scholarly journals Comparison of Three Methods Estimating Baseline Creatinine For Acute Kidney Injury in Hospitalized Patients: a Multicentre Survey in Third-Level Urban Hospitals of China

2018 ◽  
Vol 43 (1) ◽  
pp. 125-133
Author(s):  
Xia-bing Lang ◽  
Yi Yang ◽  
Ju-rong Yang ◽  
Jian-xin Wan ◽  
Sheng-qiang Yu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
Urban Hospitals ◽  
Baseline Creatinine

scholarly journals Admission plasma uromodulin and the risk of acute kidney injury in hospitalized patients with cirrhosis: a pilot study

2019 ◽  
Vol 317 (4) ◽  
pp. G447-G452
Author(s):  
Kavish R. Patidar ◽  
Pranav S. Garimella ◽  
Etienne Macedo ◽  
James E. Slaven ◽  
Marwan S. Ghabril ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Predictive Biomarker ◽  
Hospitalized Patients ◽  
Susceptible Population ◽  
Baseline Creatinine ◽  
Low Levels ◽  
Time Of Admission ◽  
Hospital Acquired

Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis. Uromodulin, a protein uniquely produced by the kidney and released both in the urine and circulation, has been shown to regulate AKI and is linked to tubular reserve. Although low levels of urine uromodulin are associated with AKI after cardiac surgery, it is unclear whether circulating uromodulin can stratify the risk of AKI, particularly in a susceptible population such as hospitalized patients with cirrhosis. Thus, we investigated whether plasma uromodulin measured at the time of admission is associated with subsequent hospital-acquired AKI (defined by a rise in serum creatinine >0.3mg/dL within 48 h or ≥ 1.5 times baseline) in patients with cirrhosis. A total of 98 patients [mean age 54 yr, Model for Endstage Liver Disease Sodium (MELD-Na) score 19, and baseline creatinine of 0.95 mg/dL] were included, of which 13% ( n = 13) developed AKI. Median uromodulin levels were significantly lower in patients who developed AKI compared with patients who did not (9.30 vs. 13.35 ng/mL, P = 0.02). After adjusting for age, sex, diabetes, hypertension, albumin, and MELD-Na score as covariates on multivariable logistic regression, uromodulin was independently associated with AKI [odd ratios of 1.19 (95% confidence interval 1.02, 1.37; P = 0.02)]. Lower uromodulin levels on admission are associated with increased odds of subsequent AKI in hospitalized patients with cirrhosis. Further studies are needed to better understand the role of uromodulin in the pathogenesis and as a predictive biomarker of AKI in this population. NEW & NOTEWORTHY In this study, we found that admission plasma uromodulin levels are significantly lower in patients who developed subsequent acute kidney injury (AKI) during their hospital stay compared with patients who did not. Additionally, uromodulin is independently associated with AKI development after adjusting for clinically relevant parameters such as age, sex, diabetes, hypertension, severity of cirrhosis, and kidney function. To our knowledge, this is the first study linking plasma uromodulin with AKI development in patients with cirrhosis.

scholarly journals A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury

2009 ◽  
Vol 24 (9) ◽  
pp. 2739-2744 ◽  
Author(s):  
S. M. Bagshaw ◽  
S. Uchino ◽  
D. Cruz ◽  
R. Bellomo ◽  
H. Morimatsu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Baseline Creatinine

Low sodium to potassium ratio in spot urine sample is associated with progression to acute kidney injury and mortality in hospitalized patients with cirrhosis

2021 ◽  
Author(s):  
Elayne Cristina Morais Rateke ◽  
Camila Matiollo ◽  
Emerita Quintina de Andrade Moura ◽  
Michelle Andrigueti ◽  
Claudia Maccali ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Urine Sample ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
Spot Urine ◽  
Low Sodium ◽  
Spot Urine Sample

scholarly journals Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Isaac E Hall ◽  
Edward P Stern ◽  
Lloyd G Cantley ◽  
Jack A Elias ◽  
Chirag R Parikh
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

scholarly journals Morbid Obesity Is Associated With Mortality And Acute Kidney Injury In Hospitalized Patients With Covid-19

2021 ◽  
Author(s):  
Martín-del-Campo Fabiola ◽  
Ruvalcaba-Contreras Neri ◽  
Velázquez-Vidaurri Alma L ◽  
Cueto-Manzano Alfonso M ◽  
Rojas-Campos Enrique ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

Comparison of Static and Dynamic Baseline Creatinine Surrogates for Defining Acute Kidney Injury

Nephron ◽  
2021 ◽  
pp. 1-11
Author(s):  
David G. Warnock ◽  
Javier A. Neyra ◽  
Etienne Macedo ◽  
Ayme D. Miles ◽  
Ravindra L. Mehta ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Day Length ◽  
University Of Alabama ◽  
Inpatient Mortality ◽  
Baseline Serum ◽  
Net Reclassification Improvement ◽  
Baseline Creatinine ◽  
The University ◽  
Final Cohort

<b><i>Background:</i></b> “Dynamic” baseline serum creatinine (sCr), based on a rolling 48-h window, and a static baseline sCr (previous outpatient sCr) were used to define acute kidney injury (AKI). <b><i>Methods:</i></b> Retrospective cohort study of adult admissions to the University of Alabama (UAB) Health System hospitals for years 2016–2018. Included admissions had &#x3e;1- and &#x3c;180-day length of stay, &#x3e;2 inpatient sCr measurements, and an averaged estimated glomerular filtration rate &#x3e;15 mL/min/1.73 m<sup>2</sup>. The final cohort of 62,380 patients included 100,570 admissions, 3,509 inpatient deaths, and 1,916 admissions with inpatient dialysis. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria and a static or dynamic baseline sCr. Discrimination was evaluated with area under receiver operator curves (AUC), logistic regression, and net reclassification improvement (NRI). <b><i>Results:</i></b> Preadmission outpatient “static” sCr values were available for 43,433 admissions. The lowest sCr value during a rolling 48-h window before each inpatient sCr defined a “dynamic” baseline sCr. Using point-wise comparisons, the dynamic baseline sCr performed better than static baseline sCr for inpatient mortality (AUC [0.819 vs. 0.741; <i>p</i> &#x3c; 0.001] and NRI ≥0.306 [<i>p</i> &#x3c; 0.001]) and inpatient dialysis (AUC [0.903 vs. 0.864; <i>p</i> &#x3c; 0.001] and NRI ≥0.317 [<i>p</i> &#x3c; 0.001]). <b><i>Conclusions:</i></b> The dynamic baseline sCr is available without reference to preadmission sCr values and avoids confounding associated with missing outpatient sCr values. AKI defined with the dynamic baseline sCr significantly improved discrimination of risk for inpatient mortality and dialysis compared to static baseline sCr.

Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites

2013 ◽  
Vol 59 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Salvatore Piano ◽  
Silvia Rosi ◽  
Giulio Maresio ◽  
Silvano Fasolato ◽  
Marta Cavallin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Hospitalized Patients
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