Is Sclerostin Level Associated with Cardiovascular Diseases in Hemodialysis Patients?

2018 ◽  
Vol 46 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Gokce Kundakci Gelir ◽  
Sule Sengul ◽  
Gokhan Nergizoglu ◽  
Sehsuvar Ertürk ◽  
Neval Duman ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Pulse Wave ◽  
Positive Association ◽  
Multivariate Regression Analysis ◽  
Hemodialysis Patients ◽  
Male Gender ◽  
Regression Analyses ◽  
Sclerostin Level ◽  
Statin Use

Background/Aims: The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). Methods: Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. Results: Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses. Sclerostin associated positively with male gender and statin use but negatively with PTH in multivariate regression analyses. During observation, 30 fatal or nonfatal CVEs were observed. While univariate correlation analysis showed a positive association between PWV and sclerostin, there was no relation between the two in multivariate regression analysis. Conclusion: Further studies are needed to understand the role of sclerostin in predicting PWV changes in HD patients.

Retirement intentions: what is the role of push factors in predicting retirement intentions?

2012 ◽  
Vol 33 (6) ◽  
pp. 988-1008 ◽  
Author(s):  
JODI OAKMAN ◽  
YVONNE WELLS
Keyword(s):  
Job Satisfaction ◽  
Social Cohesion ◽  
Multivariate Regression ◽  
Regression Analyses ◽  
Length Of Service ◽  
Older Employees ◽  
Work Factors ◽  
Retirement Intentions ◽  
Insight Into

ABSTRACTPopulation ageing will significantly impact labour markets in most Organisation for Economic Cooperation and Development countries and as a result individuals will need to remain in paid employment for longer to fund their retirement years. This study examines the retirement intentions of employees of a large public-sector organisation located in Victoria, Australia that was interested in developing policies to assist with retention of their mature-age workforce. Multivariate regression analyses were used to identify the most important predictors of intention to retire. The dependent variable, Intended timing of retirement, was analysed in two forms, as continuous and dichotomised measures. Age and Length of service were strong independent predictors of Intention to retire soon (within five years). Of the work factors that were analysed (Job satisfaction, Job demands, Job control, and Social cohesion), low Job satisfaction and high Social cohesion scores indicated an increased likelihood of retiring soon. The results provide some insight into the development of organisational interventions that might assist with retaining older employees for longer.

Relation of Fatigue with Alexithymia and Depression in Psychiatric Outpatients

2007 ◽  
Vol 105 (2) ◽  
pp. 539-545
Author(s):  
Thomas N. Wise ◽  
Michael J. Sheridan
Keyword(s):  
Primary Care ◽  
Regression Analysis ◽  
Psychosocial Stress ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Psychiatric Outpatients ◽  
The Mean

The complaint of fatigue is common in community, primary care, and psychiatric settings. Fatigue is often associated with depression and psychosocial stress. This report investigated the role of alexithymia and depression in fatigue as reported in a sample of 151 psychiatric outpatients (75 men and 76 women) who completed all scales. The mean age of the sample was 45.5 yr. ( SD = 12.5), and mean education was 16.2 yr. ( SD = 2.4). Fatigue was inversely correlated with education (–.16) and positively correlated with depression (.44), anxiety (.30), and alexithymia (.35). However, in a multivariate regression analysis, only depression and alexithymia remained significant ( p ≤ .01).

scholarly journals Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

2020 ◽  
Author(s):  
Minghui Li ◽  
Aihua Zhan ◽  
Xiao Huang ◽  
Lihua Hu ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave ◽  
Fasting Glucose ◽  
Independent Predictor ◽  
Positive Association ◽  
Regression Analyses ◽  
Registry Study ◽  
Hypertensive Patients ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

scholarly journals Does Prophylactic Administration of Edoxaban Increase D-Dimer Levels after Total Hip Arthroplasty?

