scholarly journals 7q Deletion/12q Duplication Is the Possible Cause of an Alobar Holoprosencephaly Case

2017 ◽  
Vol 9 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Vassilis Paspaliaris ◽  
Nikolaos Vrachnis ◽  
Zoe Iliodromiti ◽  
Nikolaos Antonakopoulos ◽  
Giorgos Papaioannou ◽  
...  
Keyword(s):  
7Q Deletion ◽  
Possible Cause

Porcine circovirus as a possible cause of postweaning wasting in pigs in Switzerland

2004 ◽  
Vol 146 (10) ◽  
pp. 461-469 ◽  
Author(s):  
S. Staebler ◽  
E. Buergi ◽  
B. Litzenberger ◽  
K. McCullough ◽  
I. McNair ◽  
...  
Keyword(s):  
Porcine Circovirus ◽  
Possible Cause

Recombination, Balancing Selection and Phylogenies in MHC and Self-Incompatibility Genes

Genetics ◽  
2001 ◽  
Vol 159 (4) ◽  
pp. 1833-1844 ◽  
Author(s):  
Mikkel H Schierup ◽  
Anders M Mikkelsen ◽  
Jotun Hein
Keyword(s):  
Major Histocompatibility Complex ◽  
Phylogenetic Tree ◽  
Balancing Selection ◽  
Nucleotide Sequences ◽  
Recombination Process ◽  
Self Incompatibility ◽  
Selection Coefficient ◽  
Histocompatibility Complex ◽  
A Site ◽  
Possible Cause

AbstractUsing a coalescent model of multiallelic balancing selection with recombination, the genealogical process as a function of recombinational distance from a site under selection is investigated. We find that the shape of the phylogenetic tree is independent of the distance to the site under selection. Only the timescale changes from the value predicted by Takahata's allelic genealogy at the site under selection, converging with increasing recombination to the timescale of the neutral coalescent. However, if nucleotide sequences are simulated over a recombining region containing a site under balancing selection, a phylogenetic tree constructed while ignoring such recombination is strongly affected. This is true even for small rates of recombination. Published studies of multiallelic balancing selection, i.e., the major histocompatibility complex (MHC) of vertebrates, gametophytic and sporophytic self-incompatibility of plants, and incompatibility of fungi, all observe allelic genealogies with unexpected shapes. We conclude that small absolute levels of recombination are compatible with these observed distortions of the shape of the allelic genealogy, suggesting a possible cause of these observations. Furthermore, we illustrate that the variance in the coalescent with recombination process makes it difficult to locate sites under selection and to estimate the selection coefficient from levels of variability.

scholarly journals Variants in the AMER1/WTX gene as a possible cause of idiopathic osteoporosis

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100830
Author(s):  
Caroline Caetano ◽  
Manon Ricquebourg ◽  
Thomas Funck-Brentano ◽  
Philippe Orcel ◽  
Martine Cohen-Solal ◽  
...  
Keyword(s):  
Idiopathic Osteoporosis ◽  
Possible Cause
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