scholarly journals Primary Hepatic Angiosarcoma: A Case Report with 10-Year Patient Medical Data

2017 ◽  
Vol 10 (3) ◽  
pp. 851-856 ◽  
Author(s):  
Masanori Ogawa ◽  
Ryusuke Ae ◽  
Teppei Sasahara
Keyword(s):  
Abdominal Pain ◽  
Fatty Liver ◽  
Case Reports ◽  
Disease Onset ◽  
Health Checkup ◽  
Thorium Dioxide ◽  
Hepatic Angiosarcoma ◽  
First Case ◽  
Primary Hepatic Angiosarcoma ◽  
Case Presentations

In the current study, we report a case of a 46-year-old man who presented with sudden abdominal pain and was diagnosed with rupture of hepatic angiosarcoma (HAS). He underwent surgery, but died 13 days after the onset of the abdominal pain. Chronic exposure to carcinogens, such as thorium dioxide, arsenic, vinyl chloride, and radium, is associated with HAS. However, our patient had not been exposed to such carcinogens. He had submitted himself for annual medical checkups since he was employed. His liver was cirrhotic, and medical history data showed that he had had fatty liver for at least 10 years before HAS onset. Although liver cirrhosis may play a role in the occurrence of HAS, the connection of chronic fatty liver in the tumorigenesis remains unclear. Case reports regarding HAS with fatty liver are few. To the best of our knowledge, this is the first case of HAS occurring in a cirrhotic liver that advanced from persistent fatty stage. Given that HAS is a rare tumor, data collection is important for investigating its pathophysiology. Case presentations considering health conditions before HAS onset are limited; therefore, we present a case of HAS with annual health checkup data before disease onset.

scholarly journals Double Perforated Kissing Ulcers of Duodenum: A Brief Report

2019 ◽  
Vol 103 (1-2) ◽  
pp. 36-39
Author(s):  
Tania Triantafyllou ◽  
Kokoroskos Nikolaos ◽  
Papailiou Joanna ◽  
Linardoutsos Dimitrios ◽  
Zografos Georgios ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Abdominal Pain ◽  
Case Reports ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Surgical Department ◽  
Helicobactor Pylori ◽  
Urgent Surgery ◽  
First Case ◽  
Chest X Ray

Helicobactor pylori infection has been associated with peptic ulcer disease and is currently treated with proton pump inhibitors (PPIs), which have reduced the complications of the disease. Perforation of either a gastric or duodenal ulcer is rarely treated with surgery. We report the case of double-perforated synchronous duodenal ulcers, which is an extremely infrequent condition. To our knowledge, no English case reports have yet been published. Therefore, awareness of the physician in the field of diagnosis and treatment of this peptic ulcer is required. We report the case of a 46-year-old male patient who presented with acute abdominal pain at the emergency surgical department of our hospital. According to patient history, smoking, alcohol consumption, and frequent postprandial abdominal pain were noted. A physical examination revealed a rigid abdomen and tachycardia, and the temperature was 37.8°C. Laboratory testing showed increased levels of leukocytes, and free subdiaphragmatic air was found in the chest X-ray. Due to rapid deterioration of his clinical condition, the patient underwent urgent surgery. An explorative laparotomy showed 2 perforated kissing ulcers at the first segment of the duodenum, in the anterior and posterior walls. A peripheral gastrectomy was performed. Postoperative follow-up did not result in any complications. In regard to this case we present, simultaneous perforation of two synchronous duodenal ulcers is an uncommon but possible incident of which the clinician should be aware. To our knowledge, this is the first case published in the literature.

scholarly journals Acute abdominal pain and nephrotic syndrome: pediatric case reports and review of the literature

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Giovanni Conti ◽  
Nicolina Stefania Carucci ◽  
Valentina Comito ◽  
Pietro Impellizzeri ◽  
Carmela Visalli ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Abdominal Pain ◽  
Acute Abdominal Pain ◽  
Case Reports ◽  
Team Approach ◽  
Pediatric Case ◽  
Correct Treatment ◽  
Spontaneous Reduction ◽  
Primary Peritonitis ◽  
First Case

