Role of Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Pediatric Brain Tumors on 3T

2017 ◽  
Vol 52 (5) ◽  
pp. 298-305 ◽  
Author(s):  
Pradeep Kumar Gupta ◽  
Jitender Saini ◽  
Prativa Sahoo ◽  
Rana Patir ◽  
Sunita Ahlawat ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Perfusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Pediatric Brain

The role of diffusion-weighted magnetic resonance imaging in pediatric brain tumors

2006 ◽  
Vol 22 (11) ◽  
pp. 1435-1439 ◽  
Author(s):  
Peter Kan ◽  
James K. Liu ◽  
Gary Hedlund ◽  
Douglas L. Brockmeyer ◽  
Marion L. Walker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
Pediatric Brain

Perfusion magnetic resonance imaging in pediatric brain tumors

2017 ◽  
Vol 59 (11) ◽  
pp. 1143-1153 ◽  
Author(s):  
F. Dallery ◽  
R. Bouzerar ◽  
D. Michel ◽  
C. Attencourt ◽  
V. Promelle ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Perfusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Pediatric Brain

Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors

Cancer ◽  
2004 ◽  
Vol 100 (6) ◽  
pp. 1246-1256 ◽  
Author(s):  
A. Aria Tzika ◽  
Loukas G. Astrakas ◽  
Maria K. Zarifi ◽  
David Zurakowski ◽  
Tina Young Poussaint ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Perfusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Pediatric Brain

Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced-Magnetic Resonance Imaging

2018 ◽  
Vol 140 (5) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Magnetic Resonance Imaging ◽  
Experimental Data ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Human Brain ◽  
Therapeutic Efficacy ◽  
Free Drug ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Systemic administration of drugs in tumors is a challenging task due to unorganized microvasculature and nonuniform extravasation. There is an imperative need to understand the transport behavior of drugs when administered intravenously. In this study, a transport model is developed to understand the therapeutic efficacy of a free drug and liposome-encapsulated drugs (LED), in heterogeneous vasculature of human brain tumors. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data is employed to model the heterogeneity in tumor vasculature that is directly mapped onto the computational fluid dynamics (CFD) model. Results indicate that heterogeneous vasculature leads to preferential accumulation of drugs at the tumor position. Higher drug accumulation was found at location of higher interstitial volume, thereby facilitating more tumor cell killing at those areas. Liposome-released drug (LRD) remains inside the tumor for longer time as compared to free drug, which together with higher concentration enhances therapeutic efficacy. The interstitial as well as intracellular concentration of LRD is found to be 2–20 fold higher as compared to free drug, which are in line with experimental data reported in literature. Close agreement between the predicted and experimental data demonstrates the potential of the developed model in modeling the transport of LED and free drugs in heterogeneous vasculature of human tumors.

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