad N.J.A. Van Braeckel ◽  
Pieter J.J. Sauer ◽  
Arend F. Bos
Keyword(s):  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Motor Performance

Prenatal Exposure to a Mixture of Persistent Organic Pollutants (POPs) and Child Reading Skills at School Age

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Aimin Chen ◽  
Changchun Xie ◽  
Roman Jandarov ◽  
Ann Vuong ◽  
Kim Dietrich ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Prenatal Exposure ◽  
Persistent Organic Pollutants ◽  
Reading Skills ◽  
School Age
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