scholarly journals Non-Melanoma Skin Cancers at Sites of Previous Frostbite: Case Report and Review

2018 ◽  
Vol 10 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Khalel Imanbayev ◽  
Abay Makishev ◽  
Murat Zhagiparov ◽  
Pauline McLoone
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Capital City ◽  
Cold Temperatures ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Ultraviolet Radiation Exposure ◽  
A Site ◽  
Melanoma Skin

The association between ultraviolet radiation exposure and skin cancer is well established. Limited studies have reported an association between frostbite and the development of non-melanoma skin cancer but evidence for a proven link is insufficient and possible carcinogenic mechanisms have not been fully explored. In this report, 3 cases of non-melanoma skin cancer (1 case of basal cell carcinoma and 2 cases of squamous cell carcinoma of the skin) which developed at a site of previous frostbite caused by exposure to extremely cold temperatures in Astana, the capital city of Kazakhstan, are described.

Variation in Skin Cancer Pattern in the Southwestern Region of Pakistan

2021 ◽  
Vol 15 (12) ◽  
pp. 3402-3404
Author(s):  
Hina , Manzoor ◽  
Najeeb Ahmad ◽  
Zafar H Tanveer ◽  
Khush Naseed Ahmed ◽  
Munir , Ahmed ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Published Data ◽  
Non Melanoma Skin Cancer ◽  
Broad Term ◽  
The Difference ◽  
Field Workers ◽  
Melanoma Skin

Background: Skin cancer is a broad term that refers to a variety of different types of cancer. It is usually recognized as non-melanoma and melanoma skin cancer. In many parts of the world, the prevalence is high, with significant ecological and ethical variation. Objectives: Objective was to determine demographic and histological features of skin cancer in Southwest region of Pakistan. Methodology: This retrospective study was carried out on skin cancer 1169 cases of Centre for Nuclear Medicine and Radiotherapy (CENAR) in Quetta. The data from January 2000 to December 2009 (10Years) was retrieved from record. The aim was to determine the importance of skin cancer in this area, its gender wise distribution and its pathological types. Results: Record of total 9308 cancer patients was retrieved from patients presenting to CENAR Quetta. From 9308 case, 1169(12.5%) patients were of skin cancer which was second most prevalent category of cancer in this area. Prevalence was higher in males with 713(61%) cases as compared to females. Pathologically with 634(54%) cases, the most prevalent category was Squamous cell carcinoma (SCC). Conclusion: Skin cancer is wide-spread type of cancer in patients of south-west region of Pakistan. The findings of this study are not aligned with published data. The difference is because of high altitude of the study area, dry climate and long skin exposure particularly in low socio-economic field workers. Keywords: Skin cancer, gender, Melanoma skin cancer (MSC), Squamous cell carcinoma (SCC), Non-melanoma skin cancer (NMSC), Basal cell carcinoma (BCC),

Surgical Management of Melanoma and Other Skin Cancers

2015 ◽  
Author(s):  
Jennifer A. Wargo ◽  
Kenneth Tenabe
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Stage Iii ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Stage Iv Melanoma ◽  
Melanoma Skin

The prevalence of malignant skin cancers has increased significantly over the past several years. Approximately 1.2 million cases of non-melanoma skin cancer are diagnosed per year. More alarming, up to 80,000 cases of melanoma are diagnosed per year, an incidence that has been steadily increasing, with a lifetime risk of 1 in 50 for the development of melanoma. The disturbing increase in the incidence of both non-melanoma skin cancer and melanoma can largely be attributed to the social attitude toward sun exposure. The clinical assessment and management of skin lesions can be challenging. This review describes the assessment process, including thorough history and examination; the need for possible biopsy; and excision criteria. Specific types of skin cancer are distinguished and include basal cell carcinoma; squamous cell carcinoma; and melanoma; and for each type the incidence; epidemiology; histologic subtypes; diagnosis; and both surgical and non-surgical treatments are provided. Stages I-IV of melanoma are detailed, with prognostic factors described. Surgical treatment for stages I and II include description of the margins of excision and sentinel lymph node biopsy. The surgical treatment of Stage III melanoma further includes therapeutic lymph node dissection and isolated limb perfusion. Adjuvant therapies are also presented and include radiotherapy and chemotherapy. The additional treatment of metastasectomy for Stage IV melanoma is described. For both Stage III and IV melanoma, the study of vaccines to host immune cells is reported. For Stage IV melanoma, the text also describes immunotherapy treatment. Operative procedures specific to superficial and deep groin dissections are outlined. This review contains 9 figures, 3 tables, and 96 references.

