Biochemical, Anthropometric and Lifestyle Factors Related with Weight Maintenance after Weight Loss Secondary to a Hypocaloric Mediterranean Diet

2017 ◽  
Vol 71 (3-4) ◽  
pp. 217-223 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Olatz Izaola ◽  
David Primo ◽  
Hilda F. Ovalle ◽  
Juan Jose Lopez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Mediterranean Diet ◽  
Dietary Intervention ◽  
Weight Maintenance ◽  
Initial Response ◽  
Serum Levels ◽  
Lifestyle Factors ◽  
Model Assessment ◽  
Positive Weight

Background/Aims: The aim of our study was to evaluate the influence of lifestyle factors and molecular biomarkers on the maintenance of the weight lost after a hypocaloric Mediterranean diet. Design: After 3 months on a diet, patients (n = 335) remained with no controlled diet during 3 years and they were revaluated. Results: Using linear regression, in the group of responders, we detected that a positive weight loss at 3 months, serum levels of leptin at 3 months, and each 30 min per week of physical activity were associated with weight loss maintenance. In the model with reduced weight (RW) as dependent variable, a positive weight loss at 3 months was associated with 2.4% RW (95% CI 1.31–8.11; p = 0.015), each unit of serum leptin levels at 3 months with –0.44% RW (95% CI –0.59 to –0.020; p = 0.007), each basal unit homeostasis model assessment for insulin resistance (HOMA-IR) level with –2.32% (95% CI –13.01 to –0.17; p = 0.040), and each 30 min per week of physical activity with 1.58% RW (95% CI 1.08–2.94; p = 0.020). Conclusion: Obese subjects who are on maintenance weight loss after a dietary intervention appear to have a better initial response during the 3 months intervention, more physical activity at 3 years, and lower basal HOMA-IR and leptin after weight loss than those who regain weight.

scholarly journals Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261

2020 ◽  
Vol 13 (6) ◽  
pp. 164-171
Author(s):  
Daniel A. de Luis ◽  
David Primo ◽  
Olatz Izaola ◽  
Emilia Gómez ◽  
Rosario Bachiller
Keyword(s):  
Weight Loss ◽  
Dietary Pattern ◽  
Serum Lipid ◽  
Dietary Intervention ◽  
Metabolic Response ◽  
Serum Levels ◽  
Hypocaloric Diet ◽  
Genotype Distribution ◽  
Model Assessment ◽  
Mediterranean Dietary Pattern

<b><i>Background:</i></b> The role of adiponectin (<i>ADIPOQ</i>) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies. <b><i>Objective:</i></b> Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in <i>ADIPOQ</i>. <b><i>Design:</i></b> A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism. <b><i>Results:</i></b> The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = –15.7 ± 3.9 vs. –4.9 ± 2.9 mg/dL; <i>p</i> = 0.02), LDL cholesterol (Δ = –15.3 ± 3.8 vs. –1.7 ± 1.9 mg/dL; <i>p</i> = 0.01), triglyceride levels (Δ = –23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; <i>p</i> = 0.01), and CRP (Δ = –1.1 ± 0.1 vs. –0.4 ± 0.2 mg/dL; <i>p</i> = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. –0.4 ± 0.3 ng/dL; <i>p</i> = 0.02) increased. Notably, G-allele carriers did not show this improvement. <b><i>Conclusion:</i></b> Non-G-allele carriers of the <i>ADIPOQ</i> variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.

Weight loss "maintainers" vs. "regainers": Posttreatment physical activity facilitates weight maintenance in obese women

2013 ◽  
Author(s):  
Renee T. Degener ◽  
Melissa H. Laitner ◽  
Danielle M. Lespinasse ◽  
Kristen E. Medina ◽  
Stacey N. Maurer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Weight Maintenance ◽  
Obese Women

scholarly journals Session 3 (Joint with the British Dietetic Association): Management of obesity Weight-loss interventions in the treatment of obesity

2009 ◽  
Vol 69 (1) ◽  
pp. 34-38 ◽  
Author(s):  
C. R. Hankey
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Weight Maintenance ◽  
Dietary Advice ◽  
Excess Body Weight ◽  
Lifestyle Interventions ◽  
Post Intervention ◽  
Weight Losses

