Influence of Topical Formulations: Lipid Lamella Organization and Lipid Composition of Stratum Corneum as a Surrogate Marker for Barrier Integrity

2018 ◽  
pp. 166-172 ◽  
Author(s):  
Dorothee Dähnhardt ◽  
Christian Surber ◽  
Stephan Dähnhardt-Pfeiffer
Keyword(s):  
Stratum Corneum ◽  
Lipid Composition ◽  
Surrogate Marker ◽  
Topical Formulations ◽  
Barrier Integrity

scholarly journals Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

2015 ◽  
Vol 51 (4) ◽  
pp. 901-909 ◽  
Author(s):  
Kassandra Azevedo Tadini ◽  
Daiane Garcia Mercurio ◽  
Patrícia Maria Berardo Gonçalves Maia Campos
Keyword(s):  
Mechanical Properties ◽  
Stratum Corneum ◽  
Water Content ◽  
Topical Formulations ◽  
Face Area ◽  
Cutaneous Tissue ◽  
The Face ◽  
Skin Conditions ◽  
Basic Studies ◽  
Stratum Corneum Water Content

abstract Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer(r) CM 825, CutometerSEM 575 and ReviscometerRV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical properties, by decreasing the anisotropy of the face skin. No significant effects were observed in viscoelasticity parameters. In conclusion, the effects of acetyl hexapeptide-3 on the anisotropy of face skin characterize the compound as an effective ingredient for improving conditions of the cutaneous tissue, when used in anti-aging cosmetic formulations.

scholarly journals EFFECT OF THERAPEUTIC ULTRASOUND IN THE RELEASE AND PERMEATION OF CAFFEINE LIPOSOMES IN VERTICAL DIFFUSION SYSTEMS

2019 ◽  
Vol 16 (31) ◽  
pp. 274-280
Author(s):  
Luana MARQUES ◽  
João Alberto TASSINARY ◽  
Bárbara SCHMIDTT ◽  
Paula BIANCHETTI ◽  
Simone STÜLP
Keyword(s):  
Stratum Corneum ◽  
Skin Resistance ◽  
Therapeutic Ultrasound ◽  
Skin Permeability ◽  
Vertical Diffusion ◽  
Topical Formulations ◽  
Diffusion Systems ◽  
Release Analysis ◽  
The Difference ◽  
The Times

The development of new topical formulations provides new release systems of substances that are capable of outline the limitations imposed by the skin permeability of the stratum corneum. A resource used to reduce skin resistance is Therapeutic Ultrasound that by phonophoresis provides adequate concentration of the active to the skin. The study compares the effect of the release and permeation caffeine liposomes 5% combined with ultrasound. In release analysis, caffeine liposomes in times of 5, 10, 15 and 20 minutes were used with the ultrasound. In the permeation analysis, biomembrane snake skin was used in a time of 20 minutes. A difference in the release of the substance was observed, but when compared with the times using the ultrasound, the difference was noticed more markedly so. In terms of permeation, there was a greater increase associated with ultrasound. Thus, the results suggest the importance of phonophoresis increase in permeation of substances on the skin.

Association of dry skin with intercellular lipid composition of stratum corneum after erlotinib administration

2020 ◽  
Vol 86 (2) ◽  
pp. 233-243
Author(s):  
Tomonobu Uchino ◽  
Hiyori Fujino ◽  
Daichi Kamiya ◽  
Tomonori Suzuki ◽  
Yasunori Miyazaki ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Lipid Composition ◽  
Dry Skin ◽  
Intercellular Lipid

Lipid composition of outer stratum corneum and nails in atopic and control subjects

1990 ◽  
Vol 282 (8) ◽  
pp. 549-551 ◽  
Author(s):  
B. Melnik ◽  
J. Hollmann ◽  
U. Hofmann ◽  
M. S. Yuh ◽  
G. Plewig
Keyword(s):  
Stratum Corneum ◽  
Lipid Composition ◽  
Control Subjects ◽  
And Control
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