scholarly journals Vitamin D Levels, Body Composition, and Metabolic Factors in Asian Indians: Results from the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Pilot Study

2018 ◽  
Vol 72 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Janet M. Chiang ◽  
Frank Z. Stanczyk ◽  
Alka M. Kanaya
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Body Composition ◽  
Vitamin D Deficiency ◽  
Asian Indians ◽  
Fasting Glucose ◽  
Activity Level ◽  
Metabolic Factors

Background/Aims: Asian Indians have a high prevalence of vitamin D deficiency and metabolic syndrome. Vitamin D deficiency is associated with an increased risk of cardiovascular disease and diabetes. Methods: We performed a cross-sectional study of 150 Asian Indians (50% male) from the San Francisco Bay Area. We assessed the association between 25-OH vitamin D (25-OHD) levels and vitamin D deficiency with body composition (anthropometric and radiographic measures) and metabolic outcomes. Results: In both men and women, the presence of vitamin D deficiency was associated with higher systolic (p = 0.004) and diastolic (p = 0.01) blood pressure, and fasting glucose (p = 0.01). Only in women, vitamin D deficiency status was associated with higher body mass index (BMI), waist-to-hip ratio, visceral fat area, and hepatic fat content after adjusting for age, income, and physical activity level. In women, 25-OHD was also associated with fasting glucose after adjusting for age, income, and physical activity and further adjusting for BMI and waist circumference (β –2.1, 95% CI –0.86 to –0.01, p = 0.04). This association between vitamin D deficiency and metabolic parameters was not significant in men. Conclusions: A lower level of 25-OHD and vitamin D deficiency were associated with higher levels of metabolic factors among Asian Indians. Our findings suggest that 25-OHD metabolism may differ by the distribution of adipose tissue and involve previously unexplored pathways accounting for the variability in the role of vitamin D in cardiovascular disease.

scholarly journals Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

2013 ◽  
Vol 17 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Maryam Rafraf ◽  
Saadat Karimi Hasanabad ◽  
Mohammad Asghari Jafarabadi
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Blood Glucose ◽  
Vitamin D Deficiency ◽  
Energy Intake ◽  
Adolescent Girls ◽  
Fasting Blood Glucose ◽  
Activity Level ◽  
Vitamin D Status

AbstractObjectiveTo investigate vitamin D status and its association with components of the metabolic syndrome (MetS) in adolescent girls attending high school in Boukan, Iran during winter 2012.DesignA cross-sectional study.SettingHigh schools of Boukan city, Iran.SubjectsA sample of 216 girls aged 14–17 years was selected by multistage random sampling from four districts of Boukan. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity and serum 25-hydroxyvitamin D (25(OH)D), fasting blood glucose, TAG and HDL-cholesterol levels of all participants were evaluated. Serum 25(OH)D level <20 ng/ml was defined as vitamin D deficiency.ResultsMean serum 25(OH)D was 7·26 (sd 2·81) ng/ml and 96 % of the participants had vitamin D deficiency. According to age-modified definitions of the National Cholesterol Education Program Adult Treatment Panel III, MetS was diagnosed in 10·6 % of the participants. In multivariable regression analysis after adjustment for BMI, energy intake and physical activity level, serum 25(OH)D was inversely associated with fasting blood glucose (β = −0·143, P = 0·04). No significant relationship was found between serum 25(OH)D and other components of MetS.ConclusionsThe high prevalence of vitamin D deficiency warrants national polices and interventions towards improving this major health problem among adolescent girls. Low 25(OH)D level was significantly associated with increased fasting blood glucose. Prospective studies are needed to determine the effects of vitamin D deficiency on the development of MetS and related metabolic diseases in adolescent girls.

scholarly journals Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
M. R. Lopes ◽  
Paula A. B. Ribeiro ◽  
Priscila Ledur ◽  
Gabriela C. Souza ◽  
Nadine Clausell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Failure ◽  
Vitamin D ◽  
Physical Function ◽  
Vitamin D Deficiency ◽  
Handgrip Strength ◽  
Activity Level ◽  
Exercise Intolerance ◽  
Diabetic Patients ◽  
Patients With Heart Failure

Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C,n=25), vitamin sufficient, diabetes (DS-DM,n=18), vitamin deficient, no diabetes (DD-C,n= 63), and vitamin deficient, diabetes (DD-DM,n=40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups(P=0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m)versusDD-DM (309 ± 116 m);P=0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM(P=0.074)even after being adjusted to physical activity(P=0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.

scholarly journals Is There Association between Vitamin D Concentrations and Body Mass Index Variation in Women Submitted to Y-Roux Surgery?

