Short-Term Vitamin D3 Supplementation in Children with Neurodisabilities: Comparison of Two Delivery Methods

2017 ◽  
Vol 88 (3-4) ◽  
pp. 281-284 ◽  
Author(s):  
Francesca Penagini ◽  
Barbara  Borsani ◽  
Katia Maruca ◽  
Valeria Giosia ◽  
Stefania Bova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Tube Feeding ◽  
Term Treatment ◽  
Short Term ◽  
Delivery Methods ◽  
Short Term Treatment ◽  
Vitamin D3 Supplementation ◽  
D 20

Background/Aims: Vitamin D deficiency is common in children with neurodisabilities. Oral vitamin D3 may not be absorbed appropriately due to dysphagia and tube feeding. The aim of this study was to compare efficacy of vitamin D3 buccal spray with that of oral drops. Methods: Twenty-four children with neurodisabilities (5–17 years) and vitamin D deficiency (25(OH)D ≤20 ng/mL) were randomized to receive vitamin D3 buccal spray 800 IU/daily (n = 12) or oral drops 750 IU/daily (n = 12) for 3 months during winter. Results: Both groups had a significant increase in 25(OH)D (z = 150; p < 0.0001). The differences between baseline and final parathyroid hormone measurements did not reach significance in both groups. Markers of bone formation and resorption did not change significantly in both groups. The satisfaction with the formulation was significantly higher in the patients using spray. Conclusion: Vitamin D3 supplementation with buccal spray and oral drops are equally effective in short-term treatment of vitamin D deficiency in children with neurodisabilities. Buccal spray may be more acceptable by the patients.

scholarly journals Role of Vitamin D3 in fracture union in adults

2021 ◽  
Vol 7 (1) ◽  
pp. 38-41
Author(s):  
Arunabh Arora ◽  
Amrit Kumar Singh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Healing ◽  
Vitamin D3 ◽  
Serum Alkaline Phosphatase ◽  
Serum Vitamin ◽  
The Elderly ◽  
Fracture Union ◽  
Advantages And Disadvantages ◽  
Vitamin D3 Supplementation

Fractures play an important role in morbidity and often premature mobility among the elderly population. Because inactivity as a result of a fracture is harmful both to bone healing and health, it appears early or rapid fracture healing would be highly recommendable for returning fracture patients to come back to normal as soon as possible with minimal side effects. The literature remains unclear regarding supplementation required for promoting bone healing in fracture cases. Hereby we evaluated the advantages and disadvantages of vitamin D3 supplementation in fracture cases along with the quantitative analysis of vitamin D3 at the time of fracture and after fracture union.: A total of 200 patients were assessed clinically, biochemically (serum alkaline phosphatase, serum vitamin D3, and serum parathormone), and radiologically. All patients who satisfy inclusion criteria are followed up and vitamin D3 levels were measured up within 1 day of fracture and at the interval of 6 months after the orthopaedic intervention. The outcomes were monitored by the 5 points radiographic scoring system by Warden et al. With the majority of patients falling under the vitamin insufficiency group i.e. 53% of all patients were found to be vitamin insufficient at the time of fracture. 33% of patients found to be vitamin D deficient while 14% found to be insufficient stage. No patient was found to be in a toxicity state. According to Warden’s scoring., 50% of patients were in grade 3, 15% in grade 4, 33% in grade 2, and only 2% in grade 1. Regarding the prevalence of vitamin D deficiency or insufficiency in the general population, this study shows an alarming rate of vitamin D insufficient patients in a group of 200 patients, which indicates the need for attention towards vitamin D status not only for bone-related issues but for other issues related to vitamin D deficiency.

scholarly journals Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation

2016 ◽  
Vol 102 (1) ◽  
pp. 100-110 ◽  
Author(s):  
Pang Yao ◽  
Liang Sun ◽  
Ling Lu ◽  
Hong Ding ◽  
Xiafei Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Inverse Association ◽  
Vitamin D Metabolism ◽  
Hydroxyvitamin D ◽  
Vitamin D3 Supplementation ◽  
Double Blinded

