Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study

2017 ◽  
Vol 54 (5) ◽  
pp. 309-319 ◽  
Author(s):  
Kristoffer Flintholm Raft ◽  
Daria Frestad ◽  
Marie Mide Michelsen ◽  
Hannah Elena Suhrs ◽  
Anna Bay Rask ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Flow Velocity ◽  
Coronary Flow ◽  
Obstructive Coronary Artery Disease ◽  
Coronary Flow Velocity Reserve ◽  
Coronary Flow Velocity ◽  
Artery Disease

scholarly journals Transthoracic Assessment of Coronary Flow Velocity Reserve: A Practical Approach to Diagnostic Testing in Patients with Angina and No Obstructive Coronary Artery Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Daria Frestad Bechsgaard ◽  
Eva Prescott
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Flow Velocity ◽  
Coronary Flow ◽  
Obstructive Coronary Artery Disease ◽  
Coronary Microvascular Dysfunction ◽  
Coronary Flow Velocity Reserve ◽  
Transthoracic Doppler Echocardiography ◽  
Coronary Flow Velocity ◽  
Artery Disease

More than half of the patients with symptoms suggestive of myocardial ischemia presenting at invasive angiography have no obstructive coronary artery disease (CAD). A large proportion of these patients have ischemia caused by coronary microvascular dysfunction, a condition associated with adverse cardiovascular prognosis. Measurement of coronary flow velocity reserve by transthoracic Doppler echocardiography is a feasible and reproducible method for the evaluation of coronary microvascular function. This review provides a practical overview of the method in a clinical setting of angina and noobstructive CAD, including technical details and prognostic significance.

scholarly journals Coronary flow velocity reserve predicts adverse prognosis in women with angina and no obstructive coronary artery disease: results from the iPOWER study

2020 ◽  
Author(s):  
Jakob Schroder ◽  
Marie M Michelsen ◽  
Naja D Mygind ◽  
Hannah E Suhrs ◽  
Kira B Bove ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Flow ◽  
Adverse Outcome ◽  
Obstructive Coronary Artery Disease ◽  
Composite Outcome ◽  
Coronary Flow Velocity Reserve ◽  
Coronary Flow Velocity ◽  
Artery Disease

Abstract Aims  Many patients with angina, especially women, do not have obstructive coronary artery disease (CAD) yet have impaired prognosis. We investigated whether routine assessment of coronary microvascular dysfunction (CMD) is feasible and predicts adverse outcome in women with angina and no obstructive CAD. Methods and results  After screening 7253, we included 1853 women with angina and no obstructive CAD on angiogram who were free of previous CAD, heart failure, or valvular heart disease in the prospective iPOWER (Improving Diagnosis and Treatment of Women with Angina Pectoris and Microvascular Disease) study. CMD was assessed by Doppler echocardiography in the left anterior descending artery as coronary flow velocity reserve (CFVR). Patients were followed for a composite outcome of cardiovascular death, myocardial infarction (MI), heart failure, stroke, and coronary revascularization. CFVR was obtained in 1681 patients (91%) and the median CFVR was 2.33 (quartiles 1–3: 2.00–2.74). During a median follow-up of 4.5 years, 96 events occurred. In univariate Cox regression, CFVR was associated with the composite outcome {hazard ratio (HR) 1.07 [95% confidence interval (CI) 1.03–1.11] per 0.1 unit decrease in CFVR; P < 0.001}, primarily driven by an increased risk of MI and heart failure. Results remained significant in multivariate analysis [HR 1.05 (95% CI 1.01–1.09) per 0.1 unit decrease in CFVR; P = 0.01]. In exploratory analyses, CFVR was also associated with the risk of repeated hospital admission for angina and all-cause mortality. Conclusion  Assessment of CFVR by echocardiography is feasible and predictive of adverse outcome in women with angina and no obstructive CAD. Results support a more aggressive preventive management of these patients and underline the need for trials targeting CMD.

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