Treatments to induce weight loss for the obese patient centre on the achievement of negative energy balance. This objective can theoretically be attained by interventions designed to achieve a reduction in energy intake and/or an increase in energy expenditure. Such ‘lifestyle interventions’ usually comprise one or more of the following strategies: dietary modification; behaviour change; increases in physical activity. These interventions are advocated as first treatment steps in algorithms recommended by current clinical obesity guidelines. Medication and surgical treatments are potentially available to those unable to implement ‘lifestyle interventions’ effectively by achieving losses of between 5 kg and 10 kg. It is accepted that the minimum of 5% weight loss is required to achieve clinically-meaningful benefits. Dietary treatments differ widely. Successful weight loss is most often associated with quantification of energy intake rather than macronutrient composition. Most dietary intervention studies secure a weight loss of between 5 kg and 10 kg after intervention for 6 months, with gradual weight regain at 1 year where weight changes are 3–4 kg below the starting weight. Some dietary interventions when evaluated at 2 and 4 years post intervention report the effects of weight maintenance rather than weight loss. Specific anti-obesity medications are effective adjuncts to weight loss, in most cases doubling the weight loss of those given dietary advice only. Greater physical activity alone increases energy expenditure by insufficient amounts to facilitate clinically-important weight losses, but is useful for weight maintenance. Weight losses of between half and three-quarters of excess body weight are seen at 10 years post intervention with bariatric surgery, making this arguably the most effective weight-loss treatment.

scholarly journals Physical Activity, Weight Loss, and Weight Maintenance in the DiOGenes Multicenter Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Marleen A. van Baak ◽  
Gabby Hul ◽  
Arne Astrup ◽  
Wim H. Saris
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Weight Maintenance ◽  
Secondary Analysis ◽  
Maintenance Phase ◽  
Weight Loss Maintenance ◽  
Multicenter Trial ◽  
Matsuda Index ◽  
Training Programmes ◽  
Positive Effect

In this secondary analysis of the DiOGenes study, we investigated whether physical activity (PA) contributes to diet-induced weight loss and helps to reduce subsequent regain. We also studied the associations of PA with changes in cardiometabolic variables. Adults with overweight were included and followed an 8-week low-calorie diet (LCD). When successful (&gt;8% weight loss), participants were randomized to different ad libitum diet groups and were advised to maintain their weight loss over the 6-month intervention period. Body weight (BW), body composition, cardiometabolic variables and subjectively-assessed PA were measured at baseline, at the end of weight loss and at the end of the intervention. BW was reduced by the LCD (from 99.8 ± 16.7 to 88.4 ± 14.9 kg; P &lt; 0.001). This reduction was maintained during the weight maintenance period (89.2 ± 16.0 kg). Total PA (sum score of the three subscales of the Baecke questionnaire) increased during the weight loss period (from 8.16 ± 0.83 to 8.39 ± 0.78; P &lt; 0.001) and this increase was subsequently maintained (8.42 ± 0.90). We found no evidence that baseline PA predicted weight loss. However, a higher level of baseline PA predicted a larger weight-loss-induced improvement in total cholesterol, triglycerides, glucose and CRP, and in post-prandial insulin sensitivity (Matsuda index). Subsequent weight and fat mass maintenance were predicted by the post-weight loss level of PA and associated with changes in PA during the weight maintenance phase. In conclusion, despite the fact that higher baseline levels of PA did not predict more weight loss during the LCD, nor that an increase in PA during the LCD was associated with more weight loss, higher PA levels were associated with more improvements in several cardiometabolic variables. The positive effect of higher PA on weight loss maintenance seems in contrast to randomized controlled trials that have not been able to confirm a positive effect of exercise training programmes on weight loss maintenance. This analysis supports the notion that higher self-imposed levels of PA may improve the cardiometabolic risk profile during weight loss and help to maintain weight loss afterwards.

scholarly journals Higher adherence to the Mediterranean Diet is associated with weight loss maintenance: the MedWeight study