Abstract Context: Little is known about how genetic and nongenetic factors modify responses of vitamin D supplementation in nonwhite populations. Objective: To investigate factors modifying 25-hydroxyvitamin D [25(OH)D] and bioavailable 25(OH)D [25(OH)DBio] responses after vitamin D3 supplementation. Design, Setting, Participants, and Intervention: In this 20-week, randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency received 2000 IU/d vitamin D3 or placebo. Main Outcome Measures: Serum 25(OH)D, vitamin D-binding protein (VDBP), parathyroid hormone (PTH) and calcium were measured, and 25(OH)DBio was calculated based on VDBP levels. Six common polymorphisms in vitamin D metabolism genes were genotyped. Results: Between-arm net changes were +30.6 ± 1.7 nmol/L for 25(OH)D, +2.7 ± 0.2 nmol/L for 25(OH)DBio, and −5.2 ± 1.2 pg/mL for PTH, corresponding to 70% [95% confidence interval (CI), 62.8% to 77.2%] net reversion rate for vitamin D deficiency at week 20 (P &lt; 0.001). Only 25(OH)DBio change was positively associated with calcium change (P &lt; 0.001). Genetic factors (GC-rs4588/GC-rs7041, VDR-rs2228570, and CYP2R1-rs10741657; P ≤ 0.04) showed stronger influences on 25(OH)D or 25(OH)DBio responses than nongenetic factors, including baseline value, body mass index, and sex. An inverse association of PTH-25(OH)D was demonstrated only at 25(OH)D of &lt;50.8 (95% CI, 43.6 to 59.0) nmol/L. Conclusions: Supplemented 2000 IU/d vitamin D3 raised 25(OH)D and 25(OH)DBio but was unable to correct deficiency in 25% of Chinese participants, which might be partially attributed to the effect of genetic modification. More studies are needed to elucidate appropriate vitamin D recommendations for Asians and the potential clinical implications of 25(OH)DBio.

scholarly journals Serum Bone Gla-protein Increases Following Short-term Oral Administration of Active Vitamin D3 in the Elderly with Vitamin D Deficiency.

1997 ◽  
Vol 34 (9) ◽  
pp. 733-738
Author(s):  
Kiyoshi Nakatsuka ◽  
Hidetoshi Kosaka ◽  
Kiichiro Sekiya ◽  
Shoshi Takamoto ◽  
Toshio Onishi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Oral Administration ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
The Elderly ◽  
Bone Gla Protein ◽  
Active Vitamin ◽  
Short Term

Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 – A Randomized Clinical Trial

2020 ◽  
Vol 27 (5) ◽  
pp. 302-309 ◽  
Author(s):  
Masoumeh Khalighi Sikaroudi ◽  
Marjan Mokhtare ◽  
Leila Janani ◽  
Amir Hossein Faghihi Kashani ◽  
Mohsen Masoodi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Irritable Bowel Syndrome ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Interleukin 6 ◽  
Intervention Group ◽  
Control Group ◽  
Vitamin D3 Supplementation ◽  
Irritable Bowel

Objectives: This study aimed to evaluate whether vitamin D deficiency is associated with the severity of symptoms of irritable bowel syndrome (IBS) patients. Stress and gut inflammation can increase the serum level of corticotropin-releasing hormone (CRH) and interleukin-6 (IL-6), leading to a change in bowel movements. The aim of this study was to evaluate the anti-inflammatory and psychological effects of vitamin D3 supplementation on the symptom improvement of patients with a diarrhea-predominant form of IBS (IBS-D). Methods: Eighty-eight IBS-D patients (age: 18–65 years) based on Rome IV criteria who suffered from vitamin D deficiency and/or insufficiency were enrolled in this randomized, placebo-controlled trial from February 2017 to May 2018 at Rasoul-e-Akram Hospital, Tehran, Iran. Participants were randomly divided into two groups. The intervention group received 50,000 IU vitamin D3 weekly and the control group received a placebo for 9 weeks. All patients received Mebeverine 135 mg twice a day besides supplementation. The IBS Severity Score System (IBS-SSS), serum 25(OH) vitamin D3, CRH, and IL-6 were measured before and after interventions. Results: Seventy-four patients completed the study. The severity of IBS symptoms (p < 0.01) and IL-6 (p = 0.02) decreased significantly in the intervention group as compared to the control group, but there was no significant difference in the serum level of CRH. Also, in the treatment group, IBS-SSS and IL-6 were significantly reduced at the end of the study from baseline (p < 0.01 and p < 0.03, respectively). Conclusion: Our findings indicate that vitamin D3 supplementation can modulate the serum level of CRH and IL-6 and can improve symptoms in IBS-D patients. Vitamin D3 supplementation should be considered in IBS-D patients who suffer from vitamin D deficiency and/or insufficiency.

