scholarly journals Successful Treatment of Oral Lichen Planus with Direct-Acting Antiviral Agents after Liver Transplantation for Hepatitis C Virus-Associated Hepatocellular Carcinoma

2017 ◽  
Vol 11 (3) ◽  
pp. 701-710 ◽  
Author(s):  
Yumiko Nagao ◽  
Kazunori Nakasone ◽  
Tatsuji Maeshiro ◽  
Nao Nishida ◽  
Kanae Kimura ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunosuppressive Drugs ◽  
Hcv Infection ◽  
Direct Acting ◽  
Oral Lichen

Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Herein, we report a case of OLP accompanied by HCV-related hepatocellular carcinoma (HCC) that disappeared after liver transplantation and achievement of sustained virological response following interferon (IFN)-free treatment with ledipasvir (LDV) and sofosbuvir (SOF). The 50-year-old patient developed erosive OLP during IFN therapy, with hyperthyroidism at 53 years of age and HCC at 55 years. He received immunosuppressive drugs and IFN-free DAA treatment after liver transplantation at 60 years of age, which led to disappearance of the symptoms of OLP. The patient was treated safely and effectively with LDV/SOF, although it is not known whether the disappearance of OLP resulted from the eradication of HCV or the immunosuppressive therapy.

scholarly journals Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP

2018 ◽  
Vol 18 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Alexandru Mester ◽  
Ondine Lucaciu ◽  
Lidia Ciobanu ◽  
Dragos Apostu ◽  
Aranka Ilea ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Clinical Features ◽  
Oral Lichen Planus ◽  
Hcv Infection ◽  
Adequate Treatment ◽  
Pubmed Database ◽  
Direct Acting ◽  
Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. An electronic search of the PubMed database was conducted until January 2018, using the following keywords: OLP, HCV, corticosteroids, retinoids, immunomodulatory agents, surgical interventions, photochemotherapy, laser therapy, interferon, ribavirin, and direct-acting antivirals. We selected the articles focusing on the clinical features and treatment management of OLP in patients with/without HCV infection. Topical corticosteroids are considered the first-line treatment in OLP. Calcineurin inhibitors or retinoids can be beneficial for recalcitrant OLP lesions. Systemic therapy should be used in the case of extensive and refractory lesions that involve extraoral sites. Surgical intervention is recommended for isolated lesions. In patients with HCV, monotherapy with interferon (IFN)-α may either improve, aggravate or trigger OLP lesions, while combined IFN-α and ribavirin therapy does not significantly influence the progression of lesions. Direct-acting antiviral (DAA) therapy appears to be a promising approach in patients with HCV-related OLP, as it can improve symptoms of both liver disease and OLP, with fewer side effects. Nevertheless, for clinical utility of DAAs in OLP patients, further studies with larger sample sizes, adequate treatment duration, and long term follow-up are required.

Antibodies to epithelial components in oral lichen planus (OLP) associated with hepatitis C virus (HCV) infection

1997 ◽  
Vol 26 (1) ◽  
pp. 36-39 ◽  
Author(s):  
G. Lodi ◽  
I. Olsen ◽  
A. Piattelli ◽  
E. D'Amico ◽  
L. Artese ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Hcv Infection ◽  
Oral Lichen

Clinical impact of direct-acting antiviral treatment on patients affected by hepatitis C virus-related oral lichen planus

2020 ◽  
Vol 73 ◽  
pp. S617
Author(s):  
Marco Di Petrillo ◽  
Dario Di Stasio ◽  
Riccardo Nevola ◽  
Luca Rinaldi ◽  
Luigi Elio Adinolfi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Antiviral Treatment ◽  
Clinical Impact ◽  
Direct Acting Antiviral ◽  
Direct Acting ◽  
Oral Lichen

Hepatitis C virus (HCV)-infection and oral lichen planus

1998 ◽  
Vol 29 (6) ◽  
pp. 1034-1035 ◽  
Author(s):  
Mathias Grote ◽  
Peter A. Reichart ◽  
Thomas Berg ◽  
Uwe Hopf
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Hcv Infection ◽  
Oral Lichen

scholarly journals Oral lichen planus and hepatitis C virus infection; a symbiotic relationship or a mere co-incidence?

2018 ◽  
Vol 6 (3) ◽  
pp. 772
Author(s):  
Malik Adeel Anwar ◽  
Sahar Iqrar ◽  
Zain Akram ◽  
Muhammad Arslan Tayyab ◽  
Nadeem Afzal
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Incidental Finding ◽  
Positive Association ◽  
Hcv Infection ◽  
Common Finding ◽  
Immune Mediated ◽  
Oral Lichen

Background: Lichen planus (LP) is a common idiopathic chronic inflammatory immune mediated mucocutanous disease that effects stratified squamous epithelia and appendices. Hepatitis C virus (HCV) infection is quite common across the world. A couple of reports have suggested positive association of HCV infection and oral lichen planus (OLP) and most of the studies are usually confined to Mediterranean and south European countries. Due to high incidence and suspected alliance between these two diseases in Pakistan, the following study was conducted with the view that it may help clinicians to set guidelines for HCV testing of lichen planus patients.Methods: Approximately 11500 patients from general population coming to dental diagnostics department of Fatima Memorial Hospital, Lahore (from March 2015-February 2016) were screened clinically for OLP and by ELISA for HCV infection. Out of these 11500 patients 103 were selected one of them incidental and the other pre-diagnosed or both incidental and both pre-diagnosed. These patients were unaware but had either one or both OLP and HCV infection which was confirmed clinically and by ELISA respectively.Results: Majority of patients presenting for other dental complaints were unaware of these diseases process going on in them and was mostly an incidental finding by the clinician. Either one or both OLP and HCV infection were more conjoint in females comprising 77.7% of the total subjects. OLP alone was most common finding comprising 66.67% of the cases. HCV infection alone was present in 15.53% whereas 16.50% subjects showed presence of both OLP and HCV infection.Conclusions: The current study could not detect statistically significant relationship between OLP and HCV infection in Pakistani population which could be due to genetic variation or may be geographic relationship.

scholarly journals Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

2016 ◽  
Vol 10 (3) ◽  
pp. 617-622 ◽  
Author(s):  
Kenji Misaka ◽  
Takashi  Kishimoto ◽  
Yuji Kawahigashi ◽  
Michio Sata ◽  
Yumiko Nagao
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Therapeutic Effects ◽  
Direct Acting Antivirals ◽  
Extrahepatic Manifestations ◽  
Long Term Follow Up ◽  
Direct Acting ◽  
Oral Lichen

Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.

scholarly journals Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis

2016 ◽  
Vol 61 (3) ◽  
pp. 282-287 ◽  
Author(s):  
NA Alaizari ◽  
SA Al-Maweri ◽  
HM Al-Shamiri ◽  
B Tarakji ◽  
B Shugaa-Addin
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Virus Infections ◽  
Oral Lichen
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