scholarly journals Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients

2017 ◽  
Vol 78 (5-6) ◽  
pp. 320-329 ◽  
Author(s):  
Sebastian Schimrigk ◽  
Martin Marziniak ◽  
Christine Neubauer ◽  
Eva Maria Kugler ◽  
Gudrun Werner ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Treatment Option ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Pain Patients

Assessing Cognitive and Psychomotor Performance Under Long-Term Treatment with Transdermal Buprenorphine in Chronic Noncancer Pain Patients

2007 ◽  
Vol 105 (5) ◽  
pp. 1442-1448 ◽  
Author(s):  
Oguzhan Dagtekin ◽  
Hans J. Gerbershagen ◽  
Werner Wagner ◽  
Frank Petzke ◽  
Lukas Radbruch ◽  
...  
Keyword(s):  
Psychomotor Performance ◽  
Term Treatment ◽  
Chronic Noncancer Pain ◽  
Long Term Treatment ◽  
Noncancer Pain ◽  
Pain Patients

671 DRIVING ABILITY UNDER LONG-TERM TREATMENT WITH CONTROLLED RELEASE OXYCODONE IN NON-CANCER PAIN PATIENTS

2006 ◽  
Vol 10 (S1) ◽  
pp. S175b-S175
Author(s):  
O. Dagtekin ◽  
H.J. Gerbershagen ◽  
A. Delis ◽  
J. Gärtner ◽  
F. Petzke ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Pain ◽  
Term Treatment ◽  
Driving Ability ◽  
Long Term Treatment ◽  
Pain Patients

Long-term treatment of neuropathic pain with a 5% lidocaine medicated plaster

2010 ◽  
Vol 27 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Ilca Ricarda Wilhelm ◽  
Alexander Tzabazis ◽  
Rudolf Likar ◽  
Reinhard Sittl ◽  
Norbert Grieinger
Keyword(s):  
Neuropathic Pain ◽  
Term Treatment ◽  
Long Term Treatment

S189 LONG TERM TREATMENT WITH GABAPENTIN IN AN ANIMAL MODEL OF CENTRAL NEUROPATHIC PAIN

2011 ◽  
Vol 5 (S1) ◽  
pp. 222-222
Author(s):  
C. Baastrup ◽  
N. Andrews ◽  
G. Wegener ◽  
T.S. Jensen ◽  
N.B. Finnerup
Keyword(s):  
Animal Model ◽  
Neuropathic Pain ◽  
Term Treatment ◽  
Central Neuropathic Pain ◽  
Long Term Treatment

scholarly journals Lentivirus Mediated siRNA against GluN2B Subunit of NMDA Receptor Reduces Nociception in a Rat Model of Neuropathic Pain

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Feixiang Wu ◽  
Ruirui Pan ◽  
Jiaying Chen ◽  
Megumi Sugita ◽  
Caiyang Chen ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Term Treatment ◽  
Prolonged Treatment ◽  
Small Interference Rna ◽  
Study Results ◽  
Long Term Treatment ◽  
Mrna And Protein Expression ◽  
Promising Treatment

Although neuropathic pain (NP) is still not fully understood by scientists and clinicians alike, studies suggest that N-methyl-D-aspartate (NMDA) receptors play an important role in the induction and maintenance of NP. A promising treatment for NP is through the downregulation of NMDA subunit GluN2B by RNA interference; however, naked siRNA (small interference RNA) is not effective in long-term treatments. In order to concoct a viable prolonged treatment for NP, Lv-siGluN2B (lentivirus carrying siRNA targeting GluN2B subunit) was prepared and the antinociception effects were observed in chronic constriction injury (CCI) rats in the present study. Results showed that Lv-siGluN2B was transduced into spinal cord cells after intrathecal injections and effectively reduced the nociception induced by sciatic nerve ligation while inhibiting the mRNA and protein expression of GluN2B. This antinociception effect lasted approximately 7 weeks. These findings suggest that GluN2B subunit could be a target for NP treatment and Lv-siGluN2B represents a new potential option for long-term treatment of NP.

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