Abstract Background Acute abdominal pain in nephrotic syndrome (NS) is a well-known clinical symptom and is mainly related to peritonitis. The presence, although rare, of red umbilicus may guide the diagnosis as a suggestive sign of peritonitis also in the non-neonatal period. Instead, the association between intussusception and NS is quite limited. We reviewed all published cases in the literature, and to our knowledge, this is one of the few pediatric cases of spontaneous resolution of intussusception in the setting of NS. Finally, a review of the causes of abdominal pain during the course of NS was made. Cases presentation We report two pediatric patient cases who complained of acute abdominal pain during a relapse episode of their NS. The first case is a 4-year-old boy with NS (fourth relapse) who presented with acute abdominal pain, ascites, and red umbilicus. Our suspect of primary peritonitis was clinically confirmed because of the subsequent appearance of the classical peritoneal signs. The second case is a 4-year-old boy who developed an ileo-ileal intussusception during the treatment of his first NS relapse, with spontaneous reduction. Conclusions Gastrointestinal disorders are frequently encountered in the course of NS. The appearance of acute abdominal pain in children with NS requires quick management, both clinical and instrumental. A multidisciplinary team approach needs to be encouraged to lead to an accurate diagnosis and a correct treatment.

Suicidal thoughts in patients with Parkinson’s disease treated by deep brain stimulation of the subthalamic nuclei: two case reports and review of the literature

2007 ◽  
Vol 19 (3) ◽  
pp. 208-210 ◽  
Author(s):  
Yacov Balash ◽  
Doron Merims ◽  
Nir Giladi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Case Reports ◽  
First Case ◽  
Life Threatening ◽  
Case Presentations ◽  
Depressive Episodes ◽  
Deep Brain

Background:Deep brain stimulation (DBS) of the subthalamic nuclei (STN) can result in depression despite the obvious motor improvement.Case presentations:Two patients with serious life-threatening depressive episodes are described. In the first case, the trigger for depression was a slight adjustment of the left stimulating electrode’s contact. In the second case, reducing both the dopaminergic therapy and the voltage of DBS resulted in the manifestation of depressive symptoms.Conclusions:DBS-induced depression possibly has pathogenetic differences from ordinary Parkinson’s disease depression. The STN region seems to be a sensitive zone that influences emotions.

First Case Report of F-18 FDG PET/CT in a Rare Case of Bilateral Adrenal and Lung Metastasis from Primary Hepatic Angiosarcoma

2018 ◽  
Vol 7 (1) ◽  
pp. 75-76
Author(s):  
Koramadai Karuppusamy Kamaleshwaran ◽  
Edathurthy Kalarikal Radhakrishnan ◽  
Raghi Paramben Jose ◽  
Ajit Sugunan Shinto
Keyword(s):  
Case Report ◽  
Lung Metastasis ◽  
Fdg Pet ◽  
Rare Case ◽  
Hepatic Angiosarcoma ◽  
First Case ◽  
Pet Ct ◽  
Primary Hepatic Angiosarcoma ◽  
Fdg Pet Ct

Metformin-Associated Exacerbation of Chronic Pancreatitis: A Possible Adverse Drug-Disease Interaction

2012 ◽  
Vol 28 (5) ◽  
pp. 208-210 ◽  
Author(s):  
Thomas G Wadsworth ◽  
Jo Kiester ◽  
E Gregory Thompson
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Case Reports ◽  
Severe Exacerbation ◽  
Metformin Therapy ◽  
First Case ◽  
Persistent Abdominal Pain ◽  
Elevated Glucose ◽  
The Right

