The History of Movement Disorder Brain Surgery

2018 ◽  
pp. 1-12 ◽  
Author(s):  
L. Dade Lunsford ◽  
Ajay Niranjan
Keyword(s):  
Movement Disorder ◽  
Brain Surgery ◽  
History Of

scholarly journals THE HISTORY OF BRAIN SURGERY

BMJ ◽  
1921 ◽  
Vol 2 (3181) ◽  
pp. 1041-1042 ◽  
Author(s):  
C. Ballance
Keyword(s):  
Brain Surgery ◽  
History Of

scholarly journals Westphal Variant of Huntington's Disease

2017 ◽  
Vol 17 (01) ◽  
pp. 028-030
Author(s):  
L. Cabarcas-Castro ◽  
J. Ramón-Gómez ◽  
A. Zarante-Bahamón ◽  
O. Bernal-Pacheco ◽  
E. Espinosa-García ◽  
...  
Keyword(s):  
Family History ◽  
Huntington's Disease ◽  
Movement Disorder ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Cag Repeats ◽  
Molecular Evidence ◽  
Exon 1 ◽  
History Of

AbstractA Westphal variant of Huntington's disease (HD) is an infrequent presentation of this inherited neurodegenerative disorder. Here, we describe a 14-year-old girl who developed symptoms at the age of 7, with molecular evidence of abnormally expanded Cytosine-Adenine-Guanine (CAG) repeats in exon 1 of the Huntingtin gene. We briefly review the classical features of this variant highlighting the importance of suspecting HD in a child with parkinsonism and a family history of movement disorder or dementia.

The Expression of Schizophrenia, Affective Disorder and Vulnerability to Tardive Dyskinesia in an Extensive Pedigree

1988 ◽  
Vol 153 (3) ◽  
pp. 376-381 ◽  
Author(s):  
John L. Waddington ◽  
Hanafy A. Youssef
Keyword(s):  
Family History ◽  
Tardive Dyskinesia ◽  
Movement Disorder ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Late Onset ◽  
Psychiatric Morbidity ◽  
Neuroleptic Treatment ◽  
History Of

The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chroniC., deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.

scholarly journals The added value of parenchymal transcranial Doppler sonography at the Emergency Room: case report of an unusual gait disorder

2019 ◽  
Author(s):  
Massimiliano Godani ◽  
Giuseppe Lanza ◽  
Rita Bella ◽  
Lucia Trevisan ◽  
Raffaele Ferri
Keyword(s):  
Emergency Room ◽  
Movement Disorder ◽  
Neurological Examination ◽  
Movement Disorders ◽  
Transcranial Doppler ◽  
Doppler Sonography ◽  
Transcranial Doppler Sonography ◽  
Gait Disorder ◽  
Wide Range ◽  
History Of

Abstract Background: the growing application of parenchymal transcranial Doppler sonography (pTCS) helps the diagnosis of a wide range of neurological diseases, especially movement disorders. Here, we report a patient with an unusual gait disorder in whom pTCS performed at the Emergency Room rapidly provided diagnostic clues towards a degenerative movement disorder. Case presentation: A 60-year old man presented at the Emergency Room with a rapidly progressive history of walking difficulty, without falls. He had no family history of neurodegenerative or psychiatric diseases. Because of a depressive disorder arisen one year earlier, he was under oral treatment with escitalopram 10 mg and amisulpride 100 mg daily. Neurological examination showed a gait characterized by ataxia, rigidity, and limping; he also had mild oro-facial and hands dyskinesia, some of which were also present during walking. Brain computed tomography was normal. A pTCS performed at the Emergency Room showed hyperechogenicity of the substantia nigra and the caudate nucleus, bilaterally. This pattern is suggestive of Huntington’s disease (HD), as confirmed by the molecular genetic test carried out later. Other laboratory tests, standard electroencephalogram, and 1.5-T brain MRI were normal.Conclusions: to date, this is the first report of HD sonographically detected at the Emergency Room. This supports the view that pTCS can be easily implemented in the diagnostic algorithm and differential diagnosis of movement disorders even in an urgency setting. Notably, conventional MRI did not detect, at this stage, any abnormality; this further highlights the diagnostic utility of pTCS, which also allowed to exclude a drug-induced effect or a different movement disorder. In clinically suspected cases, pTCS can extend the neurological examination by providing diagnostic clues more rapidly and less expensively than neuroimaging.

scholarly journals The added value of parenchymal transcranial Doppler sonography at the Emergency Room: case report of an unusual gait disorder