2019 ◽  
Vol 8 (5) ◽  
pp. 678 ◽  
Author(s):  
Toshiyuki Kawai ◽  
Yutaka Kuroda ◽  
Koji Goto ◽  
Shuichi Matsuda
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Regression Analyses ◽  
Independent Variables ◽  
Total Hip ◽  
Clinically Important Difference ◽  
Duration Of Surgery ◽  
D Dimer

This study aimed to examine the effect of thromboprophylactic edoxaban on D-dimer levels and anemia after total hip arthroplasty (THA). We retrospectively analyzed data from 349 patients undergoing primary THA. Univariate regression and multivariate regression analyses were performed with D-dimer levels on the 7th, 14th, and 21st days postoperatively as the dependent variable Edoxaban use, age, sex, body mass index (BMI), renal function, drop in hemoglobin (Hb) drop, intraoperative blood loss and duration of surgery as were independent variables. Multivariate regression analysis was also performed with Hb drop as the dependent variable. Edoxaban administration of 15 mg/day and 30 mg/day after THA was correlated with higher D-dimer levels at 21, but not at 7 or 14, days postoperatively. Other significant independent predictors for high D-dimer levels were the duration of surgery (at 7 and 14 days), BMI (at 7 days), sex (at 14 days), and age (at 14 and 21 days). Edoxaban use was significantly, weakly correlated with a larger Hb drop at 7 and 14 days, but this was less than a clinically important difference. D-dimer levels after THA can be elevated by thromboprophylactic edoxaban after three weeks postoperatively.

scholarly journals Thyroid hormones modulate irisin concentrations in patients with recently onset hypothyroidism following total thyroidectomy

2020 ◽  
Author(s):  
R. Bocale ◽  
A. Barini ◽  
A. D‘Amore ◽  
M. Boscherin ◽  
S. Necozione ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Thyroid Hormones ◽  
Total Thyroidectomy ◽  
Replacement Therapy ◽  
Thyroid Function ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Levothyroxine Replacement ◽  
Circulating Levels

Abstract Purpose Irisin is a newly discovered adipo-myokine known for having significant effects on body metabolism. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This study was designed to evaluate the influential role of levothyroxine replacement therapy on circulating levels of irisin in patients with recently onset hypothyroidism following total thyroidectomy. Methods Circulating levels of thyroid hormones, irisin and other metabolic parameters, were assessed in 40 recently thyroidectomized patients (34 females, mean age 50.1 ± 15.2 years) at baseline (5–7 day after surgery) and after 2 months under replacement therapy with levothyroxine. Results At baseline, circulating levels of thyroid hormones were indicative of hypothyroidism (TSH 12.7 ± 5.0 μU/mL, FT3 1.9 ± 0.7 pg/mL, FT4 8.7 ± 3.6 pg/mL). Mean serum irisin concentrations significantly increased after 2 months under replacement therapy with levothyroxine (from 2.2 ± 0.6 to 2.9 ± 0.6 μg/mL, p < 0.0001). Variations of circulating levels of irisin under levothyroxine replacement therapy were directly correlated with those of FT3 (Rho = 0.454, p = 0.0033) and FT4 (Rho = 0.451, p = 0.0035). Multivariate regression analysis revealed that changes in thyroid hormones concentrations explained up to 10% of the variations of serum irisin levels under levothyroxine replacement therapy (FT3 R2 = 0.098, FT4 R2 = 0.103). Conclusion Our study suggests that levothyroxine replacement therapy mildly influences irisin metabolism in patients with recently onset hypothyroidism following total thyroidectomy.

scholarly journals Lymphopenic community acquired pneumonia, an unnoticed phenotype associated to mortality in non immuno-suppressed patients: a retrospective cohort study

2017 ◽  
Author(s):  
Jesus F Bermejo-Martin ◽  
Catia Cilloniz ◽  
Raul Mendez ◽  
Raquel Almansa ◽  
Albert Gabarrus ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Fold Increase ◽  
Multivariate Regression Analysis ◽  
Community Acquired Pneumonia ◽  
Post Discharge ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Immunological Phenotype ◽  
Hospital Clinic