Skin cancer

2018 ◽  
Author(s):  
Rubeta Matin ◽  
Jane McGregor ◽  
Catherine Harwood
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Cutaneous Metastasis ◽  
Primary Malignancy ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Cutaneous Lymphomas ◽  
The Uk ◽  
Late Stages ◽  
Melanoma Skin

Skin cancer is very common in the UK, and its incidence is rising rapidly. There are two broad classes of primary skin cancer: non-melanoma and melanoma. Non-melanoma skin cancer is the commonest form (100 000 cases diagnosed annually in the UK), accounting for nine out of ten skin cancers and includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Cutaneous melanoma is less common (10 000 cases diagnosed in the UK annually) but confers a significantly worse prognosis and accounts for 75% of skin cancer related deaths. There are also a number of other, rarer, non-melanoma skin cancers (e.g. appendageal carcinomas, Merkel cell carcinoma, sarcomas, vascular malignancies, and cutaneous lymphomas); however, these account for less than 1% of all skin cancers in the UK and so will not be specifically discussed in this chapter. Cutaneous metastases can occur secondary to any internal cancer or, indeed, to skin cancer (e.g. melanoma). In most cases, cutaneous metastasis occurs after the diagnosis of a primary cancer and usually in late stages of the disease but, in some cases, it may be the first presentation, in which case it should prompt a thorough investigation for the primary malignancy.

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

2020 ◽  
Vol 36 (02) ◽  
pp. 133-140
Author(s):  
Timothy M. Johnson ◽  
Noah R. Smith
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Mohs Surgery ◽  
Skin Cancers ◽  
The Face ◽  
Carcinoma Squamous Cell ◽  
Melanoma Skin

AbstractBasal cell carcinoma, squamous cell carcinoma, and melanoma represent the three most common skin cancers that occur on the face. The most common surgical treatments for facial skin cancers are Mohs surgery and standard local excision. The effective utilization of either of these techniques is based on tumor and patient risk stratification incorporating known risk factors for occult invasion and local recurrence, combined with patient comorbidities, expectations, and desires. Best available evidence highlights multiple and consistent risk factors for each specific skin cancer type, and dictate local control rates reported in the literature. Recognizing gaps in the literature, we compare and review surgical treatment guidelines and data for standard local excision versus Mohs surgery for cutaneous nonmelanoma and melanoma skin cancer. This article serves as a resource for optimal therapeutic decision making for surgical management of skin cancer on the face.

Non-melanoma skin cancer and premalignant conditions

2021 ◽  
pp. 69-78
Author(s):  
Barbara Jemec ◽  
Gregor B.E. Jemec
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Carcinoma Squamous Cell ◽  
Non Surgical Treatment ◽  
Melanoma Skin

This chapter describes the diagnosis, non-surgical treatment, and surgical treatment of non-melanoma skin cancers, such as basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and others.

scholarly journals The incidence and clinical analysis of non-melanoma skin cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Magdalena Ciążyńska ◽  
Grażyna Kamińska-Winciorek ◽  
Dariusz Lange ◽  
Bogumił Lewandowski ◽  
Adam Reich ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Treatment Strategies ◽  
Cancer Registries ◽  
Clinical Analysis ◽  
Tumour Site ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
The Face ◽  
Melanoma Skin