scholarly journals Effect of Vitamin D3 Supplement on Biochemical Markers and Blood Pressure Reading in Hypertensive patients as A secondary Prevention

2018 ◽  
pp. 24-32
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Controlled Study ◽  
Age Group ◽  
Hypertensive Patients ◽  
Vitamin D3 Supplementation ◽  
Duration Of Disease ◽  
To Receive

Hypertension is the most significant risk factors for cardiovascular morbidity and mortality. It has two classes according to causes of the high blood pressure (Primary and Secondary). This study was intended to evaluate the potential benefit of vitamin D3 supplementation as a secondary preventive therapy for hypertensive patients. It is a prospective randomized controlled study was carried out on 40 patients visiting the Imam Al-Hussein medical city / Karbala and conducted from Sep 2016 to May 2017. The patients were allocated into group1; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive conventional therapy for hypertension with vitamin D3 (100000 IU) orally every 2 weeks for 8 weeks, and group 2; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive anti hypertension therapy only. Ethical committee approval and written consent of patients were obtained. Results revealed that the effect of vitamin D3 supplementation on both angiotensin II level and endogenous vitamin D levels were significantly clear regardless of age group, gender, BMI, duration of disease, and smoking status, except for systolic and diastolic blood pressure, TC, and LDL-c was affected particularly by age group and the duration of disease.

scholarly journals Cost-effectiveness of vitamin D3 supplementation in older adults with vitamin D deficiency in Ireland

2021 ◽  
Author(s):  
Laurence Francis Lacey ◽  
David Armstrong ◽  
Emily Royle ◽  
Pamela J Magee ◽  
Kirsty Pourshahidi ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cost Effectiveness ◽  
Vitamin D Deficiency ◽  
Hip Fractures ◽  
Vitamin D3 ◽  
Age Groups ◽  
Life Years ◽  
Vitamin D3 Supplementation ◽  
The Cost

Background: This study investigated the cost-effectiveness of vitamin D3 supplementation in older adults in Ireland, with year-round vitamin D deficiency (serum 25-hydroxyvitamin D concentration <30 nmol/L) (13% of Irish adults), from the perspective of the Health Service Executive (HSE). Methods: Three age groups were investigated: (1) >=50 years, (2) >=60 years, (3) >=70 years. Based on the clinical literature, vitamin D3 supplementation may (1) decrease all-cause mortality by 7%, and (2) reduce hip fractures by 16%, and non-hip fractures by 20%. A discount rate of 4% was applied to life years and QALYs gained. The annual healthcare costs per patient used in the model are based on the average annual health resource use over the 5-year time horizon of the model. Results: The cost/QALY estimates in all three age groups are below the usually acceptable cost-effectiveness threshold of Euro20,000/QALY. The most cost-effective and least costly intervention was in adults >=70 years. For this age group, the average annual costs and outcomes would be approx. Euro6.2 million, 1,043 QALYs gained, with a cost/QALY of approx. Euro6,000. The results are most sensitive to the mortality risk reduction following vitamin D3 supplementation. Conclusion: The cost-effectiveness of vitamin D3 supplementation is most robust in adults >=70 years. Clinical uncertainty in the magnitude of the benefits of vitamin D3 supplementation could be further addressed by means of (1) performing a clinical research study or (2) conducting a pilot/regional study, prior to reaching a decision to invest in a full nationwide programme.

Sign in / Sign up

Export Citation Format

Share Document