AbstractBackgroundThe role of neutrophil and lymphocyte counts as predictors of prognosis in Community Acquired Pneumonia (CAP) has not been appropriately studied.MethodsThis was a retrospective study to evaluate by multivariate regression analysis, the association between neutrophil and lymphocyte counts with mortality at 30-days post discharge in two large cohorts of hospitalized patients with CAP and no prior immunosupression: a multicentric with 1550 patients recruited at 14 hospitals in Spain and a unicentric with 2840 patients recruited at the Hospital Clinic-Barcelona.FindingsThe unicentric cohort accounted with a higher proportion of critically ill patients: 586 (20·6%) vs 131 (8·5%) and non survivors 245 (8·6%) vs 74 (4·8%). Lymphopenia (< 1000 lymphocytes/mm3) was present in the 52·8% of the patients in both cohorts. A sub-group of lymphopenic patients, those with lymphocyte counts below decil 3 (677 lymphocytes/mm3 in the multicentric cohort and 651 lymphocytes/mm3 in the unicentric one), showed > 2-fold increase in the risk of mortality, independently of the CURB-65 score, critical illness and receiving an appropriated antibiotic treatment: (OR [CI95%], p) (2·18 [1·21- 3·92], 0·009) and (2·33 [1·61-3·33], <0·001) respectively. Neutrophil counts were not associated with mortality risk.InterpretationLymphopenia is present in a half of the patients with CAP needing of hospitalization, in absence of antecendents of immunosupression. Lymphopenic CAP with lymphocyte counts < 664 lymphocytes/mm3 constitutes a particular immunological phenotype of the disease which is associated to an increased risk of mortality.FundingCibeRes, 2009 Support to Research Groups of Catalonia 911, IDIBAPS, SEPAR, SVN

scholarly journals Improved ROSC rates in out-of-hospital cardiac arrest patients after introduction of a text message alert system for trained volunteers

2022 ◽  
Author(s):  
D. M. Oosterveer ◽  
M. de Visser ◽  
C. Heringhaus
Keyword(s):  
Cardiac Arrest ◽  
Multivariate Regression ◽  
Survival Rates ◽  
Text Message ◽  
Positive Association ◽  
Regression Analyses ◽  
Alert System ◽  
Automated External Defibrillators ◽  
Average Survival ◽  
Hospital Cardiac Arrest

Abstract Objective To evaluate whether a text message (TM) alert system for trained volunteers contributed to early cardiopulmonary resuscitation, the use of automated external defibrillators (AEDs), return of spontaneous circulation (ROSC) and survival in out-of-hospital cardiac arrest (OHCA) patients in a region with above-average survival rates. Design Data on all OHCA patients in 2012 (non-TM group) were compared with those of all OHCA patients in 2018 (TM group). The association of the presence of a TM alert system with ROSC and survival was assessed with multivariate regression analyses. Results TM responders reached 42 OHCA patients (15.9%) earlier than the first responders or ambulance. They connected 31 of these 42 OHCA patients (73.8%) to an AED before the ambulance arrived, leading to a higher percentage of AEDs being attached in 2018 compared to the 2012 non-TM group (55% vs 46%, p = 0.03). ROSC was achieved more often in the TM group (61.0% vs 29.4%, p < 0.01). Three-month and 1‑year survival did not differ significantly between the two groups (29.3% vs 24.3%, p = 0.19, and 25.9% vs 23.5%, p = 0.51). Multivariate regression analyses confirmed the positive association of ROSC with the TM alert system (odds ratio 1.49, 95% confidence interval 1.02‑2.19, p = 0.04). Conclusion A TM alert system seems to improve the chain of survival; because TM responders reached patients early, AEDs were attached more often and more OHCA patients achieved ROSC. However, the introduction of a TM alert system was not associated with improved 3‑month or 1‑year survival in a region with above-average survival rates.

scholarly journals The Determinants of Foreign Direct Investment in Pakistan: An Econometric Analysis

2000 ◽  
Vol 5 (1) ◽  
pp. 1-22
Author(s):  
Mohammad Hanif Akhtar
Keyword(s):  
Interest Rates ◽  
Direct Investment ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Political Regime ◽  
The Political ◽  
Market Size ◽  
Regression Analyses ◽  
Market Growth ◽  
Determinants Of Fdi