Objective: To report a case of metformin-associated exacerbation of chronic pancreatitis and examine this possible drug-disease interaction. Case Summary: A 59-year-old woman with chronic pancreatitis (CP) experienced a severe exacerbation of her characteristic chronic abdominal pain 3 weeks after initiation and titration of metformin therapy; the exacerbation resolved upon discontinuation of metformin. The patient presented to the emergency department experiencing nausea and severe right upper quadrant abdominal pain with radiation to the right flank. Persistent abdominal pain, which had been a primary feature of CP, was previously mild and easily controlled with oral analgesics. Laboratory studies ruled out acute pancreatitis and were significant only for elevated glucose (168 mg/dL). Subsequently, she was given intravenous pain and nausea medications and discharged to home. The pain and nausea shortly returned and continued for 3 more days, at which point she telephoned her gastroenterologist, who advised that she discontinue metformin because of possible adverse reaction. Within a few days of discontinuing metformin, the nausea resolved and abdominal pain gradually returned to baseline level. Discussion: Metformin is not generally known to cause or exacerbate pancreatitis, although cases of acute pancreatitis associated with metformin therapy have been reported in the literature. No cases involving chronic pancreatitis have been reported. Consequently, metformin's prescribing guidelines do not contain precautions or contraindications for patients with chronic pancreatitis. Use of the Naranjo probability scale for assessment of this case revealed that the adverse drug effect was possible, reflecting the symptomatic resolution upon discontinuation while accounting for the lack of causative certainty, previous conclusive case reports, as well as the presence of possible nondrug causes. Conclusions: To our knowledge, this is the first case describing metformin-associated exacerbation of chronic pancreatitis. Although this occurrence may be rare, cautionary consideration, education, and monitoring should accompany initiation of metformin therapy in select patients with chronic pancreatitis.

scholarly journals Primary Peritonitis: An Index Case of Mycoplasma hominis Infection in a Healthy Female

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Sabrina Drexel ◽  
Daniel Tseng
Keyword(s):  
Abdominal Pain ◽  
Peritoneal Fluid ◽  
Case Reports ◽  
Uterine Fibroids ◽  
Healthy Woman ◽  
Systemic Infection ◽  
Mycoplasma Hominis ◽  
Unknown Etiology ◽  
Primary Peritonitis ◽  
First Case

Introduction. Primary peritonitis in healthy immunocompetent individuals is rare. Several case reports of Streptococcus species causing peritonitis have been described. Here, we present the first case of Mycoplasma hominis as the cause of primary peritonitis in a healthy woman. Case Report. A 42-year-old female with history of uterine fibroids was admitted with abdominal pain and intraperitoneal fluid of unknown etiology. She was initially managed nonoperatively and empirically treated with broad spectrum antibiotics. Blood and urine cultures were unrevealing. Increasing abdominal pain and peritoneal fluid prompted diagnostic laparoscopy which revealed a dense fibrinous exudate covering the entire peritoneal cavity. Peritoneal fluid and biopsies were sent for cytology and culture. The peritoneal fluid was eventually sent for 16 s ribosomal analysis, which discovered Mycoplasma hominis RNA. Her antibiotics were narrowed, and she eventually made a full recovery. Discussion. M. hominis is a rare source of systemic infection but has been known to colonize the urogenital tract and cause localized infections. This is the first presentation of M. hominis causing primary peritonitis in a healthy immunocompetent female. Multidisciplinary management of these patients is critical to achieve a timely diagnosis. Surgical exploration is often unavoidable to rule out secondary peritonitis.

scholarly journals Rhabdomyolysis Following Administration of Comirnaty®

2021 ◽  
Author(s):  
Catarina Elias ◽  
Pedro Cardoso ◽  
Diana Gonçalves ◽  
Inês Vaz ◽  
Leila Cardoso
Keyword(s):  
Temporal Relationship ◽  
Case Reports ◽  
Disease Onset ◽  
European Medicines Agency ◽  
Case Description ◽  
Electrolyte Disturbance ◽  
First Case ◽  
Common Causes ◽  
Favourable Evolution ◽  
Full Knowledge

Introduction: Vaccination against COVID-19 is essential to control the pandemic. The vaccines developed so far have good safety profiles but full knowledge of adverse effects will only be acquired with time and through case reports. Case Description: We present the case of a man admitted with rhabdomyolysis 3 days after receiving his first dose of the Pfizer coronavirus vaccine Comirnaty® Other traumatic, infectious, endocrine, electrolyte disturbance and autoimmune causes of rhabdomyolysis were excluded. The temporal relationship between vaccine administration and disease onset indicated possible causality. The patient had a favourable evolution after receiving fluids and completely recovered. To our knowledge, there have been only 69 reports of rhabdomyolysis following Comirnaty® administration in Europe, as stated by the European Medicines Agency, and this is the first case report in Portugal. Discussion: When a patient presents with rhabdomyolysis without an obvious traumatic or exertional cause, other aetiologies need to be excluded. Drug use is one of the most common causes of rhabdomyolysis in adults. Conclusion: We present a case compatible with an adverse effect of Comirnaty® in order to raise awareness of this condition in vaccinated patients.  