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Maria Tereza A. dos Santos ◽  
Fabiola Isabel Suano-Souza ◽  
Fernando Luiz Affonso Fonseca ◽  
Marise Lazaretti-Castro ◽  
Roseli Oselka Saccardo Sarni
Keyword(s):  
Bariatric Surgery ◽  
Body Mass Index ◽  
Vitamin D ◽  
Body Composition ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Activity Level ◽  
Controlled Study ◽  
Control Group ◽  
Index Variation

Objective. To evaluate vitamin D deficiency and body composition of women submitted to bariatric surgery and relate their body mass index variation after surgery to 25(OH)D concentrations. Method. A cross-sectional and controlled study was performed including 49 obese adult volunteer women, submitted to Roux-en-Y gastric bypass (RYGB group). Collected Data. Body mass index (BMI), self-declared ethnicity, economic condition, physical activity level, serum concentrations of 25-hydroxycholecalciferol (25(OH)D; radioimmunoassay), parathormone, and body composition by dual-energy X-ray absorptiometry (Hologic DXA-QDR-1000) were collected. Results. 25(OH)D deficiency was found in 27 (55.1%) and 8 (21.1%) in the RYGB and control groups (p=0.002). Secondary hyperparathyroidism was more frequent in the RYGB group compared to the control group (15 (30.6%) versus 1 (2.6%); p=0.001). There was no relation of the studied variables and body composition with 25(OH)D deficiency. 25(OH)D concentrations were correlated (r=−0.531; p<0.001) with BMI reduction, regardless of vitamin D supplementation. Conclusion. Women submitted to bariatric surgery (RYGB) around three years ago had higher BMI and vitamin D deficiency, along with hyperparathyroidism, compared to the control group. There was no association between variables related to body composition and 25(OH)D concentrations. On the other hand, vitamin concentrations correlated negatively to BMI variation after undergoing surgery.

scholarly journals Prevalence of Vitamin D Deficiency and its Associated Risk Factors on Osteoarthritis: A Cross-sectional Survey

2021 ◽  
Author(s):  
Ramadevi Kundur ◽  
Ramaiah Itumalla ◽  
Eitimad Hashim Abdel-Rahman ◽  
Malak Saad Althawainy
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Developmental Process ◽  
Calcium Deficiency ◽  
Metabolic Factors ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Associated Risk Factors

Introduction: Vitamin D Deficiency (VDD) and several other metabolic factors are known to be involved in the aggravation of Osteoarthritis (OA). A better understanding of the role of these metabolic factors and diseases is required to alleviate the OA progression. Aim: To analyse the prevalence of VDD in OA patients and its correlation with co-morbidities such as diabetes, hypertension (HT), Cardiovascular Disease (CVD) and acidity and also to assess the effect of Body Mass Index (BMI) and increasing age on the developmental process of OA. Materials and Methods: A cross-sectional survey was undertaken during September 2018 to March 2019 in King Khaled, King Salman and Hail General Hospitals located in Ha’il province of Kingdom of Saudi Arabia (KSA). The study included 501 participants of OA patients that visited these hospitals. Data pertaining to the variables in this study such as diabetes, HT, cardiovascular problems, vitamin D and calcium deficiency, acidity and anthropometric details was obtained using a structured questionnaire. Data analysis was done using descriptive statistics and Pearson’s correlation with the statistical program SPSS version 21. Results: VDD, calcium deficiency and acidity were the most prevalent factors observed in the patients. Vitamin D and calcium deficiency was observed to be higher in females than males. VDD significantly correlated to diabetes, HT, acidity and age, both in females and males. Cardiovascular disease and BMI correlated with VDD only in males but not in females. BMI showed positive correlation with HT in males (p<0.01) but not females, and also correlated with age (p<0.01) irrespective of gender. Conclusion: The study concluded that VDD is more prevalent in females than males in Ha’il region. It is correlated to variables such as diabetes, HT, acidity, BMI and increasing age, which are identified as risk factors contributing to the progression of OA.

Body composition and concentration of 25-OH vitamin D as metabolic syndrome indicators in patients with non-functioning adrenal incidentalomas

2018 ◽  
Author(s):  
Joanna Kowalska ◽  
Iwona Zielen-Zynek ◽  
Justyna Nowak ◽  
Karolina Kulik-Kupka ◽  
Agnieszka Bedkowska-Szczepanska ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Body Composition ◽  
Adrenal Incidentalomas ◽  
25 Oh Vitamin D

Vitamin D deficiency and risk of metabolic syndrome

2018 ◽  
Author(s):  
Alena Andreeva ◽  
Olga Belyaeva ◽  
Anna Bystrova ◽  
Elena Bajenova ◽  
Tatiana Karonova
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency

Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

2020 ◽  
Vol 20 (8) ◽  
pp. 1282-1294
Author(s):  
Meroua Bouchemal ◽  
Djennat Hakem ◽  
Malha Azzouz ◽  
Chafia Touil-Boukoffa ◽  
Dalila Mezioug
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Active Metabolite ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
No Production ◽  
Immunomodulatory Effects ◽  
Immune Balance ◽  
Vitamin D Levels

Background: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis. Objective: The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunomodulatory effects of its active metabolite. Methods: We evaluated vitamin D status by the electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunomodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF- β and s-CTLA-4 were assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determined ex-vivo, while iNOS expression was assessed by immunofluorescence staining. Results: Severe vitamin D deficiency was registered in Algerian MetS patients. The deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly, α-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up-regulated with α-25 (OH)2D3. Conclusion: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.

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