AbstractNon-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. Retrospective analysis of BCCs and SCCs diagnosed and treated across seven sites in Poland from 1999 to 2019. We recorded 13,913 NMSCs occurring in 10,083 patients. BCC represented 85.2% of all cases. SCC patients were older than BCC patients (77.1 ± 11.3 years vs. 70.1 ± 12.3 years, p < 0.01). The nodular subtype was the most common subtype of BCC, followed by the superficial and infiltrative subtypes. The superficial BCC subtype was more common on photoprotected areas (p < 0.01), whereas the nodular BCC subtype occurred on the face (p < 0.01). The high-risk SCC subtypes were more common on face compared to low-risk SCC subtypes (p < 0.01). BCC and SCC are common malignancies developing at various ages and anatomical sites. These data underline the need for better registration policies regarding NMSC in order to improve prevention and treatment strategies for these tumours.

scholarly journals A BRIEF REVIEW OF TREATMENT MODALITIES FOR NON-MELANOMA SKIN CANCER

2021 ◽  
pp. 22-28
Author(s):  
HARSHIT SHAH
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Treatment Modalities ◽  
Skin Area ◽  
Therapeutic Approaches ◽  
Advantages And Disadvantages ◽  
Non Melanoma Skin Cancer ◽  
Surgical Methods ◽  
Melanoma Skin

NMSC (Non-melanoma skin cancer) is the most commonly occurring malignancy in Caucasians. Out of all diagnosed NMSC cases, 95% of the cases are of basal cell carcinoma and squamous cell carcinoma. The therapeutic approaches to cure or ultimately rescue the skin area affected by NMSC include surgical methods, photodynamic therapy, radiation therapy, immunotherapy, and chemotherapy. This article aims to provide a brief overview of the preliminary mechanism of action, clinical studies, advantages, and disadvantages of currently available treatment modalities.

scholarly journals Uma perspectiva mundial do carcinoma de células escamosas de pele

2009 ◽  
Vol 8 (1) ◽  
pp. 91
Author(s):  
Sarah Regina de Paula Sousa ◽  
Júlio Cesar Andriotti Borges ◽  
Pedro Aquino Ferreira Paulo ◽  
Raimundo F. de Araújo-Júnior
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Epidemiology ◽  
Squamous Cells ◽  
Non Melanoma Skin Cancer ◽  
Carcinoma Squamous Cell ◽  
Penile Squamous Cell Carcinoma ◽  
Melanoma Skin

O Carcinoma de Células Escamosas (SCC) é a segunda neoplasia maligna cutânea mais freqüente, causada primordialmente pela exposição crônica e excessiva à radiação ultravioleta. O objetivo deste trabalho é discutir o perfil epidemiológico global do SCC através de uma revisão sistemática. Foi realizada uma busca na base de dados PUBMED com a utilização dos termos: squamous cells skin cancer, epidemiology squamous cells skin cancer, penile squamous cell carcinoma, squamous cell carcinoma of the penis, vulva SCC epidemiology e depletion of ozone layer. Outra busca foi realizada na base de dados SCIENCE DIRECT, com os termos: epidemiology of non-melanoma skin cancer, epidemiology of squamous cells carcinoma, squamous cells carcinoma, skin cancer, e, por fim, o termo UV radiation. No total, 19 artigos foram selecionados, sendo considerados aqueles publicados a partir de 2000. A revisão permitiu verificar que estudos em países de todos os continentes mostram um número crescente de casos, o que configura um grave problema de saúde pública mundial.

scholarly journals Epidemiology of Non-Melanoma Skin Cancer Patients Attending at Hiwa Hospital in Sulaimani City, Iraq

