Non-Proximal Renal Tubule-Derived Urinary Exosomal miR-200b as a Biomarker of Renal Fibrosis

Nephron ◽  
2018 ◽  
Vol 139 (3) ◽  
pp. 269-282 ◽  
Author(s):  
Yanting Yu ◽  
Feng Bai ◽  
Nan Qin ◽  
Wenjin Liu ◽  
Qi Sun ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Renal Tubule ◽  
Proximal Renal Tubule

scholarly journals ORAI store‐operated calcium channels are associated with proximal renal tubule dysfunction in diabetic nephropathy (689.13)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Eliana Garcia‐Vaz ◽  
Gui‐Lan Chen ◽  
Sunil Bhandari ◽  
Nikoleta Daskoulidou ◽  
Bo Zeng ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Calcium Channels ◽  
Renal Tubule ◽  
Proximal Renal Tubule

VITAL MICROSCOPY OF PROXIMAL RENAL TUBULE MORPHOLOGY IN RESPONSE TO ONE MINUTE OF ISCHEMIA.

Shock ◽  
1995 ◽  
Vol 3 ◽  
pp. 17
Author(s):  
E. E. Beecherl ◽  
M. W. Petroll ◽  
H. D. Cavanaugh ◽  
G. T. Shires
Keyword(s):  
Renal Tubule ◽  
Proximal Renal Tubule ◽  
Vital Microscopy

Role of intracellular calcium in renal proximal tubule cell volume regulation

1992 ◽  
Vol 263 (5) ◽  
pp. R1086-R1092 ◽  
Author(s):  
D. A. Terreros ◽  
H. Kanli
Keyword(s):  
Carassius Auratus ◽  
Renal Tubule ◽  
Cell Volume Regulation ◽  
K Channel ◽  
Renal Tubules ◽  
Proximal Tubule Cell ◽  
Tubule Cell ◽  
Proximal Renal Tubule ◽  
Tubule Cells

Osmoregulatory Ca2+ signaling in hypotonic solutions was studied with videometric techniques in 158 proximal renal tubules isolated from the teleost Carassius auratus. Absence of extracellular Ca2+, hypoxia (23 mmHg), or NaCN (3 mM) did not alter regulatory volume decreases (RVD). Nevertheless, decrements of intracellular Ca2+ via the A23187 ionophore or after intracellular Ca2+ chelation with indo-1/AM (5 microM) inhibited RVD. In tubules depleted of Ca2+, RVD could only be fully elicited when intracellular Ca2+ pulses were given within 1 min after hypotonic stimulation. While inhibition of Ca2+ release from the endoplasmic reticulum (ER) with 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8, 50 microM) blunted RVD, some of its effects could be reversed with the anion carrier tributyltin (1 microM). Dibutyryl adenosine 3',5'-cyclic monophosphate (cAMP, 0.5 and 1.0 mM) and forskolin (0.25 mM) also impeded RVD; however, their effects could be partially reversed with the K+ ionophore gramicidin (0.5 microM). In conclusion, in Carassius auratus proximal renal tubule cells, RVD is activated by an intracellular Ca2+ signal that likely emanates from the ER and not from the extracellular media or the mitochondrial Ca2+ pool. Ca2+ activation of a cAMP-modulated osmoregulatory K+ channel appears to play an important role.

Mitochondrial Granulation in the Proximal Renal Tubule in Uremia

Nephron ◽  
1979 ◽  
Vol 24 (6) ◽  
pp. 292-296 ◽  
Author(s):  
Joanne O. Whitney ◽  
Joseph R. Goodman ◽  
Carolyn F. Piel
Keyword(s):  
Renal Tubule ◽  
Proximal Renal Tubule

scholarly journals Dietary Phosphorus Transcriptionally Regulates 25-Hydroxyvitamin D-1α-Hydroxylase Gene Expression in the Proximal Renal Tubule

Endocrinology ◽  
2002 ◽  
Vol 143 (2) ◽  
pp. 587-595 ◽  
Author(s):  
Martin Y. H. Zhang ◽  
Xuemei Wang ◽  
Jonathan T. Wang ◽  
Nathalie A. Compagnone ◽  
Synthia H. Mellon ◽  
...  
Keyword(s):  
Renal Tubule ◽  
Hydroxylase Activity ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
Proximal Renal Tubule ◽  
1,25 Dihydroxyvitamin D ◽  
Dietary Phosphorus ◽  
Straight Tubules ◽  
25 Hydroxyvitamin D ◽  
Bowman's Capsule

Abstract Synthesis of the hormone 1,25-dihydroxyvitamin D, the biologically active form of vitamin D, occurs in the kidney and is catalyzed by the mitochondrial cytochrome P450 enzyme, 25-hydroxyvitamin D-1α-hydroxylase (1α-hydroxylase). We sought to characterize the effects of changes in dietary phosphorus on the kinetics of renal mitochondrial 1α-hydroxylase activity and the renal expression of P450c1α and P450c24 mRNA, to localize the nephron segments involved in such regulation, and to determine whether transcriptional mechanisms are involved. In intact mice, restriction of dietary phosphorus induced rapid, sustained, approximately 6- to 8-fold increases in renal mitochondrial 1α-hydroxylase activity and renal P450c1α mRNA abundance. Immunohistochemical analysis of renal sections from mice fed the control diet revealed the expression of 1α-hydroxylase protein in the proximal convoluted and straight tubules, epithelial cells of Bowman’s capsule, thick ascending limb of Henle’s loop, distal tubule, and collecting duct. In mice fed a phosphorusrestricted diet, immunoreactivity was significantly increased in the proximal convoluted and proximal straight tubules and epithelial cells of Bowman’s capsule, but not in the distal nephron. Dietary phosphorus restriction induced a 2-fold increase in P450c1α gene transcription, as shown by nuclear run-on assays. Thus, the increase in renal synthesis of 1,25-dihydroxyvitamin D induced in normal mice by restricting dietary phosphorus can be attributed to an increase in the renal abundance of P450c1α mRNA and protein. The increase in P450c1α gene expression, which occurs exclusively in the proximal renal tubule, is due at least in part to increased transcription of the P450c1α gene.

Electrochemical potentials of chloride in proximal renal tubule of Necturus maculosus

1975 ◽  
Vol 50 (4) ◽  
pp. 695-700 ◽  
Author(s):  
Raja N Khuri ◽  
Samuel K Agulian ◽  
Krikoris Bogharian ◽  
David Aklanjian
Keyword(s):  
Renal Tubule ◽  
Proximal Renal Tubule ◽  
Necturus Maculosus ◽  
Electrochemical Potentials

Cadherin-6, a Cell Adhesion Molecule Specifically Expressed in the Proximal Renal Tubule and Renal Cell Carcinoma

1998 ◽  
Vol 159 (5) ◽  
pp. 1785-1785 ◽  
Author(s):  
R. Paul ◽  
C.M. Ewing ◽  
J.C. Robinson ◽  
F.F. Marshall ◽  
K.R. Johnson ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Adhesion Molecule ◽  
Renal Cell ◽  
Cell Adhesion Molecule ◽  
Renal Tubule ◽  
Proximal Renal Tubule ◽  
A Cell
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