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Dimitrios Poulimeneas ◽  
Katerina Zoupi ◽  
Eirini Mamalaki ◽  
Eirini Bathrellou ◽  
Costas Anastasiou ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Mediterranean Diet ◽  
Dietary Pattern ◽  
Weight Loss Maintenance ◽  
Activity Level ◽  
Obesity Management ◽  
Maximum Weight ◽  
The Mediterranean ◽  
Current Weight

AbstractIntroductionAdherence to the Mediterranean dietary pattern has been associated with numerous health benefits in non-communicable diseases, including obesity management. However, the associations of the Mediterranean Diet with weight loss maintenance remain to be evaluated.MethodsWe analyzed data from 500 participants (61% women) of the MedWeight study. Eligible volunteers were men and women 18–65 years old, reporting an intentional weight loss of at least 10%, starting from a BMI ≥ 25 kg/m2. Based on their current weight, participants were characterized as maintainers (current weight ≤ 90% of maximum weight), or regainers (current weight > 95% of maximum weight). Socio-demographics, lifestyle measurements and weight history were recorded. Dietary intake was assessed by 2 telephone 24-hour recalls. Adherence to the Mediterranean Diet was assessed with the MedDietScore (range 0–55, greater scores showing higher adherence). Physical activity levels were assessed with the International Physical Activity Questionnaire-short form. Results are expressed as means ± SD, frequencies (%) or Odds Ratio [OR; 95%Confidence Interval].ResultsCompared to regainers (31%), maintainers were younger (31.4 ± 10.0 vs. 36.6 ± 10.8 years, p < 0.001), had lower BMI (25.7 ± 4.3 vs. 31.4 ± 5.1 kg/m2, p < 0.001), and had greater initial body weight loss (25.5 ± 8.6% vs. 18.4 ± 6.9%, p < 0.001). Sex and years of formal education were not significantly different between maintainers and regainers (p > 0.05). Being in the highest MedDietScore quintile (vs. the lowest) was associated with 91% higher odds of being a maintainer [crude OR = 1.91; 1.05–3.45]. This association remained significant after adjusting for sex, age, physical activity level (METŸminutes/week) and energy intake (kcal/day) [adjusted OR = 2.01; 1.05–3.83].DiscussionHigher adherence to the Mediterranean Diet was independently associated with 2-fold increased likelihood of weight loss maintenance. Our results highlight the favorable effects of a prudent dietary pattern in long-term obesity management, as well as novel targets for diet planning during weight loss maintenance.

Effective weight-loss using an e-health delivered physical activity and dietary intervention: A federal credit union pilot study

Work ◽  
2016 ◽  
Vol 54 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Mathew J. Gregoski ◽  
Janis Newton ◽  
Catherine G. Ling ◽  
Kathleen Blaylock ◽  
Sheila A.O. Smith ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Pilot Study ◽  
Dietary Intervention ◽  
Credit Union

scholarly journals The Associations Between Socioeconomic Status and Lifestyle Factors in European Adolescents: A Population-based Study

2017 ◽  
Vol 57 (2) ◽  
pp. 111-124
Author(s):  
Dario Novak ◽  
Štefan Lovro ◽  
Branislav Antala ◽  
Arunas Emeljanovas ◽  
Brigita Mieziene ◽  
...  
Keyword(s):  
Physical Activity ◽  
Socioeconomic Status ◽  
Psychological Distress ◽  
Sedentary Behaviour ◽  
Mediterranean Diet ◽  
Vigorous Physical Activity ◽  
Lifestyle Factors ◽  
Cross Sectional ◽  
Independent Variables ◽  
Self Rated Health

Abstract The main purpose of the present study was to determine the associations between socioeconomic status (SES) and lifestyle factors. In this cross-sectional study, participants were 3,072 adolescents from two European countries of Lithuania and Serbia. The dependent variable was SES, while independent variables were gender, adherence to a Mediterranean diet, body-mass index, self-rated health, psychological distress, moderate-to-vigorous physical activity and sedentary behaviour. The associations between dependent and independent variables were analysed by using logistic regression analysis. In univariate model, middle/high SES was associated with higher adherence to a Mediterranean diet (ptrend = 0.003), good self-rated health (OR 1.51; 95 % CI 1.12 to 2.05) and meeting recommendations of moderate-to-vigorous physical activity (OR 2.09; 95 % CI 1.45 to 3.00), yet inversely associated with psychological distress (OR 0.81; 95 % CI 0.66 to 0.99) and sedentary behaviour (OR 0.80; 95 % CI 0.68 to 0.94). No associations were found between SES and bodymass index and gender. In multivariate model, the same associations occurred between middle/high SES and lifestyle factors. In conclusion, special strategies and policies, based on more affordable nutrition and participation in moderate-to-vigorous physical activity, should be implemented within the system.