2019 ◽  
Author(s):  
Massimiliano Godani ◽  
Giuseppe Lanza ◽  
Rita Bella ◽  
Lucia Trevisan ◽  
Raffaele Ferri
Keyword(s):  
Emergency Room ◽  
Movement Disorder ◽  
Neurological Examination ◽  
Movement Disorders ◽  
Transcranial Doppler ◽  
Doppler Sonography ◽  
Transcranial Doppler Sonography ◽  
Gait Disorder ◽  
Wide Range ◽  
History Of

Abstract Background: the growing application of parenchymal transcranial Doppler sonography (pTCS) helps the diagnosis of a wide range of neurological diseases, especially movement disorders. Here, we report a patient with an unusual gait disorder in whom pTCS performed at the Emergency Room rapidly provided diagnostic clues towards a degenerative movement disorder. Case presentation: A 60-year old man presented at the Emergency Room with a rapidly progressive history of walking difficulty, without falls. He had no family history of neurodegenerative or psychiatric diseases. Because of a depressive disorder arisen one year earlier, he was under oral treatment with escitalopram 10 mg and amisulpride 100 mg daily. Neurological examination showed a gait characterized by ataxia, rigidity, and limping; he also had mild oro-facial and hands dyskinesia, some of which were also present during walking. Brain computed tomography was normal. A pTCS performed at the Emergency Room showed hyperechogenicity of the substantia nigra and the caudate nucleus, bilaterally. This pattern is suggestive of Huntington’s disease (HD), as confirmed by the molecular genetic test carried out later. Other laboratory tests, standard electroencephalogram, and 1.5-T brain MRI were normal.Conclusions: to date, this is the first report of HD sonographically detected at the Emergency Room. This supports the view that pTCS can be easily implemented in the diagnostic algorithm and differential diagnosis of movement disorders even in an urgency setting. Notably, conventional MRI did not detect, at this stage, any abnormality; this further highlights the diagnostic utility of pTCS, which also allowed to exclude a drug-induced effect or a different movement disorder. In clinically suspected cases, pTCS can extend the neurological examination by providing diagnostic clues more rapidly and less expensively than neuroimaging.

scholarly journals Midbrain/pons area ratio and clinical features predict the prognosis of Progressive Supranuclear Palsy

2020 ◽  
Author(s):  
shishuang cui ◽  
huawei ling ◽  
juanjuan du ◽  
yiqi lin ◽  
jing pan ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Movement Disorder ◽  
Late Onset ◽  
Age At Onset ◽  
Early Death ◽  
Area Ratio ◽  
Cox Proportional Hazard ◽  
Kaplan Meier ◽  
History Of

Abstract Backgrounds: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, sex, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. Kaplan-Meier method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization. Results: 59 patients fulfilling MDS-PSP criteria were enrolled in our study. 19 patients (32.2%) had died and 31 patients (52.5%) were institutionalizedl by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio. Conclusion: older and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.

scholarly journals Midbrain/pons area ratio and clinical features predict the prognosis of progressive Supranuclear palsy

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shi-Shuang Cui ◽  
Hua-Wei Ling ◽  
Juan-Juan Du ◽  
Yi-Qi Lin ◽  
Jing Pan ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Movement Disorder ◽  
Late Onset ◽  
Age At Onset ◽  
Early Death ◽  
Area Ratio ◽  
Cox Proportional Hazard ◽  
Kaplan Meier ◽  
History Of

Abstract Background Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, sex, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. Kaplan-Meier method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization. Results Fifty-nine patients fulfilling MDS-PSP criteria were enrolled in our study. Nineteen patients (32.2%) had died and 31 patients (52.5%) were institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio. Conclusion Older AAO and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.

scholarly journals Midbrain/pons area ratio and clinical features predict the prognosis of Progressive Supranuclear Palsy

2020 ◽  
Author(s):  
Shishuang Cui ◽  
Huawei Ling ◽  
Juanjuan Du ◽  
Yiqi Lin ◽  
Jing Pan ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Movement Disorder ◽  
Late Onset ◽  
Age At Onset ◽  
Early Death ◽  
Area Ratio ◽  
Cox Proportional Hazard ◽  
Kaplan Meier ◽  
History Of

Abstract Backgrounds: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, sex, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. Kaplan-Meier method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization. Results: 59 patients fulfilling MDS-PSP criteria were enrolled in our study. 19 patients (32.2%) had died and 31 patients (52.5%) were institutionalizedl by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio. Conclusion: older and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.

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