scholarly journals A Modified Classification of Prognostic Factors Based on Pathological Stage and Tumor Regression Grade in Patients with Rectal Cancer Who Receive Preoperative Chemoradiotherapy

Oncology ◽  
2017 ◽  
Vol 93 (5) ◽  
pp. 287-294 ◽  
Author(s):  
Toshiyuki Suzuki ◽  
Sotaro Sadahiro ◽  
Akira Tanaka ◽  
Kazutake Okada ◽  
Gota Saito ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Factors ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Pathological Stage ◽  
Regression Grade

scholarly journals EP-1479: Impact of tumor regression grade in ypStage III rectal cancer after preoperative chemoradiotherapy

2018 ◽  
Vol 127 ◽  
pp. S801-S802
Author(s):  
J.H. Chung ◽  
C.H. Song ◽  
S.B. Kang ◽  
D.W. Kim ◽  
J.H. Kim ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Regression Grade

scholarly journals Clinical Significance of Tumor Regression Grade in Rectal Cancer with Preoperative Chemoradiotherapy

2010 ◽  
Vol 26 (4) ◽  
pp. 279 ◽  
Author(s):  
Young Joo Park ◽  
Byung Ryul Oh ◽  
Sang Woo Lim ◽  
Jung Wook Huh ◽  
Jae Kyun Joo ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Clinical Significance ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Regression Grade

Tumor regression grade as a clinically useful outcome predictor in patients with rectal cancer after preoperative chemoradiotherapy

Surgery ◽  
2019 ◽  
Vol 165 (3) ◽  
pp. 579-585 ◽  
Author(s):  
Jung Wook Huh ◽  
Hee Cheol Kim ◽  
Seok Hyung Kim ◽  
Yoon Ah Park ◽  
Yong Beom Cho ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Outcome Predictor ◽  
Regression Grade

Evaluation of the pathologic features of positive lymph nodes in the mesorectum after short-term preoperative chemoradiotherapy.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 571-571
Author(s):  
Naohito Beppu ◽  
Hidenori Yanagi ◽  
Hiroshi Doi ◽  
Norihiko Kamikonya ◽  
Yasuhiro Inoue ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Tumor Regression ◽  
Preoperative Chemoradiotherapy ◽  
Tumor Regression Grade ◽  
Pathologic Features ◽  
The Relationship ◽  
Regression Grade ◽  
Positive Lymph Nodes

571 Background: The purpose of this study was to investigate the relationship between the pathological degeneration of primary tumor and positive lymph nodes (LNs) after preoperative chemoradiotherapy for rectal cancer. Methods: We analyzed the resected specimens from 53 patients (pts) with ypN+ rectal cancer received curative resection after chemoradiotherapy (25 Gy/10 fr/5 days+S-1 80 mg/m2×10 days).The primary tumor regression was assessed using the tumor regression grade (TRG 0 to 4) according to Dworak classification. 144 positive LNs in the mesorectum were measured and were assessed using the LN regression grade (LRG) as follows; LRG 1 =minor to moderate regression, LRG 2 =major regression, and LRG 3 =total regression. To confirm apoptosis, the LNs with LRG 2 or 3 were stained by TUNEL method. Furthermore, we examined the relationship among the size of LNs, the TRG, and the LRG. Results: The TRG 1, 2, and 3 was found in 24 pts, 15 pts, and 14 pts, respectively. In addition, there were no pts with TRG 0 or 4. The LRG 1, 2, and 3 was found in 74 LNs, 48 LNs, and 22 LNs, respectively. 14 in 15 LNs equal to or greater than 10 mm (≥10mm) showed the LRG 1.Whereas, in 129 LNs less than 10 mm (<10mm), the proportion of the LRG 2 or 3 in pts with each TRG was 33.8 % (26/77), 69.0 % (20/29), and 100 % (23/23) in the TRG 1, 2, and 3 respectively. Conclusions: 1) Larger LNs (≥10 mm) seemed to be radioresistant. 2) A good correlation of the response to chemoradiation between the primary tumor and LNs were observed in smaller LNs (< 10 mm). 3) Primary tumor with the TRG 3 can predict the efficacy of preoperative chemoradiotherapy for the positive LNs in the pts with rectal cancer.

Rectal cancer – current treatment strategy and the tumor regression grade evaluation after neoadjuvant therapy in patients who underwent surgery at the I. Department of Surgery, General University Hospital in Prague between 2012 and 2016

2021 ◽  
Vol 100 (2) ◽  
Keyword(s):  
Rectal Cancer ◽  
Neoadjuvant Therapy ◽  
Tumor Regression ◽  
Neoadjuvant Treatment ◽  
Neoadjuvant Chemoradiotherapy ◽  
Current Treatment ◽  
University Hospital ◽  
Tumor Regression Grade ◽  
Oncological Treatment ◽  
Regression Grade

Introduction: The article contains a summary of the issues of staging and therapy with an emphasis on the neoadjuvant treatment and associated tumor regression grade with the analysis of our own group of patients. Methods: Retrospective analysis of patients with rectal cancer who underwent a surgery at the 1st Department of Surgery – Thoratic, Abdominal and Injury Surgery; First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic, focusing on those who underwent neoadjuvant chemoradiotherapy and their pathologists evaluated tumor regression grade after the resection. Results: The group consists of 161 patients operated on between 2012 and 2016. 47 patients underwent neoadjuvant oncological treatment with further evaluation of the tumor regression grade by a pathologist, a scoring system according to Ryan was used. A complete pathological response was elicited in 10.4% of patients, no response in 35.4% of patients, and partial tumor regression in 54.2%. Conclusion: Although there is a difference in our results compared to foreign publications, the proportion of patients remains comparable. Studies evaluating the advantages versus disadvantages of neoadjuvant therapy will certainly follow, and the question of the suitability of surgical treatment as the only curative solution is partially raised.

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