scholarly journals Reading First Coordinates from the Nephrogenic Zone in Human Fetal Kidney

Nephron ◽  
2017 ◽  
Vol 138 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Will W. Minuth
Keyword(s):  
Reading First ◽  
Fetal Kidney ◽  
Human Fetal Kidney ◽  
Nephrogenic Zone

scholarly journals Quantitative analysis of the nephron during human fetal kidney development

2005 ◽  
Vol 62 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Marija Dakovic-Bjelakovic ◽  
Slobodan Vlajkovic ◽  
Rade Cukuranovic ◽  
Svetlana Antic ◽  
Goran Bjelakovic ◽  
...  
Keyword(s):  
Gestational Age ◽  
Kidney Development ◽  
Kidney Tissue ◽  
Human Kidney ◽  
Volume Density ◽  
Ureteric Bud ◽  
Fetal Kidney ◽  
Intrauterine Development ◽  
Human Fetal Kidney ◽  
Nephrogenic Zone

Background. The development of human kidney is a complex process. The number, shape, size, and distribution of nephrons as functional units in a kidney, provide some important information about the organization of the kidney. The aim of this study was to extend the knowledge of the developing human kidney by studying nephrons in the kidney's cortex during gestation. Methods. Kidney tissue specimens of 32 human fetuses, the gestational age from IV lunar month (LM IV) to LM X, were analyzed. Specimens were divided in ten groups based on gestational age. Stereological methods were used at the light microscopic level to estimate the volume densities of the corpuscular and tubular components of the nephron in the cortex of the developing human kidney. Results. Nephron polymorphism was the main characteristic of the human fetal kidney during development. In younger fetuses, just below the renal capsule, there was a wide nephrogenic zone. It contained the condensed mesenchyme and terminal ends of the ureteric bud. Nephrons, in the different stages of development, were located around the ureteric bud which branched in the cortical nephrogenic zone and induced nephrogenesis. More mature nephrons were located in the deeper part of the cortex, close to the juxta-medullary junction. During gestation, nephrogenesis continually advanced, and the number of nephrons increased. Glomeruli changed their size and shape, while the tubules changed their length and convolution. Renal cortex became wider and contained the more mature glomeruli and the more convoluted tubules. The volume density of the tubular component of the nephron increased continually from 10.53% (LM IVa) to 27.7% (LM X). Renal corpuscles changed their volume density irregularly during gestation, increasing from 13% (LM IVa) to 15.5% (LM IVb). During the increase of gestational age, the volume density of corpuscular component of the nephron decreased to 11.7% (LM VIII), then went on increasing until the end of the intrauterine development (LM X) when corpuscles occupied 16.73% of the cortical volume. The volume density of the developing nephrons (corpuscular and tubular portion) showed the significant positive correlation (r = 0.85; p<0.01) with gestational age. Conclusion. The present study was one of few quantitative studies of the human developing nephron. Knowledge about the normal development of the human kidney should be important for the future medical practice.

scholarly journals Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1329
Author(s):  
Li Juel Mortensen ◽  
Mette Lorenzen ◽  
Anne Jørgensen ◽  
Jakob Albrethsen ◽  
Niels Jørgensen ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Adrenal Glands ◽  
Seminal Fluid ◽  
Body Fluids ◽  
Luteinizing Hormone Receptor ◽  
Gonadal Function ◽  
Fetal Kidney ◽  
Healthy Men ◽  
Human Fetal Kidney

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are agonists for the luteinizing hormone receptor (LHCGR) which regulates male reproductive function. LHCGR may be released into body fluids. We wish to determine whether soluble LHCGR is a marker for gonadal function. Cross-sectional, longitudinal, and intervention studies on 195 healthy boys and men and 396 men with infertility, anorchia, or Klinefelter Syndrome (KS) were used to correlate LHCGR measured in serum, seminal fluid, urine, and hepatic/renal artery and vein with gonadal function. LHCGR was determined in fluids from in vitro and in vivo models of human testicular tissue and cell lines, xenograft mouse models, and human fetal kidney and adrenal glands. Western blot showed LHCGR fragments in serum and gonadal tissue of similar size using three different antibodies. The LHCGR-ELISA had no species cross-reactivity or unspecific reaction in mouse serum even after human xenografting. Instead, sLHCGR was released into the media after the culture of a human fetal kidney and adrenal glands. Serum sLHCGR decreased markedly during puberty in healthy boys (p = 0.0001). In healthy men, serum sLHCGR was inversely associated with the Inhibin B/FSH ratio (β −0.004, p = 0.027). In infertile men, seminal fluid sLHCGR was inversely associated with serum FSH (β 0.006, p = 0.009), sperm concentration (β −3.5, p = 0.003) and total sperm count (β −3.2, p = 0.007). The injection of hCG lowered sLHCGR in serum and urine of healthy men (p < 0.01). In conclusion, sLHCGR is released into body-fluids and linked with pubertal development and gonadal function. Circulating sLHCGR in anorchid men suggests that sLHCGR in serum may originate from and possibly exert actions in non-gonadal tissues. (ClinicalTrials: NTC01411527, NCT01304927, NCT03418896).

