scholarly journals Diagnostic Accuracy of Interleukin-27 between Tuberculous Pleural Effusion and Malignant Pleural Effusion: A Meta-Analysis

Respiration ◽  
2018 ◽  
Vol 95 (6) ◽  
pp. 469-477 ◽  
Author(s):  
Qing Liu ◽  
Yan-Xia Yu ◽  
Xiao-Juan Wang ◽  
Zheng Wang ◽  
Zhen Wang
Keyword(s):  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis ◽  
Tuberculous Pleural Effusion ◽  
Interleukin 27

scholarly journals Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis

Thorax ◽  
2017 ◽  
Vol 73 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Wen Wang ◽  
Qiong Zhou ◽  
Kan Zhai ◽  
Yao Wang ◽  
Jing-Yuan Liu ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Adenosine Deaminase ◽  
Interferon Gamma ◽  
Predictive Value ◽  
Meta Analysis ◽  
Area Under The Curve ◽  
Tuberculous Pleural Effusion ◽  
Interleukin 27 ◽  
Independent Population

BackgroundAccurate differentiating diagnosis is essential for choosing treatment for exudative pleural effusions.ObjectiveTo establish the diagnostic accuracy of interleukin 27 for tuberculous pleural effusion (TPE).MethodsFirst, the concentrations of pleural interleukin 27, interferon-gamma and adenosine deaminase were compared between 51 patients with TPE and 103 with non-TPEs (Beijing cohort), and their diagnostic values were evaluated. These were further verified in another independent population (Wuhan cohort, n=120). In the second part of the study, we performed a meta-analysis.ResultsWith a cut-off value of 591.4 ng/L in the Beijing cohort, the area under the curve, sensitivity, specificity, positive predictive value and negative predictive value of interleukin 27 to diagnose TPE were 0.983 (95% CI 0.947 to 0.997), 96.1% (86.5% to 99.5%), 99.0% (94.7% to 100%), 98.0 (89.4 to 99.9) and 98.1 (93.3 to 99.8), respectively. Excellent diagnostic accuracy of interleukin 27 was also found in the Wuhan cohort and was further confirmed in the meta-analysis. The diagnostic performance of interleukin 27 was comparable to that of interferon-gamma and was more accurate than that of adenosine deaminase. Since the post-test probability of a negative result was always <0.1%, a negative test was considered to exclude TPE in all tuberculosis prevalence settings.ConclusionsInterleukin 27 can be used to diagnose TPE in a high prevalence setting, and a negative result can also be reliably used to rule out TPE in all prevalence settings.

scholarly journals Diagnostic accuracy of endostatin for malignant pleural effusion: a systematic review and meta-analysis

2021 ◽  
Vol 6 ◽  
pp. 5-5
Author(s):  
Si-Yuan Yang ◽  
Ying Zhao ◽  
Xin-Ru Wang ◽  
Jing Wu ◽  
Dan-Ni Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis

scholarly journals Diagnostic accuracy of tumour markers for malignant pleural effusion: a meta-analysis

Thorax ◽  
2008 ◽  
Vol 63 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Q-L Liang ◽  
H-Z Shi ◽  
X-J Qin ◽  
X-D Liang ◽  
J Jiang ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis ◽  
Tumour Markers

scholarly journals Diagnostic accuracy of cancer ratio for malignant pleural effusion: a systematic review and meta-analysis

2019 ◽  
Vol 7 (20) ◽  
pp. 554-554
Author(s):  
Yan-Qiu Han ◽  
Lei Zhang ◽  
Li Yan ◽  
Pei-Heng Ouyang ◽  
Peng Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis

scholarly journals Thoracic ultrasound for malignant pleural effusion: a systematic review and meta-analysis

2020 ◽  
Vol 6 (4) ◽  
pp. 00464-2020
Author(s):  
Akihiro Shiroshita ◽  
Sayumi Nozaki ◽  
Yu Tanaka ◽  
Yan Luo ◽  
Yuki Kataoka
Keyword(s):  
Systematic Review ◽  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis ◽  
Ultrasound Finding ◽  
Cochrane Central Register ◽  
Thoracic Ultrasound ◽  
Central Register ◽  
Low Sensitivity

This systematic review aimed to evaluate the diagnostic accuracy of thoracic ultrasound in malignant pleural effusion.Articles published until December 2019 in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and the International Clinical Trials Registry Platform were screened by two authors independently to extract data and evaluate the risks of bias and applicability using the modified Quality Assessment of Diagnostic Accuracy Studies-2 tool. We described the forest plots of each thoracic ultrasound finding. We estimated the pooled sensitivity and specificity of pleural nodularity using the bivariate random-effects model.We included seven articles and found that each thoracic ultrasound finding had low sensitivity. The pooled specificity of pleural nodularity was 96.9% (95% CI 93.2%–98.6%).In conclusion, thoracic ultrasound is not useful in ruling out malignant pleural effusion. Physicians can proceed rigorously to repeat thoracentesis or other invasive procedures when pleural nodularity is detected.

scholarly journals Unstimulated pleural fluid interferon-gamma for diagnosis of tuberculous pleural effusion: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Ashutosh Nath Aggarwal ◽  
Ritesh Agarwal ◽  
Sahajal Dhooria ◽  
Kuruswamy Thurai Prasad ◽  
Inderpaul Singh Sehgal ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Pleural Fluid ◽  
Interferon Gamma ◽  
Odds Ratio ◽  
Clinical Decision Making ◽  
Meta Analysis ◽  
Clinical Decision ◽  
Diagnostic Odds Ratio ◽  
Tuberculous Pleural Effusion

Objective: Unstimulated interferon-gamma may be a useful pleural fluid biomarker in the diagnosis of tuberculous pleural effusion (TPE). However, the exact threshold of pleural fluid interferon-gamma and its accuracy during routine clinical decision making is not clear. We assessed the performance of pleural fluid interferon-gamma in diagnosing TPE and tried to identify a useful assay threshold. Methods: We queried the PubMed and Embase databases for publications indexed until May 2020 that provided both sensitivity and specificity data on unstimulated pleural fluid interferon-gamma for diagnosis of TPE. A bivariate random effects model was employed to compute summary estimates for diagnostic accuracy parameters, both overall as well as at threshold ranges of <2, 2-5, and >5 IU/mL. Results: We retrieved 2048 citations, of which 67 publications (7153 patients) were assessed in our review. The summary estimates for sensitivity, specificity, and diagnostic odds ratio were 0.93 (95% CI 0.91-0.95), 0.96 (95% CI 0.94-0.97) and 310.72 (95% CI 185.24-521.18) respectively. Increasing interferon-gamma thresholds did not translate into any substantial change in diagnostic performance; however, eight studies using thresholds >5 IU/mL showed poorer diagnostic accuracy estimates as compared to other studies with lower thresholds. None of the prespecified subgroup variables significantly influenced relative diagnostic odds ratio in a multivariate meta-regression model. All publications demonstrated high risk of bias. Conclusion: Unstimulated pleural fluid interferon-gamma level provides excellent accuracy for diagnosing TPE, and has a potential of becoming a first-line test for this purpose.

Diagnostic accuracy of endostatin for malignant pleural effusion: A clinical study and meta-analysis

2015 ◽  
Vol 127 (5) ◽  
pp. 529-534 ◽  
Author(s):  
Panwen Tian ◽  
Yongchun Shen ◽  
Mei Feng ◽  
Jing Zhu ◽  
Haili Song ◽  
...  
Keyword(s):  
Clinical Study ◽  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Effusion ◽  
Meta Analysis
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