This study contributes to an understanding of locational determinants of FDI in Pakistan. Although there exists a great deal of literature in this area, there is hardly any evidence of such a study in the case of Pakistan. Economy level analyses are carried out to explore the determinants of FDI through multivariate regression analysis. The results of the multivariate regression analyses reveal that market size, relative interest rates and exchange rates are the major determinants of FDI in Pakistan. The variables such as market growth and political instability were consistently insignificant in the analyses. However, mixed findings were revealed by the variables such as consumer goods imports and the political regime in Pakistan.

scholarly journals A study on mean platelet volume in ischemic cerebrovascular stroke

2018 ◽  
Vol 5 (2) ◽  
pp. 316 ◽  
Author(s):  
Vitan Patel ◽  
Mahendra Parmar ◽  
Kinjal Shah ◽  
Rishikesh Joshi
Keyword(s):  
Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Clinical Severity ◽  
P Value ◽  
Platelet Volume ◽  
The Mean ◽  
Cerebrovascular Stroke

Background: Ischemic Cerebrovascular stroke is one of the largest cause of death and disability. It is usually caused by thrombosis or thromboembolic phenomena. Large platelets are more reactive, produce more prothrombotic factors and aggregate more easily, and can be a major risk factor/indicator for stroke. While the Mean Platelet Volume (MPV) has been studied in detail in cases of IHD, very few studies have been done in stroke, and none in India – prompting this study. We aim to determine whether an association exists between MPV and incidence/severity of stroke.Methods: The study was carried out among fifty patients with an acute ischemic stroke. Clinical severity was assessed using Modified Rankin‘s scale. MPV was measured using an automated analyzer. Fifty controls were recruited and analysed.Results: MPV has got a statistically significant correlation with Ischemic stroke with a p value of < 0.0001. Average MPV in cases was 9.78+1.25 fl vs. controls who average 8.30+1.14 fl. We did not find a statistically significant correlation between clinical severity of stroke and MPV (P = 0.550).Conclusions: This study has shown an elevation of MPV in acute phase of Ischemic stroke. Within this relationship and adjusting for other significant variables in multivariate regression analysis, it can be stated that an increase in MPV is independently associated with stroke. Further research is required into the role of platelet volume in stroke pathology, outcome, and, most importantly, in individuals at risk for stroke. 

scholarly journals Evaluation of pre-operative sino-nasal outcome test- 22 scores as a predictor of outcome in patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis

2019 ◽  
Vol 5 (4) ◽  
pp. 876
Author(s):  
Balasubramanian Krishnaswami ◽  
Prabu Velayutham ◽  
Naveenkumar Pruthivirajan ◽  
Sathiyam Murugesan ◽  
Ramkumar Murugesan
Keyword(s):  
Chronic Rhinosinusitis ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Tertiary Hospital ◽  
Sinus Surgery ◽  
Symptom Improvement ◽  
Regression Analyses ◽  
Runny Nose ◽  
Waking Up ◽  
Snot 22

<p class="abstract"><strong>Background:</strong> Numerous factors are to be considered when offering FESS as a treatment for patients with chronic rhinosinusitis (CRS) who have failed conservative medical treatment. The objective is to evaluate the sino-nasal outcome test (SNOT-22) and other patient demographic characteristics as predictors of postsurgical improvement in patients with CRS.</p><p class="abstract"><strong>Methods:</strong> Consecutive adult subjects presenting to the Otolaryngology clinics in a tertiary hospital, with refractory CRS that required surgery were included. Subjects were excluded if they did not complete both pre and post-operative SNOT-22 Questionnaire. Demographic and baseline measures, including allergic rhinitis, asthma and addiction status, Lund Kennedy endoscopic scores and Lund-Mackay computed tomography (CT) scoring were also obtained for each subject. Regression analyses were performed.  </p><p class="abstract"><strong>Results:</strong> Fifty-one subjects met criteria and were included. These subjects showed a 55.4% overall improvement in postsurgical SNOT-22 evaluations. Multivariate regression analysis revealed that SNOT-22 items related to “runny nose,” “waking up at night”, “need to blow nose”, and “sneezing” were independent predictors of postsurgical SNOT-22 improvement (p&lt;0.05, for all).</p><p class="abstract"><strong>Conclusions:</strong> ENT surgeons can utilize the SNOT-22 tool to predict the possibility of symptom improvement post FESS in patients with CRS.</p>

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