scholarly journals Expression of Stem Cell Markers in the Human Fetal Kidney

PLoS ONE ◽  
2009 ◽  
Vol 4 (8) ◽  
pp. e6709 ◽  
Author(s):  
Sally Metsuyanim ◽  
Orit Harari-Steinberg ◽  
Ella Buzhor ◽  
Dorit Omer ◽  
Naomi Pode-Shakked ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Markers ◽  
Fetal Kidney ◽  
Cell Markers ◽  
Human Fetal Kidney

scholarly journals Spatial relationship between expression of cytokeratin-19 and that of connexin-43 in human fetal kidney

2013 ◽  
Vol 46 (1) ◽  
pp. 32 ◽  
Author(s):  
Keisuke Hieda ◽  
Shogo Hayashi ◽  
Ji Hyun Kim ◽  
Gen Murakami ◽  
Baik Hwan Cho ◽  
...  
Keyword(s):  
Connexin 43 ◽  
Spatial Relationship ◽  
Cytokeratin 19 ◽  
Fetal Kidney ◽  
Human Fetal Kidney

Growth and development of the human fetal kidney

1986 ◽  
Vol 53 (2) ◽  
pp. 273-279 ◽  
Author(s):  
G. K. Mehrotra ◽  
G. Datta ◽  
K. L. Mukherjee
Keyword(s):  
Growth And Development ◽  
Fetal Kidney ◽  
Human Fetal Kidney

scholarly journals Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human Fetal Kidney and During Mouse Embryogenesis

1995 ◽  
Vol 1 (4) ◽  
pp. 457-466 ◽  
Author(s):  
Patricia M. Kessler ◽  
Sandip P. Vasavada ◽  
Raymond R. Rackley ◽  
Thomas Stackhouse ◽  
Fuh-Mei Duh ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Fetal Kidney ◽  
Mouse Embryogenesis ◽  
Von Hippel Lindau ◽  
Human Fetal Kidney

scholarly journals Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development

PLoS Biology ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. e3000152 ◽  
Author(s):  
Mazène Hochane ◽  
Patrick R. van den Berg ◽  
Xueying Fan ◽  
Noémie Bérenger-Currias ◽  
Esmée Adegeest ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Kidney Development ◽  
Fetal Kidney ◽  
Gene Expression Dynamics ◽  
Human Fetal Kidney

In Search of Imprints Left by the Impairment of Nephrogenesis

2019 ◽  
Vol 207 (2) ◽  
pp. 69-82 ◽  
Author(s):  
Will W. Minuth
Keyword(s):  
Late Phase ◽  
Human Kidney ◽  
Late Gestation ◽  
Clinical Aspects ◽  
Pathological Findings ◽  
Fetal Kidney ◽  
Outer Cortex ◽  
Low Birth Weight Babies ◽  
Fetal Human Kidney ◽  
Nephrogenic Zone

Clinical aspects dealing with the impairment of nephrogenesis in preterm and low birth weight babies were intensely researched. In this context it was shown that quite different noxae can harm nephron formation, and that the morphological damage in the fetal kidney is rather complex. Some pathological findings show that the impairment leads to changes in developing glomeruli that are restricted to the maturation zone of the outer cortex in the fetal human kidney. Other data show also imprints on the stages of nephron anlage including the niche, the pretubular aggregate, the renal vesicle, and comma- and S-shaped bodies located in the overlying nephrogenic zone of the rodent and human kidneys. During our investigations it was noticed that the stages of nephron anlage in the fetal human kidney during the phase of late gestation have not been described in detail. To contribute, these stages were recorded along with corresponding images. The initial nephron formation in the rodent kidney served as a reference. Finally, the known imprints left by the impairment in both specimens were listed and discussed. In sum, the relatively paucity of data on nephron formation in the fetal human kidney during the late phase of gestation is a call to start with intense research so that concepts for a therapeutic prolongation of nephrogenesis can be designed.

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