Epigenetic Regulation of the Promotor Region of Vascular Endothelial Growth Factor-A and Nerve Growth Factor in Opioid-Maintained Patients

2017 ◽  
Vol 23 (5) ◽  
pp. 249-259 ◽  
Author(s):  
Adrian Groh ◽  
Kirsten Jahn ◽  
Alexandra Burkert ◽  
Alexandra Neyazi ◽  
Laura Schares ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Epigenetic Regulation ◽  
Vascular Endothelial ◽  
Nerve Growth ◽  
Promotor Region ◽  
Endothelial Growth Factor

scholarly journals Potential Novel Biomarkers for Diabetic Testicular Damage in Streptozotocin-Induced Diabetic Rats: Nerve Growth Factor Beta and Vascular Endothelial Growth Factor

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ali Rıza Sisman ◽  
Muge Kiray ◽  
Ulas Mehmet Camsari ◽  
Merve Evren ◽  
Mehmet Ates ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Vascular Endothelial ◽  
Testicular Damage ◽  
Nerve Growth ◽  
Novel Biomarkers ◽  
Growth Factor Beta ◽  
Endothelial Growth Factor

Background. It is well known that diabetes mellitus may cause testicular damage. Vascular endothelial growth factor (VEGF) and nerve growth factor beta (NGF-β) are important neurotrophic factors for male reproductive system.Objective. We aimed to investigate the correlation between testicular damage and testicular VEGF and NGF-βlevels in diabetic rats.Methods. Diabetes was induced by streptozotocin (STZ, 45 mg/kg/i.p.) in adult rats. Five weeks later testicular tissue was removed; testicular VEGF and NGF-βlevels were measured by ELISA. Testicular damage was detected by using hematoxylin and eosin staining and periodic acid-Schiff staining, and apoptosis was identified by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL). Seminiferous tubular sperm formation was evaluated using Johnsen’s score.Results. In diabetic rats, seminiferous tubule diameter was found to be decreased; basement membrane was found to be thickened in seminiferous tubules and degenerated germ cells. Additionally, TUNEL-positive cells were increased in number of VEGF+ cells and levels of VEGF and NGF-βwere decreased in diabetic testes. Correlation between VEGF and NGF-βlevels was strong.Conclusion. These results suggest that the decrease of VEGF and NGF-βlevels is associated with the increase of the apoptosis and testicular damage in diabetic rats. Testis VEGF and NGF-βlevels could be potential novel biomarkers for diabetes induced testicular damage.

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