2018 ◽  
pp. 44-48
Author(s):  
Bushra Mohammed Ali ◽  
Hiwa Abas Ahmed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Family History ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
P Value ◽  
Level Of Education ◽  
Non Melanoma Skin Cancer ◽  
History Of ◽  
Sun Light ◽  
Melanoma Skin

Objectives are to identify the frequency of non-melanoma skin cancer cases were registered at Hiwa hospital and to find out the association between cases and controls with their sociodemographic status and risk factors. A case control approach was used, by retrospective chart review of all non-melanoma skin cancer cases presented between 1st of January 2015 till 31st of December 2016 at Sulaimani Hiwa hospital from which 70 cases conducted   and 70 controls from Baxshen hospital. Data entered to Microsoft excel, analysed by SPSS V 21. Chi-square test was employed to assess the association between different variables, P value of 0.05 or less considered as statistical significant This study included 70 cases and 70 controls were age and gender matched,  most of the cases were in between age 56-70 years old, illiterate 39(55.7%),  jobless 26(37.1%), from urban area 45 (64.3%) , married 65 (92.9%). had sufficient income and barely sufficient. About (64%) of cases had squamous cell carcinoma and (36%) had basal cell carcinoma. Most of the cases had family history of skin cancer (11.4%), and 44 (62.9%) of cases had a history of more than 4 hours exposure to sun in a day and 36 (51.4%) of cases were with normal BMI. Most of the cases 32 (45.7%) with type (O) blood group, not smoking cigarette 51 (72.9%) and not drinking alcohol 69 (98.6%). This study showed a statistical significant association between non-melanoma skin cancer with level of education (P value =0.002), family history (P value = 0.02), time of exposure to sun light (P value of < 0.001) and BMI (p value = 0.001).  Skin cancer and cancer percentage were in increase pattern especially non-melanoma skin cancer, most of non-melanoma skin cancer cases were squamous cell carcinoma, with a significant association with level of education, income status, time of exposure to sun light, family history and BMI

scholarly journals Patient-Derived Human Basal and Cutaneous Squamous Cell Carcinoma Tissues Display Apoptosis and Immunomodulation Following Gas Plasma Exposure with a Certified Argon Jet

2021 ◽  
Vol 22 (21) ◽  
pp. 11446
Author(s):  
Fariba Saadati ◽  
Juliane Moritz ◽  
Julia Berner ◽  
Eric Freund ◽  
Lea Miebach ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Plasma Treatment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ex Vivo ◽  
Plasma Exposure ◽  
Gas Plasma ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

Reactive oxygen species (ROS) have been subject of increasing interest in the pathophysiology and therapy of cancers in recent years. In skin cancer, ROS are involved in UV-induced tumorigenesis and its targeted treatment via, e.g., photodynamic therapy. Another recent technology for topical ROS generation is cold physical plasma, a partially ionized gas expelling dozens of reactive species onto its treatment target. Gas plasma technology is accredited for its wound-healing abilities in Europe, and current clinical evidence suggests that it may have beneficial effects against actinic keratosis. Since the concept of hormesis dictates that low ROS levels perform signaling functions, while high ROS levels cause damage, we investigated herein the antitumor activity of gas plasma in non-melanoma skin cancer. In vitro, gas plasma exposure diminished the metabolic activity, preferentially in squamous cell carcinoma cell (SCC) lines compared to non-malignant HaCaT cells. In patient-derived basal cell carcinoma (BCC) and SCC samples treated with gas plasma ex vivo, increased apoptosis was found in both cancer types. Moreover, the immunomodulatory actions of gas plasma treatment were found affecting, e.g., the expression of CD86 and the number of regulatory T-cells. The supernatants of these ex vivo cultured tumors were quantitatively screened for cytokines, chemokines, and growth factors, identifying CCL5 and GM-CSF, molecules associated with skin cancer metastasis, to be markedly decreased. These findings suggest gas plasma treatment to be an interesting future technology for non-melanoma skin cancer topical therapy.

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