scholarly journals SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Albert Martin-Cardona ◽  
Josep Lloreta Trull ◽  
Raquel Albero-González ◽  
Marta Paraira Beser ◽  
Xavier Andújar ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Endothelial Cells ◽  
Abdominal Pain ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Ischaemic Colitis ◽  
Intestinal Tissue ◽  
First Case ◽  
Transmission Electron

Abstract Background SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is poorly known. Transmission electron microscopy (TEM) is a useful tool that provides an understanding of SARS-CoV-2 invasiveness, replication and dissemination in body cells but information outside the respiratory tract is very limited. We report two cases of severe intestinal complications (intestinal lymphoma and ischaemic colitis) in which the presence of SARS-CoV-2 in intestinal tissue was confirmed by TEM. These are the first two cases reported in the literature of persistence of SARS-CoV-2 demonstrated by TEM in intestinal tissue after COVID 19 recovery and SARS-CoV-2 nasopharyngeal clearance. Case presentation During the first pandemic peak (1st March–30th April 2020) 932 patients were admitted in Hospital Universitari Mútua Terrassa due to COVID-19, 41 (4.4%) required cross-sectional imaging techniques to assess severe abdominal pain and six of them (0.64%) required surgical resection. SARS-CoV-2 in bowel tissue was demonstrated by TEM in two of these patients. The first case presented as an ileocaecal inflammatory mass which turned to be a B-cell lymphoma. Viral particles were found in the cytoplasm of endothelial cells of damaged mucosa. In situ hybridization was negative in tumour cells, thus ruling out an oncogenic role for the virus. SARS-CoV-2 remained in intestinal tissue 6 months after nasopharyngeal clearance, suggesting latent infection. The second patient had a severe ischaemic colitis with perforation and SARS-CoV-2 was also identified in endothelial cells. Conclusions Severe intestinal complications associated with COVID-19 are uncommon. SARS-CoV-2 was identified by TEM in two cases, suggesting a causal role in bowel damage.

Association between the frequency of daily tooth brushing and development of nonalcoholic fatty liver disease

2021 ◽  
Author(s):  
Kazuki Yamamoto ◽  
Takashi Ikeya ◽  
Shuhei Okuyama ◽  
Katsuyuki Fukuda ◽  
Daiki Kobayashi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Primary Outcome ◽  
Tooth Brushing ◽  
Health Checkup ◽  
Abdominal Ultrasonography ◽  
Nonalcoholic Fatty Liver ◽  
The Mean

Background & Aims: This study aimed to evaluate the association between the frequency of daily tooth brushing and the development of nonalcoholic fatty liver disease (NAFLD). Methods: A retrospective longitudinal study was conducted from 2005 to 2012 at the Center for Preventive Medicine at St. Luke's International Hospital, Japan. Data on all participants who underwent a health checkup during the study period were collected. NAFLD was diagnosed by abdominal ultrasonography, and all participants who were diagnosed with NALFD at the time of their initial visit, consumed alcohol in any amount, or had received only one health checkup were excluded. The questionnaire for the frequency of daily tooth brushing was conducted as part of health checkups. The primary outcome was the risk of developing NAFLD according to the frequency of daily tooth brushing (1-2 times a day, or 3 times a day) compared to those who brush teeth once or less than once a day. Results: Data were collected from 25,804 people. A total of 3,289 (12.7%) participants developed NAFLD. The mean age was 45.2 years, and 6,901 (26.7%) of the participants were male. The risk of developing NAFLD significantly decreased with increased frequency of daily tooth brushing. Adjusted odds ratios (ORs) are as follows: Brushing teeth 1-2 times a day (OR: 0.85, 95% CI: 0.77-0.95), and 3 times a day (OR: 0.74, 95% CI: 0.67-0.82). Conclusions: Frequent tooth brushing was shown to significantly reduce the risk of developing NAFLD.　

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