scholarly journals Alternating Hypotropia with Pseudoptosis: A New Phenotype of Congenital Cranial Dysinnervation Disorder

2018 ◽  
Vol 9 (1) ◽  
pp. 102-107 ◽  
Author(s):  
Fady Sedarous ◽  
Toby Y.B. Chan ◽  
Inas Makar
Keyword(s):  
Extraocular Muscles ◽  
The Other ◽  
Facial Muscles ◽  
Ocular Movements ◽  
Möbius Syndrome ◽  
Duane Syndrome ◽  
Congenital Cranial Dysinnervation Disorder ◽  
Clinical Conditions ◽  
Congenital Fibrosis ◽  
Anomalous Innervation

Congenital cranial dysinnervation disorders, also known as CCDDs, are characterized by aberrant innervation to extraocular and facial muscles resulting in unusual forms of incomitant strabismus. Anomalous innervation to extraocular muscles can result in a wide variety of phenotypes causing various clinical conditions such as Duane syndrome, congenital fibrosis of the extraocular muscles, and Möbius syndrome. We report a case of bilateral dysinnervation disorder causing atypical ocular movements in both eyes as the patient changes fixation from one eye to the other and from right gaze to left gaze that fits with the wider diagnosis of CCDDs.

scholarly journals »Point-of-Care« D-Dimer Testing

2010 ◽  
Vol 29 (4) ◽  
pp. 282-287 ◽  
Author(s):  
Jovan Antović
Keyword(s):  
Primary Care ◽  
Venous Thromboembolism ◽  
Emergency Departments ◽  
Laboratory Testing ◽  
Point Of Care ◽  
Turnaround Time ◽  
The Other ◽  
Clinical Conditions ◽  
D Dimer ◽  
Laboratory Assay

»Point-of-Care« D-Dimer TestingD-dimer testing is efficient in the exclusion of venous thromboembolism (VTE). D-dimer laboratory assays are predominantly performed in centralised laboratories in intra-hospital settings although most patients with suspected VTE are presented in primary care. On the other hand decreasing turnaround time for laboratory testing may significantly improve efficacy in emergency departments. Therefore an introduction of a rapid, easy to perform point of care (POC) assay for the identification of D-dimer may offer improvement in diagnostics flow of VTE both in primary care and emergency departments while it could also improve our diagnostic possibilities in some other severe clinical conditions (e.g. disseminated intra-vascular coagulation (DIC) and aortic aneurism (AA)) associated with increased D-dimer. Several POC D-dimer assays have been evaluated and majority of them have met the criteria for rapid and safe exclusion of VTE. In our hands three assays (Stratus, Pathfast and Cardiac) have the laboratory performance profile comparable with our routine D-dimer laboratory assay (Tinaqaunt).

To assess the importance of Nidana Parivarjan in the treatment of Urdhvag Amlapitta with Guduchi Satva

2020 ◽  
Vol 5 (04) ◽  
pp. 16-20
Author(s):  
Parag Vishwas Kulkarni ◽  
Mangesh Jagannath Thamake
Keyword(s):  
Treatment Group ◽  
Symptomatic Treatment ◽  
The Other ◽  
Main Principle ◽  
Complete Eradication ◽  
Clinical Conditions ◽  
Better Than

Amlapitta is one of the leading clinical conditions in today’s speedy lifestyle. Present study focuses on this burning issue and its causes mentioned in Ayurved texts and actual causes observed in day to day life. Importance and benefits of Nidanparivarjan over only symptomatic treatment was assessed during this study. Amlapitta cases were diagnosed according to Ayurvedic texts and classified into two groups. One group was administered with only treatment and the other group was advised Nidanparivarjan along with the treatment. At the end of the study, it was found that the group with Nidanparivarjan was more benefited as compared to only treatment group. This clearly states that Ayurvedic method of finding the particular Hetu of the disease and practice of avoiding those Hetu; i.e. Nidanparivarjan leads to better results and complete eradication and prevention of the disease; thus serving the main principle of Ayurved science - Prevention is better than Cure.

Surgical management of pediatric patients with congenital fibrosis of the extraocular muscles

2019 ◽  
Vol 64 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Yoichi Okita ◽  
Akiko Kimura ◽  
Mana Okamoto ◽  
Osamu Mimura ◽  
Fumi Gomi
Keyword(s):  
Surgical Management ◽  
Pediatric Patients ◽  
Extraocular Muscles ◽  
Congenital Fibrosis

scholarly journals Mechanisms of inspiration that modulate cardiovascular control: the other side of breathing

2019 ◽  
Vol 127 (5) ◽  
pp. 1187-1196 ◽  
Author(s):  
Victor A. Convertino
Keyword(s):  
Chronic Obstructive Lung Disease ◽  
Intrathoracic Pressure ◽  
The Other ◽  
Chronic Obstructive ◽  
Human Experiments ◽  
Mueller Maneuver ◽  
Clinical Benefits ◽  
Life Threatening ◽  
Cardiac Filling ◽  
Clinical Conditions

The objective of this minireview is to describe the physiology and potential clinical benefits derived from inspiration. Recent animal and clinical studies demonstrate that one of the body’s natural mechanisms associated with inspiration is to harness the respiratory pump to enhance circulation to vital organs. There is evidence that large reductions in intrathoracic pressure (>20 cmH2O) caused by some inspiration maneuvers (e.g., Mueller maneuver) or pathophysiology (e.g., heart failure, chronic obstructive lung disease) can result in adverse hemodynamic effects. However, the respiratory pump can improve cardiovascular functions when a “sweet spot” for generation of negative intrathoracic pressure during inspiration can be maintained at or less than 10 cmH2O below normal inspiration. These beneficial physiological effects include greater cardiac filling and output, lower intracranial pressure, cardiac baroreflex resetting, greater cerebral blood flow oscillatory patterns, increased vascular pressure gradients, and promoting sustained feedback between sympathetic nerve activity and arterial pressure. In addition to promoting gas exchange, data obtained from numerous animal and human experiments have provided new insights into “the other side of breathing”: the modulation of circulation by reduced intrathoracic pressure generated during inspiration. The translation of these physiological relationships form the basis for the development and application of technologies designed to optimize the intrathoracic pump for treatment of clinical conditions associated with hypovolemia including cardiac arrest, orthostatic hypotension, hemorrhagic shock, and traumatic brain injury. Harnessing these fundamental mechanisms that control cardiopulmonary physiology provides opportunities to use inspiration as a potential tool to help treat significant and often life-threatening circulatory disorders.

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