Towards a Truly Developmental Epigenetics

2017 ◽  
Vol 60 (2-3) ◽  
pp. 124-138 ◽  
Author(s):  
Robert Lickliter ◽  
David C. Witherington
Keyword(s):  
Developmental Epigenetics

scholarly journals Epigenetical mechanisms of susceptibility to complex human diseases

2010 ◽  
Vol 8 (4) ◽  
pp. 44-56 ◽  
Author(s):  
Eugene L Patkin ◽  
John Quinn
Keyword(s):  
Crucial Role ◽  
Specific Role ◽  
Human Diseases ◽  
Dna Repeats ◽  
Developmental Epigenetics

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

scholarly journals Can Children Catch up from the Consequences of Undernourishment? Evidence from Child Linear Growth, Developmental Epigenetics, and Brain and Neurocognitive Development

2020 ◽  
Vol 11 (4) ◽  
pp. 1032-1041 ◽  
Author(s):  
Jef L Leroy ◽  
Edward A Frongillo ◽  
Pragya Dewan ◽  
Maureen M Black ◽  
Robert A Waterland
Keyword(s):  
Linear Growth ◽  
Maternal Nutrition ◽  
Normal Velocity ◽  
Neurocognitive Development ◽  
Child Undernutrition ◽  
Irreversible Effects ◽  
Absolute Height ◽  
Catch Up ◽  
Developmental Epigenetics

ABSTRACT Recovery from nutritionally induced height deficits continues to garner attention. The current literature on catch-up growth, however, has 2 important limitations: wide-ranging definitions of catch-up growth are used, and it remains unclear whether children can recover from the broader consequences of undernutrition. We addressed these shortcomings by reviewing the literature on the criteria for catch-up in linear growth and on the potential to recover from undernutrition early in life in 3 domains: linear growth, developmental epigenetics, and child brain and neurocognitive development. Four criteria must be met to demonstrate catch-up growth in height: after a period in which a growth-inhibiting condition (criterion 1) causes a reduction in linear growth velocity (criterion 2), alleviation of the inhibiting condition (criterion 3) leads to higher-than-normal velocity (criterion 4). Accordingly, studies that are observational, do not use absolute height, or have no alleviation of an inhibiting condition cannot be used to establish catch-up growth. Adoption and foster care, which provide dramatic improvements in children's living conditions not typically attained in nutrition interventions, led to some (but incomplete) recovery in linear growth and brain and neurocognitive development. Maternal nutrition around the time of conception was shown to have long-term (potentially permanent) effects on DNA methylation in the offspring. Undernourishment early in life may thus have profound irreversible effects. Scientific, program, and policy efforts should focus on preventing maternal and child undernutrition rather than on correcting its consequences or attempting to prove they can be corrected.

scholarly journals EpiDenovo: a platform for linking regulatory de novo mutations to developmental epigenetics and diseases

2017 ◽  
Vol 46 (D1) ◽  
pp. D92-D99 ◽  
Author(s):  
Fengbiao Mao ◽  
Qi Liu ◽  
Xiaolu Zhao ◽  
Haonan Yang ◽  
Sen Guo ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Mutations ◽  
Developmental Epigenetics
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