scholarly journals Early Markers of Cardiovascular Risk in Autosomal Dominant Polycystic Kidney Disease

2017 ◽  
Vol 42 (6) ◽  
pp. 1290-1302 ◽  
Author(s):  
Silvia Lai ◽  
Daniela Mastroluca ◽  
Silvia Matino ◽  
Valeria Panebianco ◽  
Antonio Vitarelli ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Early Markers ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease

Medicine ◽  
2016 ◽  
Vol 95 (29) ◽  
pp. e4175 ◽  
Author(s):  
Silvia Lai ◽  
Luigi Petramala ◽  
Daniela Mastroluca ◽  
Emanuela Petraglia ◽  
Alessandro Di Gaeta ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease

2018 ◽  
Vol 8 (3) ◽  
pp. 199-207 ◽  
Author(s):  
Antonio Concistrè ◽  
Luigi Petramala ◽  
Gianmarco Scoccia ◽  
Susanna Sciomer ◽  
Valeria Bisogni ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Body Surface ◽  
Autosomal Dominant ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Polycystic Kidney ◽  
Hypertensive Patients ◽  
Autosomal Dominant Polycystic Kidney

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Methods: We performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients. Results: EAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007). Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.

scholarly journals Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
José Luis Gorriz ◽  
David Arroyo ◽  
Luis D’Marco ◽  
Roser Torra ◽  
Patricia Tomás ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Cardiovascular Risk Factors ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Atheromatous Plaque ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
The Impact

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. Methods We evaluated 2445 CKD patients (2010–2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laboratory, vital status, CVE and hospitalizations were collected for 4 years. Results ADPKD patients had a worse renal function and worst achievement of blood pressure, higher parathormone levels but lower proteinuria compared to CKDoe. ADPKD patients presented lower IMT values than other groups, however, an intermediate rate of pathologic ABI and atheromatous plaque was present. More than half of the patients received statins, achieving LDL-c levels < 100 only in 50 and 39.8% of them (ADPKD and CKDoe respectively). The number of CVE during the follow-up period was low. In adjusted Cox regression model, ADPDK had the lowest occurrence of CVE of all three groups (HR:0.422, 95%CI 0.221–0.808, p = 0.009). Conclusion ADPKD patients show intermediate control rates of CVD. A better control of CVD risk seems to be related with a lower load of CVD compared to other groups, which may lead in the long term to a better prognosis. Further investigation is necessary to determine cardiovascular prognosis in ADPKD.

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