scholarly journals 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males

2018 ◽  
Vol 120 (10) ◽  
pp. 1107-1116 ◽  
Author(s):  
David J. Clayton ◽  
Jack Biddle ◽  
Tyler Maher ◽  
Mark P. Funnell ◽  
Jack A. Sargeant ◽  
...  
Keyword(s):  
Weight Loss ◽  
Insulin Sensitivity ◽  
Glycaemic Control ◽  
Dietary Intervention ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Energy Restriction ◽  
Fibroblast Growth Factor 21 ◽  
Oral Glucose ◽  
Model Assessment

AbstractIntermittent energy restriction (IER) involves short periods of severe energy restriction interspersed with periods of adequate energy intake, and can induce weight loss. Insulin sensitivity is impaired by short-term, complete energy restriction, but the effects of IER are not well known. In randomised order, fourteen lean men (age: 25 (sd 4) years; BMI: 24 (sd 2) kg/m2; body fat: 17 (4) %) consumed 24-h diets providing 100 % (10 441 (sd 812) kJ; energy balance (EB)) or 25 % (2622 (sd 204) kJ; energy restriction (ER)) of estimated energy requirements, followed by an oral glucose tolerance test (OGTT; 75 g of glucose drink) after fasting overnight. Plasma/serum glucose, insulin, NEFA, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and fibroblast growth factor 21 (FGF21) were assessed before and after (0 h) each 24-h dietary intervention, and throughout the 2-h OGTT. Homoeostatic model assessment of insulin resistance (HOMA2-IR) assessed the fasted response and incremental AUC (iAUC) or total AUC (tAUC) were calculated during the OGTT. At 0 h, HOMA2-IR was 23 % lower after ER compared with EB (P<0·05). During the OGTT, serum glucose iAUC (P<0·001), serum insulin iAUC (P<0·05) and plasma NEFA tAUC (P<0·01) were greater during ER, but GLP-1 (P=0·161), GIP (P=0·473) and FGF21 (P=0·497) tAUC were similar between trials. These results demonstrate that severe energy restriction acutely impairs postprandial glycaemic control in lean men, despite reducing HOMA2-IR. Chronic intervention studies are required to elucidate the long-term effects of IER on indices of insulin sensitivity, particularly in the absence of weight loss.

scholarly journals Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2114 ◽  
Author(s):  
Cristina Bouzas ◽  
Maria del Mar Bibiloni ◽  
Alicia Julibert ◽  
Miguel Ruiz-Canela ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Weight ◽  
Mediterranean Diet ◽  
Longitudinal Research ◽  
Adult Population ◽  
Body Weight Loss ◽  
Health Study ◽  
Mediterranean Population ◽  
The Mediterranean

Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1: <10%, n = 1495; Q2: 10–15%, n = 1804; Q3: <15–20%, n = 1470; Q4: ≥20%, n = 1589). Diet was assessed using a validated food frequency questionnaire and a 17-item Mediterranean diet questionnaire. Physical activity was assessed by the validated Minnesota-REGICOR and the validated Spanish version of the Nurses’ Health Study questionnaire. Results. Participants reporting higher percentages of desired weight loss (Q3 and Q4) were younger, had higher real and perceived BMI and were more likely to have abdominal obesity. Desired weight loss correlated inversely to physical activity (Q1: 2106 MET min/week; Q4: 1585 MET min/week. p < 0.001) and adherence to Mediterranean diet (Q1: 8.7; Q4: 8.3. p < 0.001). Conclusions. In older Mediterranean individuals with weight excess, desired weight loss was inversely associated with Mediterranean lifestyle adherence. Deeply rooted aspects of the MedDiet remained similar across groups. Longitudinal research is advised to be able to establish causality.

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