scholarly journals Long-Term Survival in Gastroesophageal Junction Adenocarcinoma: Ramucirumab

2018 ◽  
Vol 12 (2) ◽  
pp. 532-539 ◽  
Author(s):  
Maria Angeles Gil-Delgado ◽  
Olivier Lucidarme ◽  
Jean Baptiste Bachet ◽  
Naima Mahi ◽  
David Khayat
Keyword(s):  
Liver Metastases ◽  
Metabolic Response ◽  
Controlled Trial ◽  
Gastroesophageal Junction ◽  
Complete Response ◽  
Term Survival ◽  
Long Term Survival ◽  
Gastroesophageal Junction Adenocarcinoma ◽  
Positron Emission

We report a case of long-term survival with complete response of liver metastases within RAINBOW, a randomized, controlled trial of ramucirumab 8 mg/kg intravenously (days 1, 15) versus placebo, both plus paclitaxel 80 mg/m2 intravenously (days 1, 8, 15), every 4 weeks in patients with previously treated advanced gastroesophageal junction adenocarcinoma. A 64-year-old man with gastroesophageal junction adenocarcinoma and liver metastases received first-line folinic acid, 5-fluorouracil plus oxaliplatin (FOLFOX) following jejunostomy. On liver progression, he enrolled in RAINBOW (April 2012), receiving ramucirumab. In November 2013, positron emission tomography scan was consistent with complete metabolic response, confirmed by a follow-up scan in March 2016.

Improved long-term survival after resection of colorectal liver metastases following staging with FDG positron emission tomography

2014 ◽  
Vol 110 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Reyad A. Abbadi ◽  
Umar Sadat ◽  
Asif Jah ◽  
Raaj K. Praseedom ◽  
Neville V. Jamieson ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Emission Tomography ◽  
Term Survival ◽  
Long Term Survival ◽  
Positron Emission

scholarly journals A Case Report of Long-Term Survival following Hepatic Arterial Infusion ofL-Folinic Acid Modulated 5-Fluorouracil Combined with Intravenous Irinotecan and Cetuximab Followed by Hepatectomy in a Patient with Initially Unresectable Colorectal Liver Metastases

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Kobe Van Bael ◽  
Yanina Jansen ◽  
Teofila Seremet ◽  
Benedikt Engels ◽  
Georges Delvaux ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Folinic Acid ◽  
Metabolic Response ◽  
Multidisciplinary Treatment ◽  
Hepatic Arterial Infusion ◽  
Invasive Adenocarcinoma ◽  
Arterial Infusion ◽  
Term Survival ◽  
Long Term Survival

A 43-year-old women admitted to our hospital for weight loss, anorexia, and abdominal pain was diagnosed with sigmoid neoplasm and multiple bilobar liver metastases. This patient received six cycles of systemic FOLFOX prior to a laparoscopically assisted anterior resection of the rectosigmoid for a poorly differentiated invasive adenocarcinoma T2N2M1, K-RAS negative (wild type). Hepatic arterial infusion (HAI) ofL-folinic acid modulated 5-fluorouracil (LV/5-FU) with intravenous (iv) irinotecan (FOLFIRI) and cetuximab as adjuvant therapy resulted in a complete metabolic response (CR) with CEA normalization. A right hepatectomy extended to segment IV was performed resulting in (FDG-)PET negative remission for 7 months. Solitary intrahepatic recurrence was effectively managed by local radiofrequent ablation following 6c FOLFIRI plus cetuximab iv. Multiple lung lesions and recurrence of pulmonary and local lymph node metastases were successfully treated with fractionated stereotactic radiotherapy (50 Gy) and iv LV/5-FU/oxaliplatin (FOLFOX) plus cetuximab finally switched to panitumumab with CR as a result. At present the patient is in persistent complete remission of her stage IV colorectal cancer, more than 5 years after initial diagnosis of the advanced disease. Multidisciplinary treatment with HAI of chemotherapy (LV/5-FU + CPT-11) plus EGFR-inhibitor can achieve CR of complex unresectable LM and can even result in hepatectomy with possible long-term survival.

scholarly journals Long-Term Survival of Two Patients with Liver Metastases from Advanced Gastric Cancer Treated with Radiofrequency Ablation and Chemotherapy

2021 ◽  
pp. 67-72
Author(s):  
Sung Jin Oh
Keyword(s):  
Gastric Cancer ◽  
Radiofrequency Ablation ◽  
Liver Metastases ◽  
Advanced Gastric Cancer ◽  
Systemic Chemotherapy ◽  
Subtotal Gastrectomy ◽  
Hepatic Metastases ◽  
Term Survival ◽  
Long Term Survival

Liver metastasis from gastric cancer has a very poor prognosis. Herein, we present two cases of liver metastases (synchronous and metachronous) from advanced gastric cancer. In the first case, the patient underwent radical subtotal gastrectomy. Liver metastases occurred 6 months after surgery while the patient was receiving adjuvant chemotherapy, but two hepatic tumors were successfully removed by radiofrequency ablation (RFA). In the second case, liver metastases occurred 15 months after surgery for gastric cancer. The patient also received RFA for one hepatic tumor, and other suspicious metastatic tumors were treated with systemic chemotherapy. Although these case presentations are limited for the efficacy of RFA treatment with systemic chemotherapy for hepatic metastases from gastric cancer, our findings showed long-term survival (overall survival for 108 and 67 months, respectively) of the affected patients, without recurrence. Therefore, we suggest that RFA treatment with systemic chemotherapy could be an effective alternative treatment modality for hepatic metastases from gastric cancer.

scholarly journals P-166 Re-hepatectomy is a predictor of long-term survival in patients that recur after liver resection of colorectal liver metastases

2016 ◽  
Vol 27 ◽  
pp. ii49
Author(s):  
M. Marques ◽  
H.S. de Castro Ribeiro ◽  
W.L. Costa ◽  
A.L. Diniz ◽  
A. Godoy ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Significant Shrinkage of Multifocal Liver Metastases and Long-Term Survival in a Patient With Rectal Cancer, After Trans-Arterial Chemoembolization (TACE)

Medicine ◽  
2015 ◽  
Vol 94 (42) ◽  
pp. e1848 ◽  
Author(s):  
Bogdan Andrei Suciu ◽  
Simona Gurzu ◽  
Lucian Marginean ◽  
Doina Milutin ◽  
Ioana Halmaciu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Liver Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Arterial Chemoembolization
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